Multi-Field-Strength MRI Brain Atlas Construction in Healthy Chinese Population
Studieöversikt
Status
Betingelser
Intervention / Behandling
Detaljerad beskrivning
This is a prospective multi-field-strength neuroimaging study involving healthy Chinese adults. Eligible participants will undergo standardized brain MRI examinations at 0.55T, 1.5T, 3T, 5T, and 7T according to the study protocol.
MRI acquisitions include structural imaging, diffusion imaging, functional imaging, and quantitative imaging sequences where applicable. Images will undergo standardized preprocessing, registration, segmentation, and quantitative analysis. Multi-field-strength brain templates will be constructed, and anatomical and functional imaging characteristics will be compared across magnetic field strengths.
The study aims to establish normative multi-field-strength MRI reference data and brain atlases for healthy Chinese adults and to evaluate the consistency and field-strength-related differences in brain morphometry, cortical measurements, diffusion characteristics, functional connectivity, and other quantitative MRI parameters.
Studietyp
Inskrivning (Beräknad)
Fas
- Inte tillämpbar
Kontakter och platser
Studiekontakt
- Namn: Ziheng Zhou
- Telefonnummer: +86 18710574531
- E-post: 173416171@qq.com
Studieorter
-
-
Shaanxi
-
Xi'an, Shaanxi, Kina
- Rekrytering
- Tangdu Hospital, Fourth Military Medical University
-
Kontakt:
- Shicao Li
- Telefonnummer: 029-84717761
- E-post: tangduec@126.com
-
-
Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
- Barn
- Vuxen
- Äldre vuxen
Tar emot friska volontärer
Beskrivning
Inclusion Criteria:
- Aged 16 to 66 years. Voluntarily participates in the study and provides written informed consent. No contraindications to MRI examination and able to cooperate with and complete the MRI examinations.
Female participants must not be pregnant. No current or previous clinical diagnosis of severe neurological or psychiatric disorders, such as schizophrenia, dementia, epilepsy, or severe sequelae of traumatic brain injury.
No obvious intracranial lesions or structural abnormalities identified on routine MRI examination.
Exclusion Criteria:
- Presence of contraindications to MRI examination, including MRI-incompatible implanted metallic or electronic devices, cochlear implants, cardiac pacemakers, intracranial metallic clips, or similar devices.
Severe claustrophobia preventing completion of the MRI examination. Pregnancy. Current or previous clinical diagnosis of severe neurological or psychiatric disorders.
History of severe head trauma, brain tumor, stroke, brain surgery, or other conditions that may substantially affect brain structure or function.
MRI data of insufficient quality for analysis due to marked discomfort, excessive head motion, or other causes during the examination.
Studieplan
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Grundläggande vetenskap
- Tilldelning: N/A
- Interventionsmodell: Enskild gruppuppgift
- Maskning: Ingen (Open Label)
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
|
Experimentell: Healthy Chinese Adults
Healthy Chinese adult volunteers will undergo standardized brain MRI examinations at multiple magnetic field strengths according to the study protocol.
|
Participants will undergo standardized brain MRI examinations at 0.55T, 1.5T, 3T, 5T, and 7T.
MRI acquisitions include structural, diffusion, functional, and quantitative imaging sequences according to the study protocol.
No therapeutic intervention will be administered
|
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Regional Gray Matter Volume Across MRI Field Strengths
Tidsram: From enrollment through completion of all scheduled multi-field-strength MRI examinations, up to 12 months
|
Regional gray matter volumes will be quantified from standardized structural MRI data and compared across 0.55T, 1.5T, 3T, 5T, and 7T MRI acquisitions.
|
From enrollment through completion of all scheduled multi-field-strength MRI examinations, up to 12 months
|
Samarbetspartners och utredare
Sponsor
Samarbetspartners
Studieavstämningsdatum
Studera stora datum
Studiestart (Faktisk)
Primärt slutförande (Beräknad)
Avslutad studie (Beräknad)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Faktisk)
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Andra studie-ID-nummer
- K202607-43
Plan för individuella deltagardata (IPD)
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