Interventions for improving adherence to treatment for latent tuberculosis infection: a systematic review

Anke L Stuurman, Marije Vonk Noordegraaf-Schouten, Femke van Kessel, Anouk M Oordt-Speets, Andreas Sandgren, Marieke J van der Werf, Anke L Stuurman, Marije Vonk Noordegraaf-Schouten, Femke van Kessel, Anouk M Oordt-Speets, Andreas Sandgren, Marieke J van der Werf

Abstract

Background: Latent tuberculosis infection (LTBI) control relies on high initiation and completion rates of preventive treatment to preclude progression to tuberculosis disease. Specific interventions may improve initiation and completion rates. The objective was to systematically review data on determinants of initiation, adherence and completion of LTBI treatment, and on interventions to improve initiation and completion.

Methods: A systematic review of the literature (PubMed, Embase) published up to February 2014 was performed. Relevant prospective intervention studies were assessed using GRADE.

Results: Sixty-two articles reporting on determinants of treatment initiation and completion were included and 23 articles on interventions. Determinants of LTBI treatment completion include shorter treatment regimen and directly observed treatment (DOT, positive association), adverse events and alcohol use (negative association), and specific populations with LTBI (both positive and negative associations). A positive effect on completion was noted in intervention studies that used short regimens and social interventions; mixed results were found for intervention studies that used DOT or incentives.

Conclusion: LTBI treatment completion can be improved by using shorter regimens and social interventions. Specific needs of the different populations with LTBI should be addressed taking into consideration the setting and condition in which the LTBI treatment programme is implemented.

Keywords: Latent tuberculosis; Risk groups; Treatment adherence; Treatment completion; Treatment initiation; Tuberculosis.

Figures

Fig. 1
Fig. 1
Forest plot for adherence to short vs. long LTBI treatment in case contacts with LTBI
Fig. 2
Fig. 2
Forest plot for completion of short vs. long LTBI treatment in the general population diagnosed with LTBI
Fig. 3
Fig. 3
Forest plot for completion of LTBI treatment using social interventions in the general population diagnosed with LTBI

