Improve Muscle Weakness in Patient With COPD
2026年6月11日 更新者：Hanan Hosny M Battesha、Al-Zaytoonah University of Jordan
Aerobic Exercise Combined With Blood Flow Restriction Improves Muscle Strength and Functional Capacity In Patients With Emphysematous COPD: A Randomized Controlled Trial
This randomized controlled trial investigated the effects of combining aerobic exercise with blood flow restriction (BFR) training in patients with emphysematous chronic obstructive pulmonary disease (COPD).
The study aimed to determine whether adding BFR to aerobic exercise could enhance muscle strength and functional capacity compared with conventional training alone.
The findings demonstrated that aerobic exercise combined with BFR significantly improved lower-limb muscle strength, exercise tolerance, and functional performance in patients with emphysematous COPD.
These results suggest that BFR-assisted aerobic training may serve as an effective and safe rehabilitation strategy to improve physical function and quality of life in this population.
研究概览
地位
尚未招聘
条件
研究类型
介入性
注册 (估计的)
60
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习联系方式
- 姓名：hanan mohamed
- 电话号码：+962775661825
- 邮箱：h.hosny@zuj.edu.jo
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
不
描述
Inclusion Criteria:
- Patients diagnosed with emphysematous chronic obstructive pulmonary disease (COPD).
- Clinically stable COPD patients with no acute exacerbation within the previous 4-6 weeks.
- Mild to moderate disease severity according to GOLD criteria.
- Ability to participate safely in aerobic exercise training.
- Medically stable and cleared by a physician for pulmonary rehabilitation.
- Ability to understand and follow study instructions.
Exclusion Criteria:
- Acute COPD exacerbation or respiratory infection during the study period.
- Severe cardiovascular diseases (e.g., unstable angina, uncontrolled hypertension, recent myocardial infarction).
- Peripheral vascular disease or contraindications to blood flow restriction (BFR) training.
- Severe musculoskeletal, neurological, or orthopedic disorders limiting exercise performance.
- Cognitive impairment affecting cooperation or informed consent.
- Participation in another structured rehabilitation program during the study period.
- Severe hypoxemia requiring continuous oxygen therapy during exercise.
- History of deep vein thrombosis or clotting disorders.
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：三倍
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：experimental group
aerobic exercise with blood flow restriction (BFR) training Procedure: Aerobic Exercise Training Device: Blood Flow Restriction Cuff
|
Aerobic exercise combined with blood flow restriction (BFR) is a rehabilitation technique in which patients perform low- to moderate-intensity aerobic exercise, such as treadmill or cycling training, while a specialized cuff is applied around the proximal part of the limb to partially restrict blood flow.
This method aims to enhance muscle strength and functional performance using lower exercise intensity, making it suitable for patients with limited exercise tolerance, such as individuals with COPD.
|
|
实验性的：control group
aerobic exercise
|
The control group performed conventional aerobic exercise training at low to moderate intensity without the application of blood flow restriction.
The program included activities such as treadmill walking or cycling to improve cardiovascular endurance, functional capacity, and overall physical fitness in patients with COPD.
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
muscle strength
大体时间：8 weeks
|
quadriceps strength by isokinetic: Quadriceps strength will be measured using an isokinetic dynamometer at an angular velocity of 60°/s.
Participants will perform three to five maximal concentric knee extension efforts after familiarization.
Peak torque (Nm) will be recorded, and the highest value will be used for statistical analysis
|
8 weeks
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
function capacity
大体时间：8 weeks
|
Functional capacity will be assessed using the 1-Minute Sit-to-Stand Test (1STS).
Participants will be instructed to sit and stand from a standard chair as many times as possible within one minute without using their upper limbs for assistance.
The total number of completed repetitions will be recorded, with higher scores indicating better functional capacity.
|
8 weeks
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (估计的)
2026年6月10日
初级完成 (估计的)
2026年8月15日
研究完成 (估计的)
2026年8月30日
研究注册日期
首次提交
2026年5月14日
首先提交符合 QC 标准的
2026年6月11日
首次发布 (实际的)
2026年6月16日
研究记录更新
最后更新发布 (实际的)
2026年6月16日
上次提交的符合 QC 标准的更新
2026年6月11日
最后验证
2026年6月1日
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- COPD
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
未定
药物和器械信息、研究文件
研究美国 FDA 监管的药品
不
研究美国 FDA 监管的设备产品
不
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.