Statin therapy is associated with improved survival after endovascular and open aneurysm repair
Jorg L de Bruin, Annette F Baas, Martijn W Heymans, Mathijs G Buimer, Monique Prinssen, Diederick E Grobbee, Jan D Blankensteijn, DREAM Study Group, D E Grobbee, J D Blankensteijn, A A A Bak, J Buth, P M Pattynama, E L G Verhoeven, A E van Voorthuisen, J D Blankensteijn, R Balm, J Buth, P W M Cuypers, D E Grobbee, M Prinssen, M R H M van Sambeek, E L G Verhoeven, A F Baas, M G Hunink, J M van Engelshoven, M J H M Jacobs, B A J M de Mol, J H van Bockel, R Balm, J Reekers, X Tielbeek, E L G Verhoeven, W Wisselink, N Boekema, L M Heuveling, I Sikking, M Prinssen, R Balm, J D Blankensteijn, J Buth, P W M Cuypers, M R H M van Sambeek, E L G Verhoeven, J L de Bruin, A F Baas, J D Blankensteijn, M Prinssen, J Buth, A V Tielbeek, J D Blankensteijn, R Balm, J A Reekers, M R H M van Sambeek, P Pattynama, E L G Verhoeven, T Prins, A C van der Ham, J J I M van der Velden, S M M van Sterkenburg, G B ten Haken, C M A Bruijninckx, H van Overhagen, R P Tutein Nolthenius, T R Hendriksz, J A W Teijink, H F Odink, A A E A de Smet, D Vroegindeweij, Jeroen Bosch, R M M van Loenhout, M J Rutten, J F Hamming, L E H Lampmann, M H M Bender, H Pasmans, A C Vahl, C de Vries, A J C Mackaay, L M C van Dortmont, A J van der Vliet, L J Schultze Kool, J H B Boomsma, H R van Dop, J C A de Mol van Otterloo, T P W de Rooij, T M Smits, E N Yilmaz, W Wisselink, F G van den Berg, M J T Visser, E van der Linden, G W H Schurink, M de Haan, H J Smeets, P Stabel, F van Elst, J Poniewierski, F E G Vermassen, Jorg L de Bruin, Annette F Baas, Martijn W Heymans, Mathijs G Buimer, Monique Prinssen, Diederick E Grobbee, Jan D Blankensteijn, DREAM Study Group, D E Grobbee, J D Blankensteijn, A A A Bak, J Buth, P M Pattynama, E L G Verhoeven, A E van Voorthuisen, J D Blankensteijn, R Balm, J Buth, P W M Cuypers, D E Grobbee, M Prinssen, M R H M van Sambeek, E L G Verhoeven, A F Baas, M G Hunink, J M van Engelshoven, M J H M Jacobs, B A J M de Mol, J H van Bockel, R Balm, J Reekers, X Tielbeek, E L G Verhoeven, W Wisselink, N Boekema, L M Heuveling, I Sikking, M Prinssen, R Balm, J D Blankensteijn, J Buth, P W M Cuypers, M R H M van Sambeek, E L G Verhoeven, J L de Bruin, A F Baas, J D Blankensteijn, M Prinssen, J Buth, A V Tielbeek, J D Blankensteijn, R Balm, J A Reekers, M R H M van Sambeek, P Pattynama, E L G Verhoeven, T Prins, A C van der Ham, J J I M van der Velden, S M M van Sterkenburg, G B ten Haken, C M A Bruijninckx, H van Overhagen, R P Tutein Nolthenius, T R Hendriksz, J A W Teijink, H F Odink, A A E A de Smet, D Vroegindeweij, Jeroen Bosch, R M M van Loenhout, M J Rutten, J F Hamming, L E H Lampmann, M H M Bender, H Pasmans, A C Vahl, C de Vries, A J C Mackaay, L M C van Dortmont, A J van der Vliet, L J Schultze Kool, J H B Boomsma, H R van Dop, J C A de Mol van Otterloo, T P W de Rooij, T M Smits, E N Yilmaz, W Wisselink, F G van den Berg, M J T Visser, E van der Linden, G W H Schurink, M de Haan, H J Smeets, P Stabel, F van Elst, J Poniewierski, F E G Vermassen
Abstract
Background: The relationship between numerous risk factors and perioperative mortality after cardiovascular surgery has been studied extensively. While improved perioperative survival and fewer cardiovascular events have been related to statin therapy, its effect on long-term survival after aneurysm repair remains to be elucidated. The aim of this study is to determine the effect of statin therapy on long-term survival after open and endovascular aneurysm repair and to identify other cardiovascular and patient-related risk factors in this respect.
Methods: A post-hoc analysis of a randomized trial comparing open and endovascular abdominal aortic aneurysm repair was performed. In this multicenter trial, 351 patients were randomly assigned to undergo either open abdominal aortic aneurysm repair or endovascular repair. Patients who were on lipid-lowering medication at their inclusion in the trial (n = 135) were compared with those who were not (n = 216).
Results: During 6 years of follow-up, 118 (33.6%) patients died after randomization. Statin therapy, baseline characteristics, Society for Vascular Surgery/International Society for Cardiovascular Surgery risk factors, aneurysm size, reinterventions, antiplatelet or anticoagulant agents, and β-blockers were used to identify prognostic factors influencing survival. After identification of significant factors in a Kaplan-Meier analysis, a multivariable Cox regression analysis was applied. Statin therapy at inclusion in the trial was independently associated with better overall survival after open or endovascular aneurysm repair (hazard ratio [HR], 0.5; 95% confidence interval [CI], 0.3-0.8; P = .004). Statins were especially associated with fewer cardiovascular deaths (HR, 0.4; 95% CI, 0.2-0.9; P = .025). Several risk factors were associated with poor survival after open and endovascular aneurysm repair: age >70 (HR, 3.4; 95% CI, 2.2-5.0; P < .001), a history of cardiac disease at baseline (HR, 1.9; 95% CI, 1.3-2.8; P = .001), and moderate/severe tobacco use (HR, 1.7; 95% CI, 1.2-2.5; P = .004). Gender, aneurysm size, the need for reintervention, pulmonary disease, renal disease, carotid disease, hypertension, diabetes mellitus, antiplatelet or anticoagulant agents, and β-blockers were not significantly associated with impaired long-term survival (P > .05).
Conclusions: Despite the limitations of a post-hoc analysis of a prospectively maintained trial, we conclude that statin therapy at the beginning of the trial is independently associated with improved long-term survival after open or endovascular aneurysm repair, while age above 70 years, a history of cardiovascular disease, and tobacco use are associated with decreased long-term survival.
Trial registration: ClinicalTrials.gov NCT00421330.
Copyright © 2014 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.
Source: PubMed