References

    1. Lillebaek T, Dirksen A, Baess I, Strunge B, Thomsen VO, Andersen AB. Molecular evidence of endogenous reactivation of Mycobacterium tuberculosis after 33 years of latent infection. J Infect Dis. 2002;185:401–4. doi: 10.1086/338342.
    1. Barry CE, 3rd, Boshoff HI, Dartois V, et al. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nat Rev Microbiol. 2009;7:845–55.
    1. Dye C, Scheele S, Dolin P, Pathania V, Raviglione MC. Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA. 1999;282:677–86. doi: 10.1001/jama.282.7.677.
    1. World Health Organization. The END TB strategy - Global strategy and targets for tuberculosis prevention, care and control after 2015. In: Geneva: WHO, ed, 2014:2.
    1. World Health Organization . Draft global strategy and targets for tuberculosis prevention, care and control after 2015. In: Secretariat, editor. World Health Assembly. Geneva: WHO; 2014.
    1. Adams LV, Talbot EA, Odato K, Blunt H, Steingart KR. Interventions to improve delivery of isoniazid preventive therapy: an overview of systematic reviews. BMC Infect Dis. 2014;14:281. doi: 10.1186/1471-2334-14-281.
    1. M’Imunya JM, Kredo T, Volmink J. Patient education and counselling for promoting adherence to treatment for tuberculosis. Cochrane Database Syst Rev. 2012;5:CD006591.
    1. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353:487–97. doi: 10.1056/NEJMra050100.
    1. Sharma SK, Sharma A, Kadhiravan T, Tharyan P. Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV-negative people at risk of active TB. Cochrane Database Syst Rev. 2013;7:CD007545.
    1. DeFulio A, Silverman K. The use of incentives to reinforce medication adherence. Prev Med. 2012;55(Suppl):S86–94. doi: 10.1016/j.ypmed.2012.04.017.
    1. World Health Organization . Guidelines on the management of latent tuberculosis infection. The End TB Strategy: WHO; 2015.
    1. Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines 6. Rating the quality of evidence—imprecision. J Clin Epidemiol. 2011;64:1283–93. doi: 10.1016/j.jclinepi.2011.01.012.
    1. Cochrane Informatics & Knowledge Management Department. GRADEpro. Available at: . Accessed April 29 2014.
    1. Neyeloff JL, Fuchs SC, Moreira LB. Meta-analyses and Forest plots using a microsoft excel spreadsheet: step-by-step guide focusing on descriptive data analysis. BMC Res Notes. 2012;5:52. doi: 10.1186/1756-0500-5-52.
    1. White MC, Tulsky JP, Goldenson J, Portillo CJ, Kawamura M, Menendez E. Randomized controlled trial of interventions to improve follow-up for latent tuberculosis infection after release from jail. Arch Intern Med. 2002;162:1044–50. doi: 10.1001/archinte.162.9.1044.
    1. Batki SL, Gruber VA, Bradley JM, Bradley M, Delucchi K. A controlled trial of methadone treatment combined with directly observed isoniazid for tuberculosis prevention in injection drug users. Drug Alcohol Depend. 2002;66:283–93. doi: 10.1016/S0376-8716(01)00208-3.
    1. Chaisson RE, Barnes GL, Hackman J, et al. A randomized, controlled trial of interventions to improve adherence to isoniazid therapy to prevent tuberculosis in injection drug users. Am J Med. 2001;110:610–5. doi: 10.1016/S0002-9343(01)00695-7.
    1. Goldberg SV, Wallace J, Jackson JC, Chaulk CP, Nolan CM. Cultural case management of latent tuberculosis infection. Int J Tuberc Lung Dis. 2004;8:76–82.
    1. Hovell MF, Sipan CL, Blumberg EJ, et al. Increasing Latino adolescents’ adherence to treatment for latent tuberculosis infection: a controlled trial. Am J Public Health. 2003;93:1871–7. doi: 10.2105/AJPH.93.11.1871.
    1. Sterling TR, Villarino ME, Borisov AS, et al. Three months of rifapentine and isoniazid for latent tuberculosis infection. N Engl J Med. 2011;365:2155–66. doi: 10.1056/NEJMoa1104875.
    1. Tortajada C, Martinez-Lacasa J, Sanchez F, et al. Is the combination of pyrazinamide plus rifampicin safe for treating latent tuberculosis infection in persons not infected by the human immunodeficiency virus? Int J Tuberc Lung Dis. 2005;9:276–81.
    1. Gershon AS, McGeer A, Bayoumi AM, Raboud J, Yang J. Health care workers and the initiation of treatment for latent tuberculosis infection. Clin Infect Dis. 2004;39:667–72. doi: 10.1086/422995.
    1. Horsburgh CR, Jr, Goldberg S, Bethel J, et al. Latent TB infection treatment acceptance and completion in the United States and Canada. Chest. 2010;137:401–9. doi: 10.1378/chest.09-0394.
