The efficacy and safety of Endostar combined with chemoradiotherapy for patients with advanced, locally recurrent nasopharyngeal carcinoma

Ying Guan, Anchuan Li, Weiwei Xiao, Shuai Liu, Binbin Chen, Taixiang Lu, Chong Zhao, Fei Han, Ying Guan, Anchuan Li, Weiwei Xiao, Shuai Liu, Binbin Chen, Taixiang Lu, Chong Zhao, Fei Han

Abstract

Purpose: To evaluate the short-term efficacy and safety of recombinant human endostatin (Endostar) combined with chemoradiotherapy for the treatment of advanced, locally recurrent nasopharyngeal carcinoma (NPC).

Materials and methods: Between March 2010 and October 2013, a total of 22 patients with stage rIII-IVb locally recurrent NPC underwent salvage radiotherapy with Endostar in Sun Yat-Sen University Cancer Center. Intensity-modulated radiotherapy (IMRT) was delivered. Platinum-based chemotherapy was used in a neoadjuvant protocol. Endostar was continuously administered intravenously (105 mg/m2) for 14 days (Days 1-14) from the first day of treatment during a 21-day cycle. Tumor response and treatment toxicities were observed.

Results: Until January 2014, the median follow-up time was 13 months (range, 4-41 months). All patients completed the planned radiotherapy. A complete response was achieved in 20 patients, and a partial response was achieved in 2 patients. The incidence of grade 3-5 late radiation injury in this study was 50% (11/22) and that of nasopharyngeal mucosal necrosis was 31.8% (7/22).

Conclusions: Endostar combined with chemoradiotherapy may be effective in decreasing both the incidence of nasopharyngeal mucosal necrosis. Studies with a larger sample size and longer follow-up are warranted.

Keywords: Endostar; chemotherapy; intensity-modulated radiotherapy; nasopharyngeal carcinoma; recurrence.

Conflict of interest statement

CONFLICTS OF INTEREST

The authors have declared no competing interests.

Figures

Figure 1. Nasopharyngeal images of recurrent nasopharyngeal…
Figure 1. Nasopharyngeal images of recurrent nasopharyngeal carcinoma patients
Patients with IMRT alone: A1. Before re-irradiation of patient A, A2. End of re-irradiation of patient A, B1. End of re-irradiation of patient B, B2. 2 years after re-irradiation of patient B; Patients with Endostar® + IMRT, C1. End of re-irradiation of patient C, C2. 1 month after re-irradiation of patient C, D1. End of re-irradiation of patient D, D2. 18 months after re-irradiation of patient D. IMRT, Intensity-modulated radiotherapy.

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Source: PubMed

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