Combined general-epidural anesthesia with continuous postoperative epidural analgesia preserves sigmoid colon perfusion in elective infrarenal aortic aneurysm repair

Venetiana Panaretou, Ioanna Siafaka, Dimitrios Theodorou, Andreas Manouras, Charalampos Seretis, Stavros Gourgiotis, Stylianos Katsaragakis, Fragiska Sigala, George Zografos, Konstantinos Filis, Venetiana Panaretou, Ioanna Siafaka, Dimitrios Theodorou, Andreas Manouras, Charalampos Seretis, Stavros Gourgiotis, Stylianos Katsaragakis, Fragiska Sigala, George Zografos, Konstantinos Filis

Abstract

Background: In elective open infrarenal aortic aneurysm repair the use of epidural anesthesia and analgesia may preserve splanchnic perfusion. The aim of this study was to investigate the effects of epidural anesthesia on gut perfusion with gastrointestinal tonometry in patients undergoing aortic reconstructive surgery.

Methods: THIRTY PATIENTS, SCHEDULED TO UNDERGO AN ELECTIVE INFRARENAL ABDOMINAL AORTIC RECONSTRUCTIVE PROCEDURE WERE RANDOMIZED IN TWO GROUPS: the epidural anesthesia group (Group A, n=16) and the control group (Group B, n=14). After induction of anesthesia, a transanally inserted sigmoid tonometer was placed for the measurement of sigmoid and gastric intramucosal CO2 levels and the calculation of regional-arterial CO2 difference (ΔPCO2). Additional measurements included mean arterial pressure (MAP), cardiac output (CO), systemic vascular resistance (SVR), and arterial lactate levels.

Results: There were no significant intra- and inter-group differences for MAP, CO, SVR, and arterial lactate levels. Sigmoid pH and PCO2 increased in both the groups, but this increase was significantly higher in Group B, 20 min after aortic clamping and 10 min after aortic declamping.

Conclusions: Patients receiving epidural anesthesia during abdominal aortic reconstruction appear to have less severe disturbances of sigmoid perfusion compared with patients not receiving epidural anesthesia. Further studies are needed to verify these results.

Keywords: Anesthesia; aorta; epidural analgesia; intestinal tonometry; splanchnic perfusion.

Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Monitoring and fluctuation of cardiac output (a) systematic vascular resistance (b) and mean arterial pressure (c) between groups A and B (T0– T8)
Figure 2
Figure 2
Sigmoid pH (a) PCO2 (b) and ΔPCO2 (c) values between groups A and B during the observation period T1–T8
Figure 3
Figure 3
Comparison of arterial lactate levels between groups A and B (T0–T8)

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Source: PubMed

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