Resolving Neurodevelopmental and Vision Disorders Using Organoid Single-Cell Multi-omics
Giovanna Brancati, Barbara Treutlein, J Gray Camp, Giovanna Brancati, Barbara Treutlein, J Gray Camp
Abstract
Human organoid models of the central nervous system, including the neural retina, are providing unprecedented opportunities to explore human neurodevelopment and neurodegeneration in controlled culture environments. In this Perspective, we discuss how the single-cell multi-omic toolkit has been used to identify features and limitations of brain and retina organoids and how these tools can be deployed to study congenital brain malformations and vision disorders in organoids. We also address how to improve brain and retina organoid protocols to revolutionize in vitro disease modeling.
Keywords: cerebral organoids; disease modeling; retinal organoids; single-cell genomics; stem cells.
Copyright © 2020 Elsevier Inc. All rights reserved.
Source: PubMed