Intraluminal Assessment of Coronary Arteries With Ferumoxytol-Enhanced Magnetic Resonance Angiography
Matthew S Chin, Michael Steigner, Wenqing Yin, Raymond Y Kwong, Andrew M Siedlecki, Matthew S Chin, Michael Steigner, Wenqing Yin, Raymond Y Kwong, Andrew M Siedlecki
No abstract availableKeywords: cardiovascular disease; ferumoxytol; kidney disease; magnetic resonance angiography.
Figures
![Figure 1. Three dimensional reconstruction of the…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5844804/bin/nihms919767f1.jpg)
(A) four chamber view, clockwise: main pulmonary artery, descending thoracic aorta, left ventricular chamber, right ventricular chamber, ascending thoracic aorta, (B) sagittal reconstruction with visualization of left coronary artery (arrow) and overlying main pulmonary artery, (C) multi-planar reconstruction of the coronary tree viewed superior to inferior showing distribution of [left to right, green lines], right coronary, left main continuous with left anterior descending artery, and left circumflex beginning at the level of the ascending aorta.
![Figure 2. Cardiac MRA directly following intravenous…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5844804/bin/nihms919767f2.jpg)
(A) [i]Left heart cardiac catheterization with demarcated section of left coronary artery [blue=proximal, red=distal] corresponds to MRA demarcation and Video 11, [ii] three dimensional reconstruction (with ventricular wall subtraction) showing path of vessel descent and axial cross section showing left lateral direction of vessel, *=aortic root. (B) [i] multi-planar straight-line and [ii] curvilinear reconstruction shows ferumoxytol-containing left main origin and LAD [green line], [iii] luminal cross section at the proximal (left) and distal (right) segment, respectively.
![Figure 3. Cardiac MRA directly following intravenous…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5844804/bin/nihms919767f3.jpg)
(A) [i] Right heart cardiac catheterization with demarcated section of right coronary artery [blue=proximal, red=distal] corresponds to MRA demarcation and Video 12, [ii] three dimensional reconstruction (with ventricular wall subtraction) showing path of vessel descent and axial cross section showing right lateral direction of vessel, *=aortic root. (B) [i] Multi-planar straight-line and [ii] curvilinear reconstruction shows patent, continuous, ferumoxytol-containing proximal-to-mid RCA [green line], [iii] luminal cross section at the proximal (left) and distal (right) segment, respectively, scale bar=5mm.
![Figure 4. fcMRA performed 185 days after…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5844804/bin/nihms919767f4.jpg)
(A) [i] Post-deployment coronary angiography with iodinated contrast identifies the stent (yellow arrow) in the left anterior descending artery proximal to the second diagonal branch and corresponds to MRA demarcation and Video 13 [ii] three dimensional reconstruction (with ventricular wall subtraction) and axial cross section showing left lateral direction of vessel, *=aortic root. (B)[i] Multi-planar straight-line and [ii] curvilinear reconstruction shows ferumoxytol-containing LAD, yellow bar = stent, [iii] luminal cross section at the proximal (left) and distal (right) segment, respectively.
![Figure 5. fcMRA performed 185 days after…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5844804/bin/nihms919767f5.jpg)
(A) [i] 70% mid-right coronary artery lesion (red arrow) is visualized by right coronary artery catheterization and corresponds to MRA demarcation and Video 14, [ii] three dimensional reconstruction (with ventricular wall subtraction) and axial cross section showing left lateral direction of vessel, *=aortic root. (B) [i] Multi-planar straight-line and [ii] curvilinear reconstruction shows RCA luminal stenosis [red arrow], [iii] luminal cross section at the proximal (left) and distal(right) segment, respectively, scale bar=5mm.
![Figure 6. Origins of right and left…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5844804/bin/nihms919767f6.jpg)
Axial cross section of right coronary origin (first column), and sagittal cross sections of left main artery origin (second column), and representative segments of left anterior descending (LAD)(third column) and left circumflex (fourth column) (red arrows), traced to their most distal points in corresponding Videos 1–10 in the axial and sagittal planes, respectively (Patient 1 = video 1,2; Patient 2 = video 3,4; Patient 3 = video 5,6; Patient 4 = video 7,8; Patient 5 = video 9,10). Patients 1–4 were in sinus rhythm throughout the study while Patient 5 was in atrial fibrillation. Patient 4 was 122.5 kg and weighed at least 34.3% more than Patients 1–3. Mean continuous length of left and right coronary circulation measured was 6.53±1.26 cm and 6.08±2.8 cm(n=5) from respective origins also summarized in Supplemental Table 1.
Source: PubMed