Multi-Field-Strength MRI Brain Atlas Construction in Healthy Chinese Population
研究概览
详细说明
This is a prospective multi-field-strength neuroimaging study involving healthy Chinese adults. Eligible participants will undergo standardized brain MRI examinations at 0.55T, 1.5T, 3T, 5T, and 7T according to the study protocol.
MRI acquisitions include structural imaging, diffusion imaging, functional imaging, and quantitative imaging sequences where applicable. Images will undergo standardized preprocessing, registration, segmentation, and quantitative analysis. Multi-field-strength brain templates will be constructed, and anatomical and functional imaging characteristics will be compared across magnetic field strengths.
The study aims to establish normative multi-field-strength MRI reference data and brain atlases for healthy Chinese adults and to evaluate the consistency and field-strength-related differences in brain morphometry, cortical measurements, diffusion characteristics, functional connectivity, and other quantitative MRI parameters.
研究类型
注册 (估计的)
阶段
- 不适用
联系人和位置
学习联系方式
- 姓名：Ziheng Zhou
- 电话号码：+86 18710574531
- 邮箱：173416171@qq.com
学习地点
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Shaanxi
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Xi'an、Shaanxi、中国
- 招聘中
- Tangdu Hospital, Fourth Military Medical University
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接触：
- Shicao Li
- 电话号码：029-84717761
- 邮箱：tangduec@126.com
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参与标准
资格标准
适合学习的年龄
- 孩子
- 成人
- 年长者
接受健康志愿者
描述
Inclusion Criteria:
- Aged 16 to 66 years. Voluntarily participates in the study and provides written informed consent. No contraindications to MRI examination and able to cooperate with and complete the MRI examinations.
Female participants must not be pregnant. No current or previous clinical diagnosis of severe neurological or psychiatric disorders, such as schizophrenia, dementia, epilepsy, or severe sequelae of traumatic brain injury.
No obvious intracranial lesions or structural abnormalities identified on routine MRI examination.
Exclusion Criteria:
- Presence of contraindications to MRI examination, including MRI-incompatible implanted metallic or electronic devices, cochlear implants, cardiac pacemakers, intracranial metallic clips, or similar devices.
Severe claustrophobia preventing completion of the MRI examination. Pregnancy. Current or previous clinical diagnosis of severe neurological or psychiatric disorders.
History of severe head trauma, brain tumor, stroke, brain surgery, or other conditions that may substantially affect brain structure or function.
MRI data of insufficient quality for analysis due to marked discomfort, excessive head motion, or other causes during the examination.
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：Healthy Chinese Adults
Healthy Chinese adult volunteers will undergo standardized brain MRI examinations at multiple magnetic field strengths according to the study protocol.
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Participants will undergo standardized brain MRI examinations at 0.55T, 1.5T, 3T, 5T, and 7T.
MRI acquisitions include structural, diffusion, functional, and quantitative imaging sequences according to the study protocol.
No therapeutic intervention will be administered
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Regional Gray Matter Volume Across MRI Field Strengths
大体时间：From enrollment through completion of all scheduled multi-field-strength MRI examinations, up to 12 months
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Regional gray matter volumes will be quantified from standardized structural MRI data and compared across 0.55T, 1.5T, 3T, 5T, and 7T MRI acquisitions.
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From enrollment through completion of all scheduled multi-field-strength MRI examinations, up to 12 months
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- K202607-43
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
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