Variation of interstitial glucose measurements assessed by continuous glucose monitors in healthy, nondiabetic individuals
Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group, Larry A Fox, Roy W Beck, Dongyuan Xing, H Peter Chase, Lisa K Gilliam, Irl Hirsch, Craig Kollman, Lori Laffel, Joyce Lee, Katrina J Ruedy, William V Tamborlane, Michael Tansey, Darrell M Wilson, Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group, Larry A Fox, Roy W Beck, Dongyuan Xing, H Peter Chase, Lisa K Gilliam, Irl Hirsch, Craig Kollman, Lori Laffel, Joyce Lee, Katrina J Ruedy, William V Tamborlane, Michael Tansey, Darrell M Wilson
Abstract
Objective: To characterize glucose levels during daily living using continuous glucose monitors (CGMs) in nondiabetic individuals.
Research design and methods: Seventy-four healthy children, adolescents, and adults aged 9-65 years with normal glucose tolerance used a blinded CGM device for 3 to 7 days.
Results: Sensor glucose concentrations were 71-120 mg/dl for 91% of the day. Sensor values were <or=60 or >140 mg/dl for only 0.2% and 0.4% of the day, respectively. Sensor glucose concentrations were slightly higher in children than adults (P = 0.009) and were slightly lower during the night than day (95 vs. 99 mg/dl, P < 0.001).
Conclusions: Glucose values <or=60 and >140 mg/dl, measured with CGM, are uncommon in healthy, nondiabetic individuals. CGM may be useful to evaluate glucose tolerance in nondiabetic individuals over time. Furthermore, these data provide a basis for comparison for studies that use CGM to assess glucose control in subjects with diabetes.
References
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Source: PubMed