    1. Goswami ND, Gadkowski LB, Piedrahita C, et al. Predictors of latent tuberculosis treatment initiation and completion at a U.S. public health clinic: a prospective cohort study. BMC Public Health. 2012;12:468. doi: 10.1186/1471-2458-12-468.
    1. Morano JP, Walton MR, Zelenev A, Bruce RD, Altice FL. Latent tuberculosis infection: screening and treatment in an urban setting. J Community Health. 2013;38:941–50. doi: 10.1007/s10900-013-9704-y.
    1. Nuzzo JB, Golub JE, Chaulk P, Shah M. Analysis of latent tuberculosis infection treatment adherence among refugees and other patient groups referred to the Baltimore City Health Department TB Clinic, February 2009-March 2011. J Immigr Minor Health. 2013;17(1):56-65.
    1. Kominski GF, Varon SF, Morisky DE, et al. Costs and cost-effectiveness of adolescent compliance with treatment for latent tuberculosis infection: results from a randomized trial. J Adolesc Health. 2007;40:61–8. doi: 10.1016/j.jadohealth.2006.08.012.
    1. Chang AH, Polesky A, Bhatia G. House calls by community health workers and public health nurses to improve adherence to isoniazid monotherapy for latent tuberculosis infection: a retrospective study. BMC Public Health. 2013;13:894. doi: 10.1186/1471-2458-13-894.
    1. Haley CA, Stephan S, Vossel LF, Sherfy EA, Laserson KF, Kainer MA. Successful use of rifampicin for Hispanic foreign-born patients with latent tuberculosis infection. Int J Tuberc Lung Dis. 2008;12:160–7.
    1. LoBue PA, Moser KS. Use of isoniazid for latent tuberculosis infection in a public health clinic. Am J Respir Crit Care Med. 2003;168:443–7. doi: 10.1164/rccm.200303-390OC.
    1. Li J, Munsiff SS, Tarantino T, Dorsinville M. Adherence to treatment of latent tuberculosis infection in a clinical population in New York City. Int J Infect Dis. 2010;14:e292–7. doi: 10.1016/j.ijid.2009.05.007.
    1. Hirsch-Moverman Y, Bethel J, Colson PW, Franks J, El-Sadr W. Predictors of latent tuberculosis infection treatment completion in the United States: an inner city experience. Int J Tuberc Lung Dis. 2010;14:1104–11.
    1. Codecasa LR, Murgia N, Ferrarese M, et al. Isoniazid preventive treatment: predictors of adverse events and treatment completion. Int J Tuberc Lung Dis. 2013;17:903–8. doi: 10.5588/ijtld.12.0677.
    1. Lee AM, Mennone JZ, Jones RC, Paul WS. Risk factors for hepatotoxicity associated with rifampin and pyrazinamide for the treatment of latent tuberculosis infection: experience from three public health tuberculosis clinics. Int J Tuberc Lung Dis. 2002;6:995–1000.
    1. Nyamathi AM, Christiani A, Nahid P, Gregerson P, Leake B. A randomized controlled trial of two treatment programs for homeless adults with latent tuberculosis infection. Int J Tuberc Lung Dis. 2006;10:775–82.
    1. Anibarro L, Casas S, Paz-Esquete J, et al. Treatment completion in latent tuberculosis infection at specialist tuberculosis units in Spain. Int J Tuberc Lung Dis. 2010;14:701–7.
    1. Lobato MN, Reves RR, Jasmer RM, Grabau JC, Bock NN, Shang N. Adverse events and treatment completion for latent tuberculosis in jail inmates and homeless persons. Chest. 2005;127:1296–303.
    1. Jimenez-Fuentes MA, de Souza-Galvao ML, Mila Auge C, Solsona Peiro J, Altet-Gomez MN. Rifampicin plus isoniazid for the prevention of tuberculosis in an immigrant population. Int J Tuberc Lung Dis. 2013;17:326–32. doi: 10.5588/ijtld.12.0510.
    1. Fresard I, Bridevaux PO, Rochat T, Janssens JP. Adverse effects and adherence to treatment of rifampicin 4 months vs isoniazid 6 months for latent tuberculosis: a retrospective analysis. Swiss Med Wkly. 2011;141:w13240.
    1. Lardizabal A, Passannante M, Kojakali F, Hayden C, Reichman LB. Enhancement of treatment completion for latent tuberculosis infection with 4 months of rifampin. Chest. 2006;130:1712–7. doi: 10.1378/chest.130.6.1712.
    1. Page KR, Sifakis F, Montes de Oca R, et al. Improved adherence and less toxicity with rifampin vs isoniazid for treatment of latent tuberculosis: a retrospective study. Arch Intern Med. 2006;166:1863–70. doi: 10.1001/archinte.166.17.1863.
    1. Young H, Wessolossky M, Ellis J, Kaminski M, Daly JS. A retrospective evaluation of completion rates, total cost, and adverse effects for treatment of latent tuberculosis infection in a public health clinic in central massachusetts. Clin Infect Dis. 2009;49:424–7. doi: 10.1086/600394.
    1. Bastos ML, Menzies D, Belo MT, et al. Changes in QuantiFERON(R)-TB Gold In-Tube results during treatment for tuberculous infection. Int J Tuberc Lung Dis. 2013;17:909–16. doi: 10.5588/ijtld.12.0927.
