Local anesthetics: a century of progress

J A Yagiela, J A Yagiela

Abstract

One century after the clinical introduction of cocaine, local anesthesia remains the most important method of pain control in dentistry. Many local anesthetics have been marketed since 1884, and it is likely that attempts to produce drugs that enhance anesthetic efficacy, reduce systemic and local toxicity, and increase nociceptive selectivity, will continue. In addition, new methods of drug administration have been and will be developed to achieve these goals. Of fundamental importance to such improvements are investigations into the pharmacology of drugs with local anesthetic activity and anatomical and physiologic studies pertaining to the reasons why local anesthetics sometimes fail to achieve desired results. This paper reviews recent advances in our understanding of these drugs and their clinical use.

References

    1. J Gen Physiol. 1966 May;49(5):1043-63
    1. J Dent Res. 1964 Nov-Dec;43:1228-49
    1. J Am Dent Assoc. 1969 Jan;78(1):85-90
    1. Br Dent J. 1969 Jun 17;126(12):557-62
    1. Aust Dent J. 1969 Dec;14(6):377-81
    1. J Am Dent Assoc. 1971 Jul;83(1):149-54
    1. Neurosci Res (N Y). 1971;4:65-99
    1. Ann Intern Med. 1973 Apr;78(4):499-508
    1. J Gen Physiol. 1973 Jul;62(1):37-57
    1. Oral Surg Oral Med Oral Pathol. 1973 Sep;36(3):321-8
    1. J S C Med Assoc. 1974 Nov;70(11):359-65
    1. Acta Anaesthesiol Scand. 1974;18(2):79-87
    1. J Pharmacol Exp Ther. 1976 May;197(2):426-38
    1. Anesth Analg. 1976 Jul-Aug;55(4):568-73
    1. Oral Surg Oral Med Oral Pathol. 1976 Sep;42(3):301-7
    1. Anesthesiology. 1977 Jan;46(1):5-10
    1. Br Dent J. 1977 Feb 15;142(4):129-30
    1. Int J Oral Surg. 1977 Feb;6(1):51-9
    1. J Gen Physiol. 1977 Apr;69(4):497-515
    1. J Am Dent Assoc. 1977 Jun;94(6):1142-5
    1. Br J Oral Surg. 1977 Jul;15(1):83-7
    1. Biophys J. 1977 Dec;20(3):343-68
    1. J Gen Physiol. 1978 Feb;71(2):223-5
    1. Acta Anaesthesiol Scand. 1978;22(6):601-8
    1. Anesth Analg. 1979 Mar-Apr;58(2):99-103
    1. Anesth Prog. 1978 May-Jun;25(3):87-91
    1. J Biol Chem. 1979 May 25;254(10):4119-25
    1. Anesth Prog. 1979 Jan-Feb;26(1):20-3
    1. Brain Res. 1980 May 12;189(2):561-4
    1. Acta Anaesthesiol Scand. 1979 Dec;23(6):567-74
    1. Biochem J. 1980 Jul 15;190(1):131-7
    1. Can J Biochem. 1980 Oct;58(10):986-95
    1. Anesthesiology. 1981 Mar;54(3):182-6
    1. Anesthesiology. 1981 Apr;54(4):265-9
    1. Anesth Analg. 1981 Jun;60(6):395-400
    1. J Gen Physiol. 1981 Feb;77(2):137-53
    1. Eur Heart J. 1981 Jun;2(3):235-7
    1. Clin Pharmacol Ther. 1982 Jan;31(1):62-7
    1. Ann Intern Med. 1982 May;96(5):592-4
    1. Exp Neurol. 1982 Jun;76(3):547-52
    1. Acta Anaesthesiol Scand. 1982 Jun;26(3):242-9
    1. Can Anaesth Soc J. 1982 Sep;29(5):489-91
    1. Anesth Analg. 1983 Jan;62(1):109-11
    1. Clin Pharmacol Ther. 1983 Feb;33(2):133-8
    1. Acta Anaesthesiol Scand. 1982 Dec;26(6):596-8
    1. Ann Intern Med. 1983 Feb;98(2):174-7
    1. Indian J Exp Biol. 1982 Apr;20(4):330-3
    1. J Am Dent Assoc. 1983 Aug;107(2):239-45
    1. J Am Dent Assoc. 1983 Oct;107(4):616-8
    1. J Am Dent Assoc. 1983 Oct;107(4):623-30
    1. J Am Dent Assoc. 1983 Dec;107(6):953-6
    1. Anesth Analg. 1984 Jan;63(1):1-7
    1. Anesth Prog. 1984 Jul-Aug;31(4):159-64
    1. Anesth Prog. 1985 Mar-Apr;32(2):57-61
    1. J Oral Surg Anesth Hosp Dent Serv. 1963 May;21:215-9
    1. J Pharmacol Exp Ther. 1963 May;140:138-48
    1. J Gen Physiol. 1964 Nov;48:357-74
    1. Oral Surg Oral Med Oral Pathol. 1968 Sep;26(3):304-11

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