High-Intensity Interval Training vs Moderate-Intensity Continuous Training in Phase II Cardiac Rehabilitation
2026年6月1日 更新者：Riphah International University
Effects of High-Intensity Interval Training vs Moderate-Intensity Continuous Training on Ejection Fraction, Functional Capacity, and Lipid Profiles in Phase II Cardiac Rehabilitation
This randomized controlled trial aims to compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) in patients undergoing Phase II cardiac rehabilitation after coronary artery disease or post-angioplasty.
A total of 66 participants will be randomly allocated into two groups: HIIT (n=33) and MICT (n=33).
The intervention will be conducted 3 times per week using treadmill-based exercise protocols under heart rate monitoring.
Primary outcomes include changes in left ventricular ejection fraction, functional capacity measured by 6-minute walk test, and lipid profile parameters before and after intervention.
Secondary assessment includes health-related quality of life (HRQoL).
The study aims to determine which exercise modality provides superior cardiovascular and functional improvement in stable cardiac patients during supervised rehabilitation.
研究概览
地位
尚未招聘
条件
详细说明
This randomized controlled trial will compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) in patients undergoing Phase II cardiac rehabilitation after stable coronary artery disease or post-angioplasty. A total of 66 participants will be randomly assigned into two groups.
The HIIT group will perform treadmill-based interval exercise 3 times per week at 85-95% heart rate reserve with active recovery periods, while the MICT group will perform continuous treadmill exercise at 65-75% heart rate reserve for 30-45 minutes.
Primary outcomes include left ventricular ejection fraction (echocardiography), functional capacity (6-minute walk test), and lipid profile (LDL, HDL, triglycerides, total cholesterol) measured before and after intervention. Health-related quality of life (HRQoL) will also be assessed. The study aims to determine which exercise protocol produces greater improvement in cardiac and functional outcomes.
研究类型
介入性
注册 (估计的)
66
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习联系方式
- 姓名：Muhammad Iqbal Tariq, Phd*
- 电话号码：333826752
- 邮箱：iqbal.tariq@riphah.edu.pk
学习地点
-
-
Punjab Province
-
Multan、Punjab Province、巴基斯坦、60000
- Ch Pervaiz Elahi institute of cardiology Multan.
-
接触：
- Arjumand Bano, MS-CPPT
- 电话号码：03059551883
- 邮箱：arjumand.bano@riphah.edu.pk
-
首席研究员：
- ALISHBA JAVED, MS-CPPT
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 成人
接受健康志愿者
不
描述
Inclusion Criteria:
- Adults aged 18-60 years.
- Diagnosed with stable coronary artery disease confirmed by angiography, stress testing, or echocardiography.
- Left ventricular ejection fraction ≥45%.
- Functional NYHA Class I or II.
- Medically cleared by a cardiologist to participate in exercise (including recent ECG or stress test if necessary).
- Lightly active lifestyle prior to study (not involved in structured exercise programs).
Exclusion Criteria:
- Unstable angina or recent myocardial infarction (within the past 6 weeks).
- Uncontrolled hypertension (systolic BP >180 mmHg or diastolic BP >110 mmHg).
- Severe valvular heart disease, arrhythmias, or left ventricular dysfunction (EF <35%).
- Musculoskeletal disorders (e.g., severe osteoarthritis, recent fractures, or surgeries) preventing safe participation in exercise.
- Neurological disorders affecting mobility or safe exercise (e.g., stroke, Parkinson's disease).
- Uncontrolled diabetes mellitus (HbA1c >9% or recent hypoglycemia).
- Any other condition judged by the investigator to make participation unsafe.
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：High-Intensity Interval Training (HIIT)
Participants will perform supervised treadmill-based high-intensity interval training 3 sessions per week, including 10-minute warm-up, 4 intervals of 4 minutes at 85-95% heart rate reserve, 4-minute active recovery at 50-60% heart rate reserve, followed by 5-minute cool-down.
|
Participants will perform supervised treadmill-based high-intensity interval training 3 times per week.
Each session includes 10 minutes warm-up, 4 intervals of 4 minutes at 85-95% heart rate reserve, 4 minutes active recovery at 50-60% heart rate reserve, followed by 5 minutes cool-down.
其他名称：
|
|
有源比较器：Moderate-Intensity Continuous Training (MICT)
Participants will perform supervised treadmill-based continuous exercise 3 sessions per week at 65-75% heart rate reserve for 30-45 minutes, with warm-up and cool-down periods.
|
Participants will perform supervised treadmill-based continuous exercise 3 times per week at 65-75% heart rate reserve for 30-45 minutes, including warm-up and cool-down periods.
其他名称：
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Left Ventricular Ejection Fraction
大体时间：Baseline and at 12 weeks after intervention
|
Assessment of left ventricular ejection fraction using echocardiography to determine changes in cardiac function after intervention.
|
Baseline and at 12 weeks after intervention
|
|
Functional Capacity
大体时间：Baseline and at 12 weeks after intervention
|
Functional capacity will be measured by 6-minute walk test to evaluate distance covered during exercise tolerance assessment
|
Baseline and at 12 weeks after intervention
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Lipid Profile
大体时间：Baseline and at 12 weeks after intervention
|
Laboratory measurement of total cholesterol, LDL, HDL, and triglycerides to assess metabolic changes after exercise intervention.
|
Baseline and at 12 weeks after intervention
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员：Arjumand Bano, MSPT、Riphah International University
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (估计的)
2026年6月1日
初级完成 (估计的)
2026年8月1日
研究完成 (估计的)
2026年8月1日
研究注册日期
首次提交
2026年4月2日
首先提交符合 QC 标准的
2026年6月1日
首次发布 (实际的)
2026年6月2日
研究记录更新
最后更新发布 (实际的)
2026年6月2日
上次提交的符合 QC 标准的更新
2026年6月1日
最后验证
2026年6月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.