    1. White MC, Gournis E, Kawamura M, Menendez E, Tulsky JP. Effect of directly observed preventive therapy for latent tuberculosis infection in San Francisco. Int J Tuberc Lung Dis. 2003;7:30–5.
    1. Cruz AT, Starke JR. Increasing adherence for latent tuberculosis infection therapy with health department-administered therapy. Pediatr Infect Dis J. 2012;31:193–5. doi: 10.1097/INF.0b013e318236984f.
    1. Chang SH, Eitzman SR, Nahid P, Finelli ML. Factors associated with failure to complete isoniazid therapy for latent tuberculosis infection in children and adolescents. J Infect Public Health. 2014;7:145–52. doi: 10.1016/j.jiph.2013.11.001.
    1. Kwara A, Herold JS, Machan JT, Carter EJ. Factors associated with failure to complete isoniazid treatment for latent tuberculosis infection in Rhode Island. Chest. 2008;133:862–8. doi: 10.1378/chest.07-2024.
    1. Vinnard C, Gopal A, Linkin DR, Maslow J. Isoniazid Toxicity among an Older Veteran Population: A Retrospective Cohort Study. Tuberc Res Treat. 2013;2013:549473.
    1. Gilroy SA, Rogers MA, Blair DC. Treatment of latent tuberculosis infection in patients aged > or =35 years. Clin Infect Dis. 2000;31:826–9. doi: 10.1086/314037.
    1. Spyridis NP, Spyridis PG, Gelesme A, et al. The effectiveness of a 9-month regimen of isoniazid alone versus 3- and 4-month regimens of isoniazid plus rifampin for treatment of latent tuberculosis infection in children: results of an 11-year randomized study. Clin Infect Dis. 2007;45:715–22. doi: 10.1086/520983.
    1. Jasmer RM, Saukkonen JJ, Blumberg HM, et al. Short-course rifampin and pyrazinamide compared with isoniazid for latent tuberculosis infection: a multicenter clinical trial. Ann Intern Med. 2002;137:640–7. doi: 10.7326/0003-4819-137-8-200210150-00007.
    1. Menzies D, Dion MJ, Rabinovitch B, Mannix S, Brassard P, Schwartzman K. Treatment completion and costs of a randomized trial of rifampin for 4 months versus isoniazid for 9 months. Am J Respir Crit Care Med. 2004;170:445–9. doi: 10.1164/rccm.200404-478OC.
    1. Menzies D, Long R, Trajman A, et al. Adverse events with 4 months of rifampin therapy or 9 months of isoniazid therapy for latent tuberculosis infection: a randomized trial. Ann Intern Med. 2008;149:689–97. doi: 10.7326/0003-4819-149-10-200811180-00003.
    1. Matteelli A, Casalini C, Raviglione MC, et al. Supervised preventive therapy for latent tuberculosis infection in illegal immigrants in Italy. Am J Respir Crit Care Med. 2000;162:1653–5. doi: 10.1164/ajrccm.162.5.9912062.
    1. Malotte CK, Hollingshead JR, Larro M. Incentives vs outreach workers for latent tuberculosis treatment in drug users. Am J Prev Med. 2001;20:103–7. doi: 10.1016/S0749-3797(00)00283-X.
    1. Tulsky JP, Hahn JA, Long HL, et al. Can the poor adhere? Incentives for adherence to TB prevention in homeless adults. Int J Tuberc Lung Dis. 2004;8:83–91.
    1. Ailinger RL, Martyn D, Lasus H, Lima GN. The effect of a cultural intervention on adherence to latent tuberculosis infection therapy in Latino immigrants. Public Health Nurs. 2010;27:115–20. doi: 10.1111/j.1525-1446.2010.00834.x.
    1. Hirsch-Moverman Y, Colson PW, Bethel J, Franks J, El-Sadr WM. Can a peer-based intervention impact adherence to the treatment of latent tuberculous infection? Int J Tuberc Lung Dis. 2013;17:1178–85. doi: 10.5588/ijtld.12.0823.
    1. Sahni R, Miranda C, Yen-Lieberman B, et al. Does the implementation of an interferon-gamma release assay in lieu of a tuberculin skin test increase acceptance of preventive therapy for latent tuberculosis among healthcare workers? Infect Control Hosp Epidemiol. 2009;30:197–9. doi: 10.1086/593965.
    1. Cass AD, Talavera GA, Gresham LS, Moser KS, Joy W. Structured behavioral intervention to increase children’s adherence to treatment for latent tuberculosis infection. Int J Tuberc Lung Dis. 2005;9:415–20.
    1. Sabaté E e. Adherence to long-term therapies: evidence for action. In: Sabaté E, ed. Geneva: World Health Organization; 2003.
    1. Bowry AD, Shrank WH, Lee JL, Stedman M, Choudhry NK. A systematic review of adherence to cardiovascular medications in resource-limited settings. J Gen Intern Med. 2011;26:1479–91. doi: 10.1007/s11606-011-1825-3.
    1. Lemstra M, Blackburn D, Crawley A, Fung R. Proportion and risk indicators of nonadherence to statin therapy: a meta-analysis. CanJ Cardiol. 2012;28:574–80. doi: 10.1016/j.cjca.2012.05.007.
