Myocardial Changes in Pediatric Guillain-Barré Syndrome
Myocardial Changes in Pediatric Patients With Guillain-Barré Syndrome
This prospective cohort study aims to identify and characterize cardiac changes including electrocardiographic, echocardiographic, and biochemical abnormalities in pediatric patients with Guillain-Barré syndrome.
研究概览
详细说明
Guillain-Barré syndrome can be associated with cardiac autonomic dysfunction and myocardial involvement. This observational study will include pediatric patients (1 month to 18 years) with confirmed Guillain-Barré syndrome.
Participants will undergo electrocardiography, echocardiography, and cardiac biomarker assessment at hospital admission and at 3-month follow-up.
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：maria m monir, Resident
- 电话号码：+20 10 20193392
- 邮箱：mariamedmagdy@gmail.com
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
Pediatric patients aged 1 month to 18 years with confirmed Guillain-Barré syndrome admitted to Assiut University Children's Hospital.
描述
Inclusion Criteria:
- Age 1 month to 18 years
- Confirmed diagnosis of Guillain-Barré syndrome
- Onset of neurological symptoms within 2 weeks prior to hospital presentation
- No pre-existing cardiac disease
- Written informed consent from parents or legal guardians
Exclusion Criteria:
- Pre-existing congenital or acquired heart disease
- Pre-existing neuromuscular disorders or hereditary peripheral neuropathies
- Incomplete cardiac workup (inability to perform ECG, echocardiography, and cardiac biomarker assessment)
- Loss to follow-up before hospital discharge
学习计划
研究是如何设计的？
设计细节
- 观测模型：COHORT
- 时间观点：PROSPECTIVE
队列和干预
团体/队列 |
|---|
|
Single cohort: Pediatric patients with Guillain-Barré syndrome
Pediatric patients with confirmed Guillain-Barré syndrome who will undergo cardiac evaluation at admission and at 3-month follow-up. |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Prevalence of cardiac abnormalities
大体时间：Baseline
|
Proportion of patients with any cardiac abnormality detected by electrocardiography, echocardiography, or elevated cardiac biomarkers (troponin I or CK-MB). |
Baseline
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Prevalence of electrocardiographic abnormalities
大体时间：Baseline
|
Proportion of patients with ECG abnormalities including rhythm disturbances, ST-segment changes, T-wave abnormalities, or conduction blocks. |
Baseline
|
|
Mean left ventricular ejection fraction (LVEF)
大体时间：Baseline
|
Mean left ventricular ejection fraction percentage measured by echocardiography. |
Baseline
|
|
Prevalence of elevated cardiac troponin I
大体时间：Baseline
|
Proportion of patients with elevated serum cardiac troponin I levels. |
Baseline
|
|
Prevalence of cardiac abnormalities at follow-up
大体时间：At 3 months
|
Proportion of patients with any cardiac abnormality detected by electrocardiography, echocardiography, or elevated cardiac biomarkers at 3-month follow-up. |
At 3 months
|
|
Mean left ventricular ejection fraction at follow-up
大体时间：At 3 months
|
Mean left ventricular ejection fraction percentage measured by echocardiography at 3-month follow-up. |
At 3 months
|
合作者和调查者
调查人员
- 学习椅：Faisal A Ahmed, prof、Pediatrics Department, Assiut University Hospitals
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- GBS-Cardiac-Assiut-2026
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
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研究美国 FDA 监管的设备产品
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