此页面是自动翻译的，不保证翻译的准确性。请参阅 英文版 对于源文本。

Rhythm Psychophysics With Parkinson's Patients (RPPD)

2026年6月9日 更新者：McMaster University

The goal of this interventional study is to understand how the rhythmic abilities of individuals in the early stages of Parkinson's Disease (PD) are impacted by their levels of dopamine. The main questions it aims to answer are:

  • Does dopamine shelter the ability to generate and maintain a regular tapping rhythm in the presence of disrupting sensory information?
  • Does dopamine allow the adaptation of tapping speed in the presence of changing sensory information?
  • Is the engagement of the motor system useful to improve the detection of changes in the tempo of sensory information?

Participants will be asked to perform a battery of simple rhythmic tasks On and Off medication to evaluate the effect of dopamine on their rhythmic skills.

研究概览

地位

尚未招聘

条件

干预/治疗

研究类型

介入性

注册 (估计的)

34

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

研究联系人备份

学习地点

  • 加拿大
    • Ontario
      • Hamilton、Ontario、加拿大、L8S 4L8
        • Psychology Building
        • 接触：
        • 接触：

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

  • 成人
  • 年长者

接受健康志愿者

不

描述

Inclusion Criteria:

  • Parkinson's Disease diagnostic
  • Stage 1 or 2 Hoenh-Yahr scale
  • Taking immediate-release Levodopa
  • MoCA score of 26 or above

Exclusion Criteria:

  • Dementia
  • Other neurodegenerative disease
  • History of substance abuse
  • History of hearing disorders
  • History of neuropsychiatric disease

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：基础科学
  • 分配：不适用
  • 介入模型：单组作业
  • 屏蔽：无（打开标签）

武器和干预

参与者组/臂
干预/治疗
实验性的：Medication state
Participants will have to attend two sessions scheduled approximately one week apart. During one session, participants will be tested while On medication (levodopa). During the other session, participants will be asked to withhold their medication for 12 hours prior to the experimental session. The order of the sessions will be randomized across participants.
药品：Withholding Levodopa
Participants will have to withhold Levodopa medication 12 h before one of two experimental sessions.

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Changes in mean inter-tap intervals following Levodopa withdrawal during rhythmic tapping tasks.
大体时间：Between experimental sessions one and two, which will take place approximately one week apart.
Audio recordings from the tapping tasks will be processed to extract onset times corresponding to participant taps (milliseconds). These onset times will be used to compute inter-tap intervals (ITI) by subtracting the earlier onset time from the later one (milliseconds).
Between experimental sessions one and two, which will take place approximately one week apart.
Changes in constant error following Levodopa withdrawal during rhythmic tapping tasks.
大体时间：Between experimental sessions one and two, which will take place approximately one week apart.
Audio recordings from the tapping tasks will be processed to extract the onset times of participant taps (milliseconds). These onset times will be used to compute the constant error (milliseconds) by subtracting the base interval (milliseconds) from the mean inter-tap interval (milliseconds).
Between experimental sessions one and two, which will take place approximately one week apart.
Changes in asynchronies following Levodopa withdrawal during rhythmic tapping tasks.
大体时间：Between experimental sessions one and two, which will take place approximately one week apart.
Audio recordings from the tapping tasks will be processed to extract onset times corresponding to auditory cues and participant taps (both in milliseconds). These onset times will be used to compute asynchronies (milliseconds) between the auditory cues and the taps. The asynchronies will be calculated by subtracting the tap onset from the corresponding auditory cue onset.
Between experimental sessions one and two, which will take place approximately one week apart.

次要结果测量

结果测量
措施说明
大体时间
Impact of Levodopa withdrawal on motor symptoms severity scales.
大体时间：Between experimental Sessions one and two, which will take place approximately one week apart.
Motor symptom severity will be assessed with Part III of the Unified Parkinson's Disease Rating Scale (UPDRS-III). Scores range from 0 to 132, with higher scores reflecting more severe motor symptoms.
Between experimental Sessions one and two, which will take place approximately one week apart.
Impact of Levodopa withdrawal on motor symptoms severity scales.
大体时间：Between experimental sessions one and two, which will take place approximately one week apart.
Cognitive assessment will be performed using the Scales for Outcomes in Parkinson's Disease-Cognition (SCOPA-COG). Scores range from 0 to 43, with higher scores reflecting better cognitive function.
Between experimental sessions one and two, which will take place approximately one week apart.

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

McMaster University

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (估计的)

2026年9月1日

初级完成 (估计的)

2027年9月30日

研究完成 (估计的)

2027年10月31日

研究注册日期

首次提交

2026年6月1日

首先提交符合 QC 标准的

2026年6月9日

首次发布 (实际的)

2026年6月15日

研究记录更新

最后更新发布 (实际的)

2026年6月15日

上次提交的符合 QC 标准的更新

2026年6月9日

最后验证

2026年5月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • 19513
  • RGEC27/2025 (其他赠款/资助编号：Human Frontiers Science Program)

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

未定

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

订阅