Characteristics and comparison between diabetes mellitus and non-diabetes mellitus among chronic kidney disease patients: A cross-sectional study of the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

Jun-Jun Zhang, Liu Yang, Jun-Wen Huang, Yu-Jie Liu, Jin-Wei Wang, Lu-Xia Zhang, Ming-Hui Zhao, Zhang-Suo Liu, Jun-Jun Zhang, Liu Yang, Jun-Wen Huang, Yu-Jie Liu, Jin-Wei Wang, Lu-Xia Zhang, Ming-Hui Zhao, Zhang-Suo Liu

Abstract

Although the prevalence of chronic kidney disease (CKD) and diabetes mellitus (DM) is increasing globally, information on Chinese CKD patients with DM is lacking. A total of 3499 pre-dialysis CKD patients from across China were enrolled in the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) between November 2011 and April 2016. We divided the C-STRIDE patients into CKD with DM and CKD without DM groups and compared their clinical, demographic, and laboratory data in this cross-sectional study. CKD patients with DM were older, had a higher male-to-female ratio, and had more complications than CKD patients without DM. Age, smoking, and 24-h urinary protein levels were associated with co-occurrence of CKD and DM. Less than 50% of patients in either group took antilipemic, cardiovascular, cerebrovascular, or anti-anemic drugs. In addition, only 18.38% of CKD patients with DM had undergone a renal biopsy, and diabetic nephropathy was confirmed in 35.4% of them. Our findings suggest that several types of medication and renal biopsies should be used more frequently in the treatment of Chinese CKD patients with DM.

Keywords: chronic kidney disease; clinical traits; diabetes mellitus; diabetic nephropathy; medication.

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
(A) Prevalence of complications in chronic kidney disease (CKD) patients with and without diabetes mellitus (DM) (**P < 0.001). (B) Treatments administered for complications in chronic kidney disease (CKD) patients with and without diabetes mellitus (DM) (**P < 0.001).

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Source: PubMed

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