Future Directions for Dementia Risk Reduction and Prevention Research: An International Research Network on Dementia Prevention Consensus

Kaarin J Anstey, Ruth Peters, Lidan Zheng, Deborah E Barnes, Carol Brayne, Henry Brodaty, John Chalmers, Linda Clare, Roger A Dixon, Hiroko Dodge, Nicola T Lautenschlager, Laura E Middleton, Chengxuan Qiu, Glenn Rees, Suzana Shahar, Kristine Yaffe, Kaarin J Anstey, Ruth Peters, Lidan Zheng, Deborah E Barnes, Carol Brayne, Henry Brodaty, John Chalmers, Linda Clare, Roger A Dixon, Hiroko Dodge, Nicola T Lautenschlager, Laura E Middleton, Chengxuan Qiu, Glenn Rees, Suzana Shahar, Kristine Yaffe

Abstract

In the past decade a large body of evidence has accumulated on risk factors for dementia, primarily from Europe and North America. Drawing on recent integrative reviews and a consensus workshop, the International Research Network on Dementia Prevention developed a consensus statement on priorities for future research. Significant gaps in geographical location, representativeness, diversity, duration, mechanisms, and research on combinations of risk factors were identified. Future research to inform dementia risk reduction should fill gaps in the evidence base, take a life-course, multi-domain approach, and inform population health approaches that improve the brain-health of whole communities.

Keywords: Multi-domain; primary prevention; risk factor; risk reduction.

Conflict of interest statement

Authors’ disclosures available online (https://www.j-alz.com/manuscript-disclosures/20-0674r1).

Figures

Fig. 1
Fig. 1
Schematic Birdseye View of the Current Landscape of Evidence for Dementia Risk Reduction Research. Note. This heatmap is indicative of the evidence that is currently available from systematic reviews and meta-analyses of dementia risk reduction research. Evidence was collated from a number of large-scale reviews [17–20] and influenced by [13–16, 46, 47].

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Source: PubMed

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