Paraoxonase 1 Activity, Lipid Profile, and Atherogenic Indexes Status in Coronary Heart Disease

Abstract

Background: Dyslipidemia is considered an independent risk factor for coronary heart disease (CHD). In the present study, we examined lipid profiles and paraoxonase 1 (PON1) activity and atherogenic indexes status and the relationship of PON1 activity by high-density lipoprotein (HDL) and atherogenic indexes in CHD patients and healthy people.

Methods: The aim of the study was to compare PON1, lipid profiles, and atherogenic indexes in CHD patients and healthy people as controls. This study enrolled 50 CHD patients and 50 matched healthy controls. Serum activities of PON1 and levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), and atherogenic indexes were analyzed. Data were analyzed by unpaired Student's t tests. Coefficients of correlation were calculated using Pearson's correlation analysis.

Results: Levels of TG, TC, LDL, VLDL, FBG, and atherogenic indexes, atherogenic coefficients, and cardiac risk ratios were significantly greater in CHD patients than in controls. Paraoxonase 1 activity and HDL-C levels were significantly less in CHD patients than in controls. Also, PON1 activity correlated positively with HDLC and negatively with atherogenic coefficient, and cardiac risk ratios 1 and 2 in CHD patients.

Conclusion: This study showed that CHD is associated with high lipid levels and atherogenic indexes, and low PON1 activity and HDL-C concentrations. Coronary heart disease is a pernicious disease requiring prolonged medical management and hypolipidemic drugs.

Keywords: Atherogenic index; Coronary heart disease; Lipid profile; Paraoxonase 1 activity.

Figures

Fig. 1

Correlation between serum PON1 activity and HDL-C levels. (r = 0.261, p = 0.045).

Fig. 2

Correlation between serum PON1 activity and AC levels (Atherogenic Coefficient (TC-HDLC)/HDL-C)). (r = -0.083, p = 0.303).

Fig. 3

Correlation between serum PON1 activity and CRR1 levels (Cardiac Risk Ratio 1 (TC/HDL-C)). (r = -0.071, p = 0.33).

Fig. 4

Correlation between serum PON1 activity and CRR2 levels (Cardiac Risk Ratio 2 (LDL/HDL-C)). (r = -0.045, p = 0.39).