    1. Malta M, Magnanini MM, Strathdee SA, Bastos FI. Adherence to antiretroviral therapy among HIV-infected drug users: a meta-analysis. AIDS Behav. 2010;14:731–47. doi: 10.1007/s10461-008-9489-7.
    1. Lemstra M, Alsabbagh MW. Proportion and risk indicators of nonadherence to antihypertensive therapy: a meta-analysis. Patient Preference Adherence. 2014;8:211–8. doi: 10.2147/PPA.S55382.
    1. Centers for Disease Control and Prevention, American Thoracic Society. Update: adverse event data and revised American Thoracic Society/CDC recommendations against the use of rifampin and pyrazinamide for treatment of latent tuberculosis infection--United States, 2003. MMWR Morb Mortal Wkly Rep. 2003; 52:735-9.
    1. Ford N, Nachega JB, Engel ME, Mills EJ. Directly observed antiretroviral therapy: a systematic review and meta-analysis of randomised clinical trials. Lancet. 2009;374:2064–71. doi: 10.1016/S0140-6736(09)61671-8.
    1. Volmink J, Garner P. Directly observed therapy for treating tuberculosis. Cochrane Database Syst Rev. 2007;(4):Cd003343.
    1. Lutge EE, Wiysonge CS, Knight SE, Volmink J. Material incentives and enablers in the management of tuberculosis. Cochrane Database Syst Rev. 2012;1:CD007952.
    1. Schroeder K, Fahey T, Ebrahim S. How can we improve adherence to blood pressure-lowering medication in ambulatory care? Systematic review of randomized controlled trials. Arch Intern Med. 2004;164:722–32. doi: 10.1001/archinte.164.7.722.
    1. Schedlbauer A, Schroeder K, Fahey T. How can adherence to lipid-lowering medication be improved? A systematic review of randomized controlled trials. Fam Pract. 2007;24:380–7. doi: 10.1093/fampra/cmm030.
    1. Lewin S, Munabi-Babigumira S, Glenton C, et al. Lay health workers in primary and community health care for maternal and child health and the management of infectious diseases. Cochrane Database Syst Rev. 2010;CD004015.
    1. Hwang SW, Tolomiczenko G, Kouyoumdjian FG, Garner RE. Interventions to improve the health of the homeless: a systematic review. Am J Prev Med. 2005;29:311–9. doi: 10.1016/j.amepre.2005.06.017.
    1. Stagg HR, Zenner D, Harris RJ, Munoz L, Lipman MC, Abubakar I. Treatment of latent tuberculosis infection: a network meta-analysis. Ann Intern Med. 2014;161:419–28. doi: 10.7326/M14-1019.
    1. Hovell M, Blumberg E, Gil-Trejo L, et al. Predictors of adherence to treatment for latent tuberculosis infection in high-risk Latino adolescents: a behavioral epidemiological analysis. Soc Sci Med. 2003;56:1789–96. doi: 10.1016/S0277-9536(02)00176-4.
    1. Berg J, Blumberg EJ, Sipan CL, et al. Somatic complaints and isoniazid (INH) side effects in Latino adolescents with latent tuberculosis infection (LTBI) Patient Educ Couns. 2004;52:31–9. doi: 10.1016/S0738-3991(02)00268-9.
    1. Fountain FF, Tolley E, Chrisman CR, Self TH. Isoniazid hepatotoxicity associated with treatment of latent tuberculosis infection: A 7-year evaluation from a public health tuberculosis clinic. Chest. 2005;128:116–23. doi: 10.1378/chest.128.1.116.
    1. Morisky DE, Ebin VJ, Malotte CK, Coly A, Kominski G. Assessment of tuberculosis treatment completion in an ethnically diverse population using two data sources. Implications for treatment interventions. Eval Health Prof. 2003;26:43–58. doi: 10.1177/0163278702250080.
    1. Rennie TW, Bothamley GH, Engova D, Bates IP. Patient choice promotes adherence in preventive treatment for latent tuberculosis. Eur Respir J. 2007;30:728–35. doi: 10.1183/09031936.00034007.
    1. Parsyan AE, Saukkonen J, Barry MA, Sharnprapai S, Horsburgh CR., Jr Predictors of failure to complete treatment for latent tuberculosis infection. J Infect. 2007;54:262–6. doi: 10.1016/j.jinf.2006.04.010.
    1. McElroy PD, Ijaz K, Lambert LA, et al. National survey to measure rates of liver injury, hospitalization, and death associated with rifampin and pyrazinamide for latent tuberculosis infection. Clin Infect Dis. 2005;41:1125–33. doi: 10.1086/444463.
    1. Kan B, Kalin M, Bruchfeld J. Completing treatment for latent tuberculosis: patient background matters. Int J Tuberc Lung Dis. 2013;17:597–602. doi: 10.5588/ijtld.12.0692.
    1. Shieh FK, Snyder G, Horsburgh CR, Bernardo J, Murphy C, Saukkonen JJ. Predicting non-completion of treatment for latent tuberculous infection: a prospective survey. Am J Respir Crit Care Med. 2006;174:717–21. doi: 10.1164/rccm.200510-1667OC.

Source: PubMed

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