Characterisation of MNEsic Involvement in Patients With Obesity. (MNEMOB)
The aim of the study is therefore to characterise memory impairment in a middle-aged population with obesity and to clarify the role of inflammation in obesity-related memory impairment.
The hypothesise that, as in an elderly population, neurological and memory impairment in a population of middle-aged obese individuals is heterogeneous, with varying levels of memory impairment characterised by neuropsychological test results. This heterogeneity in neuropsychological tests may be linked to markers of inflammation and brain imaging biomarkers identified previously in the litterature.
研究概览
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Blandine GATTA-CHERIFI, Pr
- 电话号码：+33 05 24 54 93 41
- 邮箱：blandine.gatta-cherifi@chu-bordeaux.fr
参与标准
资格标准
适合学习的年龄
- 成人
接受健康志愿者
取样方法
研究人群
Recruitment will take place within the Specialised Obesity Centre at Bordeaux University Hospital.
As part of their obesity treatment within the department, new patients first attend a consultation, after which they are usually admitted for a five-day educational programme to undergo a comprehensive initial multidisciplinary assessment (covering medical, dietary, psychological, physical activity and social aspects).
描述
Inclusion Criteria:
- Patients suffering from obesity with a BMI between 30 and 45 kg/m²
- Patients aged between 30 and 50 receiving educational care during the week at the CSO (Endocrinology, Diabetology and Nutrition Department) of the Bordeaux University Hospital.
- Right-handed patients
- Persons affiliated with or beneficiaries of a social security scheme.
- Free, informed and express consent
Exclusion Criteria:
- Patients currently undergoing treatment with neuroleptics or who have stopped treatment within the last 3 months.
- Pregnant or breastfeeding patients
- Known current or past neurological disease
- Proven depressive syndrome treated
- Patients with type 1 or type 2 diabetes
- Uncontrolled dysthyroidism
- MMS< 25
- Patients with proven genetic obesity
- Contraindication to MRI
- Chronic use of NSAIDs or corticosteroids
- Loss of 5% of body weight in the 3 months prior to the study
- Acute infection
- Persons deprived of their liberty by judicial or administrative decision
- Adults subject to legal protection measures (guardianship, curatorship, judicial protection)
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
Magnetic Resonance Imaging, CANTAB questionnaires
|
Magnetic resonance imaging (MRI) will collect anatomical information (3D T1 weighted images) to compute the volumes of the hypothalamus, hippocampus and the other brain parcels. Executive functions using the CANTAB tests and validated questionnaires will be performed. |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Memory function characteristic
大体时间：37 months after inclusion day
|
The main objective is to characterise memory function in a population of middle-aged individuals suffering from obesity using the CANTAB Paired Associates Learning (PAL) test.
|
37 months after inclusion day
|
合作者和调查者
调查人员
- 研究主任：Daniela COTA, Pr、INSERM u1215
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.