The Use of Infrared Cameras for Detecting Juvenile Idiopathic Arthritis (InfraAJI)
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children, causing persistent joint inflammation, pain, and functional impairment. Current monitoring relies on clinical scores, laboratory markers, and imaging, which are often resource intensive. Infrared thermography (IRT) is a non-invasive, radiation-free method that detects skin temperature changes potentially reflecting joint inflammation. Evidence in pediatric populations is limited, but IRT could provide an objective, reproducible, and child-friendly tool. This study aims to evaluate IRT's diagnostic accuracy by comparing it with clinical scores, laboratory markers, and ultrasound Doppler, to assess its utility as a complementary monitoring tool.
Patients with JIA will undergo clinical examination, routine blood tests, and IRT at baseline, 1 month, and 3 months. Control patients will participate in a single IRT session and, a CRP/ESR/blood test; if a biological workup is already planned as part of their routine care, existing results will be collected, and no additional sampling will be performed. IRT will follow a standardized protocol, including an acclimatization period, predefined positioning, and acquisition of three consecutive images per joint. After completion of the study, JIA patients will resume their standard-of-care follow-up.
研究概览
地位
研究类型
注册 (估计的)
阶段
- 不适用
联系人和位置
学习联系方式
- 姓名:Djamal-Dine DJEDDI, Pr
- 电话号码:33+322035590
- 邮箱:Djeddi.Djamal-Dine@chu-amiens.fr
学习地点
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-
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Amiens、法国、80480
- 招聘中
- CHRU Amiens
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接触:
- Djamal-Dine Djeddi, Pr
- 电话号码:33+322087632
- 邮箱:djeddi.djamal-dine@chu-amiens.fr
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副研究员:
- Maud ULLMO ULLMO, MD
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- children aged 2-16 years with clinically suspected arthritis affecting the knee, ankle, wrist, or hand, irrespective of disease stage,
- control group : children with non-inflammatory conditions and no history of autoimmune or inflammatory disease.
Exclusion Criteria:
- other inflammatory or non-inflammatory diseases or recent trauma/surgery explaining joint symptoms,
- local skin conditions interfering with infrared imaging, and treatments or comorbidities likely to alter joint or body temperature.
学习计划
研究是如何设计的?
设计细节
- 主要用途:放映
- 分配:非随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的:Patients with JIA
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Patients with JIA will undergo a standardized evaluation including a clinical joint examination, routine blood tests (CRP, NFS, ionogram, liver function, coagulation), and IRT of selected joints |
|
有源比较器:Control patients
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Control patients will undergo a single IRT session and a minimal blood test (CRP, ESP, blood count). IRT will be performed under controlled conditions with a defined joint positioning, 15-30 minutes of acclimatization, and acquisition of three consecutive images per joint. |
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
variation of IRT measure between both groups
大体时间:at baseline
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variation of IRT measure between both groups |
at baseline
|
|
variation of IRT measure between both groups
大体时间:at 1 month
|
variation of IRT measure between both groups |
at 1 month
|
|
variation of IRT measure between both groups
大体时间:at 3 months
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variation of IRT measure between both groups |
at 3 months
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
longitudinal changes in thermographic measurements
大体时间:at 3 months
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longitudinal changes in thermographic measurements by comparing temperature differences (ΔT) between baseline (D0) and 3 months |
at 3 months
|
|
correlation of longitudinal changes in thermographic measurements with clinical parameters
大体时间:at 3 months
|
at 3 months
|
|
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correlation of longitudinal changes in thermographic measurements with functional parameters
大体时间:at 3 months
|
at 3 months
|
|
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correlation of longitudinal changes in thermographic measurements with biological parameters
大体时间:at 3 months
|
at 3 months
|
|
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correlation of diagnostic performance of IRT with clinical examination
大体时间:at 3 months
|
at 3 months
|
|
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correlation of diagnostic performance of IRT with ultrasounds
大体时间:at 3 months
|
at 3 months
|
|
|
correlation of diagnostic performance of IRT with MRI
大体时间:at 3 months
|
at 3 months
|
|
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reproducibility of IRT measurements
大体时间:at 3 months
|
at 3 months
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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