Does Low-Magnitude High-Frequency Vibration (LMHFV) Worth for Clinical Trial on Dental Implant? A Systematic Review and Meta-Analysis on Animal Studies

Xinjian Ye, Ying Gu, Yijing Bai, Siqi Xia, Yujia Zhang, Yuwei Lou, Yuchi Zhu, Yuwei Dai, James Kit-Hon Tsoi, Shuhua Wang, Xinjian Ye, Ying Gu, Yijing Bai, Siqi Xia, Yujia Zhang, Yuwei Lou, Yuchi Zhu, Yuwei Dai, James Kit-Hon Tsoi, Shuhua Wang

Abstract

Being as a non-pharmacological medical intervention, low-magnitude high-frequency vibration (LMHFV) has shown a positive effect on bone induction and remodeling for various muscle diseases in animal studies, among which dental implants osteointegration were reported to be improved as well. However, whether LMHFV can be clinically used in dental implant is still unknown. In this study, efficacy, parameters and side effects of LMHFV were analyzed via data before 15th July 2020, collecting from MEDLINE/PubMed, Embase, Ovid and Cochrane Library databases. In the screened 1,742 abstracts and 45 articles, 15 animal studies involving 972 implants were included. SYRCLE's tool was performed to assess the possible risk of bias for each study. The GRADE approach was applied to evaluate the quality of evidence. Random effects meta-analysis detected statistically significant in total BIC (P < 0.0001) and BV/TV (P = 0.001) upon loading LMHFV on implants. To conclude, LMHFV played an active role on BIC and BV/TV data according to the GRADE analysis results (medium and low quality of evidence). This might illustrate LMHFV to be a worthy way in improving osseointegration clinically, especially for osteoporosis. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO, identifier: NCT02612389.

Keywords: dental implant; low-magnitude high-frequency vibration; osseointegration; osteoporosis; systematic review and meta-analysis.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2021 Ye, Gu, Bai, Xia, Zhang, Lou, Zhu, Dai, Tsoi and Wang.

Figures

Figure 1
Figure 1
PRISMA flowchart of the screening process.
Figure 2
Figure 2
Bubble chart of frequencies (Hz), magnitudes (g/μm), and duration (min) of vibration treatment used in the studies. Green bubbles indicate more than two-thirds positive measurements, among which two test data were statistically significant (P < 0.05); Yellow bubbles indicate more than half positive measurements; Red bubbles indicate more than half negative measurements. Area of circle represents LMHFV loading duration. aAn average of the composite vibration; bconverted from other units. (A) OVX-WBV group; (B) non-OVX-WBV group; (C) non-OVX-DLV group.
Figure 3
Figure 3
Meta-analysis. BIC Standardized mean differences of LMHFV treated compared to sham or untreated animals.
Figure 4
Figure 4
Meta-analysis. BV/TV Standardized mean differences of LMHFV treated compared to sham or untreated animals.
Figure 5
Figure 5
Results of SYRCLE's RoB tool in included studies. (A) Representative summary table for the risk of bias assessment; (B) Representative summary for risk of bias analysis across studies.

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