Physical Therapy Program and Treatment Expectations in Knee Osteoarthritis
8 juni 2026 uppdaterad av: Levent Karataş, Gazi University
Evaluating The Predictive Effect of Treatment Expectations on Response to A Physical Therapy Program in Patients With Knee Osteoarthritis
To our knowledge, no studies have been conducted in the literature investigating the relationship between the success of physical therapy programs applied in knee osteoarthritis and patients' pre-treatment expectations.
The rationale for this study is to demonstrate the possible relationship between treatment expectations and the benefits seen from conventional physical therapy programs in patients with knee osteoarthritis, and to provide clinicians with a different perspective in knee osteoarthritis treatment planning.
Studieöversikt
Status
Rekrytering
Betingelser
Intervention / Behandling
Detaljerad beskrivning
Osteoarthritis, also called degenerative joint disease, primarily occurs in old age, but can also develop after trauma or secondarily to diseases such as rheumatoid arthritis and hemochromatosis.
Osteoarthritis is the most common joint disease worldwide.
The pathophysiology of osteoarthritis is responsible for the failed repair of joint damage caused by stress initiated by any joint or periarticular tissue abnormality.
The most common symptom of osteoarthritis is pain.
Factors associated with an increased risk of knee osteoarthritis include advanced age, family history, overweight or obesity, a history of knee trauma, occupational factors, and varus or valgus alignment.
Long-term complications of osteoarthritis include decreased physical activity, loss of fitness, sleep disturbances, fatigue, and depression.
With the increasing aging population, degenerative joint problems have become a concern for a large part of society.
Exercise is a key component in the treatment of this chronic disease, which restricts functionality and reduces quality of life.
A systematic review of 54 randomized controlled trials involving a total of 5362 participants showed that different types of exercise improved pain, functionality, and quality of life in knee osteoarthritis.
Studies have shown that treatment outcomes are not always similar in patients undergoing similar treatment programs, and that patients' expectations from treatment can also influence results.
A systematic literature review on improvement expectations revealed that in 15 out of 16 studies, positive patient expectations were associated with better health outcomes.
A recent study in the field of physical therapy also showed that in the treatment of chronic low back pain, high patient expectations were associated with the success of the treatment.
Therefore, we planned this study to answer the questions of whether treatment expectations have a predictive effect on the benefits seen from an exercise program in patients with knee osteoarthritis, and whether it is necessary to evaluate the level of expectations when creating a treatment program for patients with knee osteoarthritis.
Studietyp
Observationell
Inskrivning (Beräknad)
84
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studiekontakt
- Namn: Burak Tokac
- Telefonnummer: +905313474837
- E-post: buraktokac96@gmail.com
Studera Kontakt Backup
- Namn: Levent Karatas
- Telefonnummer: +9005055629437
Studieorter
-
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Yenimahalle
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Ankara, Yenimahalle, Turkiet (Türkiye), 06170
- Rekrytering
- Gazi University
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Kontakt:
- Levent Karatas, Doc
- Telefonnummer: +90 505 562 94 37
- E-post: dr.levent.karatas@gmail.com
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-
Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
- Vuxen
- Äldre vuxen
Tar emot friska volontärer
Nej
Testmetod
Sannolikhetsprov
Studera befolkning
Patients aged 50 years and older who present with knee pain and are found to have grade 2 or higher gonarthrosis according to the Kellgren-Lawrence classification on X-ray imaging.
Beskrivning
Inclusion Criteria:
- Agreeing to participate in the study
- Being over 50 years of age
- Having a clinically and radiographically confirmed diagnosis of knee osteoarthritis
- Having grade 2-3-4 knee osteoarthritis according to the Kellgren-Lawrence grading system
- Being literate
Exclusion Criteria:
- Previous knee surgery
- Conditions that prevent exercise (such as incurable malignancy, active systemic infection, non-union fracture)
- Presence of accompanying neurological disease affecting the lower extremity
- Severe cognitive impairment (neuropsychiatric disease or condition that will impede cooperation, such as psychosis, dementia)
- History of having received injections or other procedures to the knee joint or physical therapy within the last 6 months
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
Kohorter och interventioner
Grupp / Kohort |
Intervention / Behandling |
|---|---|
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Those with Low Treatment Expectations
Using the Turkish version of the Treatment Expectation Questionnaire (TEX-Q)(English version is provided in the documents section), patients will be divided into two groups: those with low expectations and those with high expectations.
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Patients in both groups will receive 15 sessions of a conventional physical therapy program.
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Those with High Treatment Expectations
Using the Turkish version of the Treatment Expectation Questionnaire (TEX-Q)(English version is provided in the documents section), patients will be divided into two groups: those with low expectations and those with high expectations.
|
Patients in both groups will receive 15 sessions of a conventional physical therapy program.
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
The Western Ontario and McMaster Universities Arthritis Index (WOMAC) score
Tidsram: From enrollment day to the end of the rehabilitation program at 4 weeks
|
WOMAC score evaluation following the last treatment session.
