Systemic Immune-Inflammation Index and Platelet Parameters in Diabetic Kidney Disease
Systemic Immune Inflammation Index With Related Blood Ratios and Platelet Parameters in Patients With Type 2 Diabetes Mellitus and Nephropathy
Diabetic kidney disease (DKD) is a frequent microvascular complication in individuals with type 2 diabetes mellitus (T2DM) and a major cause of chronic kidney failure worldwide. Chronic low-grade inflammation and platelet activation contribute significantly to renal microvascular damage.
The purpose of this observational study is to evaluate whether routine blood test markers, specifically the Systemic Immune-Inflammation Index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and platelet indices (such as mean platelet volume [MPV] and platelet distribution width [PDW]), can serve as simple, accessible, and cost-effective biomarkers for identifying the presence and progression of diabetic kidney disease.
Participants will include adult patients with type 2 diabetes categorized according to their urinary albumin-to-creatinine ratio (normoalbuminuria, microalbuminuria, and macroalbuminuria) as well as healthy control subjects. Complete blood counts, derived inflammatory indices, and renal parameters will be measured to assess their diagnostic accuracy for DKD.
研究概览
研究类型
注册 (估计的)
参与标准
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
取样方法
研究人群
描述
Inclusion Criteria:
- Adults aged 18 to 80 years, both males and females.
- Confirmed clinical diagnosis and history of Type 2 Diabetes Mellitus (T2DM).
- Healthy control subjects matched for age and sex (for the control cohort).
Exclusion Criteria:
- Type 1 diabetes mellitus.
- Acute infections or clinical signs of active inflammation at the time of sampling.
- Chronic inflammatory or autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus).
- Known or recently diagnosed malignancies.
- Chronic liver diseases, including cirrhosis or hepatitis.
- Nephrotic syndrome or other known non-diabetic kidney diseases.
- History of immunosuppressive therapy, systemic corticosteroids, or cytotoxic medications within the past 3 months prior to enrollment.
- Pregnancy.
- Significant cardiovascular complications.
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
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T2DM with Normoalbuminuria
30 adult patients diagnosed with type 2 diabetes mellitus presenting with normoalbuminuria, defined as urinary albumin-to-creatinine ratio (uACR) < 30 mg/g creatinine.
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T2DM with Microalbuminuria
30 adult patients diagnosed with type 2 diabetes mellitus presenting with microalbuminuria, defined as urinary albumin-to-creatinine ratio (uACR) between 30 and 299 mg/g creatinine.
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T2DM with Macroalbuminuria
30 adult patients diagnosed with type 2 diabetes mellitus presenting with macroalbuminuria, defined as urinary albumin-to-creatinine ratio (uACR) ≥ 300 mg/g creatinine.
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Healthy Controls
30 age- and sex-matched healthy control individuals without diabetes, renal impairment, or chronic inflammatory disease.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Systemic Immune-Inflammation Index (SII) Level
大体时间：Baseline
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Systemic Immune-Inflammation Index calculated as: Platelet count (10^9/L) × Neutrophil count (10^9/L) / Lymphocyte count (10^9/L).
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Baseline
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
关键字
其他相关的 MeSH 术语
其他研究编号
- SII and Platelets in DKD
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