Analysis of coronary angiography related psychophysiological responses

Şükrü Okkesim, Sadik Kara, Mehmet G Kaya, Musa H Asyali, Şükrü Okkesim, Sadik Kara, Mehmet G Kaya, Musa H Asyali

Abstract

Background: Coronary angiography is an important tool in diagnosis of cardiovascular diseases. However, it is the administration is relatively stressful and emotionally traumatic for the subjects. The aim of this study is to evaluate psychophysiological responses induced by the coronary angiography instead of subjective methods such as a questionnaire. We have also evaluated the influence of the tranquilizer on the psychophysiological responses.

Methods: Electrocardiography (ECG), Blood Volume Pulse (BVP), and Galvanic Skin Response (GSR) of 34 patients who underwent coronary angiography operation were recorded. Recordings were done at three phases: "1 hour before," "during," and "1 hour after" the coronary angiography test. Total of 5 features obtained from the physiological signals were compared across these three phases. Sixteen of the patients were administered 5 mg of a tranquilizer (Diazepam) before the operation and remaining 18 were not.

Results: Our results indicate that there is a strong correlation between features (LF/HF, Bk, DN1/DN2, skin conductance level and seg_mean) in terms of reflecting psychophysiological responses. However only DN1/DN2 feature has statistically significant differences between angiography phases (for diazepam: p = 0.0201, for non_diazepam p = 0.0224). We also note that there are statistically significant differences between the diazepam and non-diazepam groups for seg_mean features in "before", "during" and "after" phases (p = 0.0156, 0.0282, and 0.0443, respectively).

Conclusions: The most intense sympathetic activity is observed in the "during" angiography phase for both of the groups. The obtained features can be used in some clinical studies where generation of the customized/individual diagnoses styles and quantitative evaluation of psychophysiological responses is necessary.

Figures

Figure 1
Figure 1
The raw ECG, BVP and GSR signals recorded from a patient in the non-diazepam group during the "before angiography" phase.
Figure 2
Figure 2
Power spectral density analysis of HRV signal of a patient in the non-diazepam group "during the angiography" phase.
Figure 3
Figure 3
Local maximum and minimum points in the BVP signal and dicrotic notches.
Figure 4
Figure 4
Power spectral density analysis of a patient's BVP signal in the non-diazepam group "during the angiography" phase. (The duration of the signal and sampling frequency was respectively 467,407 second and 1000Hz).
Figure 5
Figure 5
Over-all LF/HF ratios (Mean ± SEM) across different angiography phases.
Figure 6
Figure 6
Over-all median Bk values (Mean ± SEM) across different angiography phases.
Figure 7
Figure 7
Over-all DN1 values (Mean ± SEM) across different angiography phases.
Figure 8
Figure 8
Over-all DN2 values (Mean ± SEM) across different angiography phases.
Figure 9
Figure 9
Over-all DN1/DN2 values (Mean ± SEM) across different angiography phases.
Figure 10
Figure 10
Over-all mean GSR values (Mean ± SEM) across different angiography phases.
Figure 11
Figure 11
Over-all median seg_mean values (Mean ± SEM) across different angiography phases.

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Source: PubMed

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