The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is a widely used, validated questionnaire designed to assess pain, stiffness, and physical function in patients with knee and hip osteoarthritis.
It consists of 24 items divided into three subscales: pain (5 items), stiffness (2 items), and physical function (17 items).
Patients rate their symptoms on a Likert scale, with higher scores indicating worse pain, stiffness, or functional limitations.
The WOMAC is commonly used in clinical research to evaluate the efficacy of various treatments for osteoarthritis.
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From enrollment day to the end of the rehabilitation program at 4 weeks
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Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Smärtnivå; VAS-poäng
Tidsram: Från inskrivningsdag till slutet av rehabiliteringsprogrammet vid 4 veckor
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Visual Analog Scale (VAS) är ett verktyg som används för att mäta en patients smärtnivå.
Den består av en rak linje med ändpunkter som definierar extrema gränser som "ingen smärta" och "värsta smärta man kan tänka sig."
Patienten markerar på linjen den punkt som de känner representerar deras uppfattning om deras nuvarande tillstånd.
Denna metod är enkel, tillförlitlig och används ofta i både kliniska och forskningsmiljöer för att kvantifiera smärtintensiteten.
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Från inskrivningsdag till slutet av rehabiliteringsprogrammet vid 4 veckor
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Timed Up and Go Test (TUG)
Tidsram: From enrollment day to the end of the rehabilitation program at 4 weeks
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A rapid, standardized clinical tool used to measure a person's functional mobility, dynamic balance, and fall risk.
It measures the time it takes for a person to get up from a chair, walk 3 meters (10 feet), turn around, walk back, and sit down again.
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From enrollment day to the end of the rehabilitation program at 4 weeks
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Stair Climbing Test (SCT)
Tidsram: From enrollment day to the end of the rehabilitation program at 4 weeks
|
The stair climbing test assesses lower body strength, functional capacity, and cardiopulmonary fitness by measuring how quickly you can safely climb and descend a flight of stairs.
Versions are available with 3 to 12 steps; this study will use the 12-step version.
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From enrollment day to the end of the rehabilitation program at 4 weeks
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Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Utredare
- Huvudutredare: Levent Karatas, Gazi University
Publikationer och användbara länkar
Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.
Allmänna publikationer
- Fransen M, McConnell S, Harmer AR, Van der Esch M, Simic M, Bennell KL. Exercise for osteoarthritis of the knee: a Cochrane systematic review. Br J Sports Med. 2015 Dec;49(24):1554-7. doi: 10.1136/bjsports-2015-095424. Epub 2015 Sep 24.
- Lespasio MJ, Piuzzi NS, Husni ME, Muschler GF, Guarino A, Mont MA. Knee Osteoarthritis: A Primer. Perm J. 2017;21:16-183. doi: 10.7812/TPP/16-183.
- Myers SS, Phillips RS, Davis RB, Cherkin DC, Legedza A, Kaptchuk TJ, Hrbek A, Buring JE, Post D, Connelly MT, Eisenberg DM. Patient expectations as predictors of outcome in patients with acute low back pain. J Gen Intern Med. 2008 Feb;23(2):148-53. doi: 10.1007/s11606-007-0460-5. Epub 2007 Dec 8.
- Jang S, Lee K, Ju JH. Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee. Int J Mol Sci. 2021 Mar 5;22(5):2619. doi: 10.3390/ijms22052619.
- Mondloch MV, Cole DC, Frank JW. Does how you do depend on how you think you'll do? A systematic review of the evidence for a relation between patients' recovery expectations and health outcomes. CMAJ. 2001 Jul 24;165(2):174-9.
- Levenig CG, Hasenbring MI, Gunnewig L, Titze C, Elsenbruch S, Schulte TL. Treatment Expectations-You Get What You Expect-and Depression Plays a Role. J Pain. 2024 Sep;25(9):104582. doi: 10.1016/j.jpain.2024.104582. Epub 2024 May 29.
- Robinson ME, Brown JL, George SZ, Edwards PS, Atchison JW, Hirsh AT, Waxenberg LB, Wittmer V, Fillingim RB. Multidimensional success criteria and expectations for treatment of chronic pain: the patient perspective. Pain Med. 2005 Sep-Oct;6(5):336-45. doi: 10.1111/j.1526-4637.2005.00059.x.
- Abdel-Aziz MA, Ahmed HMS, El-Nekeety AA, Abdel-Wahhab MA. Osteoarthritis complications and the recent therapeutic approaches. Inflammopharmacology. 2021 Dec;29(6):1653-1667. doi: 10.1007/s10787-021-00888-7. Epub 2021 Nov 9.
- Hsu H, Siwiec RM. Knee Osteoarthritis. 2023 Jun 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK507884/
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
1 januari 2026
Primärt slutförande (Beräknad)
1 september 2027
Avslutad studie (Beräknad)
15 september 2027
Studieregistreringsdatum
Först inskickad
24 maj 2026
Först inskickad som uppfyllde QC-kriterierna
24 maj 2026
Första postat (Faktisk)
1 juni 2026
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
10 juni 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
8 juni 2026
Senast verifierad
1 juni 2026
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