Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study

Matthieu Schmidt, David Hajage, Guillaume Lebreton, Antoine Monsel, Guillaume Voiriot, David Levy, Elodie Baron, Alexandra Beurton, Juliette Chommeloux, Paris Meng, Safaa Nemlaghi, Pierre Bay, Pascal Leprince, Alexandre Demoule, Bertrand Guidet, Jean Michel Constantin, Muriel Fartoukh, Martin Dres, Alain Combes, Groupe de Recherche Clinique en REanimation et Soins intensifs du Patient en Insuffisance Respiratoire aiguE (GRC-RESPIRE) Sorbonne Université, Paris-Sorbonne ECMO-COVID investigators, Charles-Edouard Luyt, Guillaume Hekimian, Nicolas Brechot, Marc Pineton de Chambrun, Cyrielle Desnos, Jeremy Arzoine, Emmanuelle Guerin, Thibaut Schoell, Pierre Demondion, Charles Juvin, Nathalie Nardonne, Sofica Marin, Cossimo D'Alessandro, Bao-Long Nguyen, Cyril Quemeneur, Arthur James, Mona Assefi, Victoria Lepere, Guillaume Savary, Aude Gibelin, Matthieu Turpin, Alexandre Elabbadi, Enora Berti, Corinne Vezinet, Harold Bonvallot, Pierre-Romain Delmotte, Martin De Sarcus, Charlotte Du Fayet De La Tour, Samia Abbas, Eric Maury, Jean-Luc Baudel, Jean-Remi Lavillegrand, Hafid Ait Oufella, Abdelmalek Abdelkrim, Thomas Urbina, Sara Virolle, Robin Deleris, Vincent Bonny, Julien Le Marec, Julien Mayaux, Elise Morawiec, Matthieu Schmidt, David Hajage, Guillaume Lebreton, Antoine Monsel, Guillaume Voiriot, David Levy, Elodie Baron, Alexandra Beurton, Juliette Chommeloux, Paris Meng, Safaa Nemlaghi, Pierre Bay, Pascal Leprince, Alexandre Demoule, Bertrand Guidet, Jean Michel Constantin, Muriel Fartoukh, Martin Dres, Alain Combes, Groupe de Recherche Clinique en REanimation et Soins intensifs du Patient en Insuffisance Respiratoire aiguE (GRC-RESPIRE) Sorbonne Université, Paris-Sorbonne ECMO-COVID investigators, Charles-Edouard Luyt, Guillaume Hekimian, Nicolas Brechot, Marc Pineton de Chambrun, Cyrielle Desnos, Jeremy Arzoine, Emmanuelle Guerin, Thibaut Schoell, Pierre Demondion, Charles Juvin, Nathalie Nardonne, Sofica Marin, Cossimo D'Alessandro, Bao-Long Nguyen, Cyril Quemeneur, Arthur James, Mona Assefi, Victoria Lepere, Guillaume Savary, Aude Gibelin, Matthieu Turpin, Alexandre Elabbadi, Enora Berti, Corinne Vezinet, Harold Bonvallot, Pierre-Romain Delmotte, Martin De Sarcus, Charlotte Du Fayet De La Tour, Samia Abbas, Eric Maury, Jean-Luc Baudel, Jean-Remi Lavillegrand, Hafid Ait Oufella, Abdelmalek Abdelkrim, Thomas Urbina, Sara Virolle, Robin Deleris, Vincent Bonny, Julien Le Marec, Julien Mayaux, Elise Morawiec

Abstract

Background: Patients with COVID-19 who develop severe acute respiratory distress syndrome (ARDS) can have symptoms that rapidly evolve to profound hypoxaemia and death. The efficacy of extracorporeal membrane oxygenation (ECMO) for patients with severe ARDS in the context of COVID-19 is unclear. We aimed to establish the clinical characteristics and outcomes of patients with respiratory failure and COVID-19 treated with ECMO.

Methods: This retrospective cohort study was done in the Paris-Sorbonne University Hospital Network, comprising five intensive care units (ICUs) and included patients who received ECMO for COVID-19 associated ARDS. Patient demographics and daily pre-ECMO and on-ECMO data and outcomes were collected. Possible outcomes over time were categorised into four different states (states 1-4): on ECMO, in the ICU and weaned off ECMO, alive and out of ICU, or death. Daily probabilities of occupation in each state and of transitions between these states until day 90 post-ECMO onset were estimated with use of a multi-state Cox model stratified for each possible transition. Follow-up was right-censored on July 10, 2020.

Findings: From March 8 to May 2, 2020, 492 patients with COVID-19 were treated in our ICUs. Complete day-60 follow-up was available for 83 patients (median age 49 [IQR 41-56] years and 61 [73%] men) who received ECMO. Pre-ECMO, 78 (94%) patients had been prone-positioned; their median driving pressure was 18 (IQR 16-21) cm H2O and PaO2/FiO2 was 60 (54-68) mm Hg. At 60 days post-ECMO initiation, the estimated probabilities of occupation in each state were 6% (95% CI 3-14) for state 1, 18% (11-28) for state 2, 45% (35-56) for state 3, and 31% (22-42) for state 4. 35 (42%) patients had major bleeding and four (5%) had a haemorrhagic stroke. 30 patients died.

Interpretation: The estimated 60-day survival of ECMO-rescued patients with COVID-19 was similar to that of studies published in the past 2 years on ECMO for severe ARDS. If another COVID-19 outbreak occurs, ECMO should be considered for patients developing refractory respiratory failure despite optimised care.

Funding: None.

Copyright © 2020 Elsevier Ltd. All rights reserved.

Figures

Figure 1
Figure 1
Study profile Study profile for patients included in this study, and their outcomes at July 10, 2020. ICU=intensive care unit. ECMO=extracorporeal membrane oxygenation.
Figure 2
Figure 2
Stacked probability plot for the multi-state model The plot illustrates the actual state occupation probabilities of being in each endpoint state—on ECMO, in ICU and weaned off ECMO, alive and out of ICU, or died—over the 90 days following ECMO implantation. The respective probabilities and mean lengths of stay (with 95% CI) in each of these four states are reported in table 4. See the appendix (p 15) for all possible transition probabilities from one state to another over time. ECMO=extracorporeal membrane oxygenation. ICU=intensive care unit.

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Source: PubMed

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