Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study
Maxime J M van der Valk, Denise E Hilling, Esther Bastiaannet, Elma Meershoek-Klein Kranenbarg, Geerard L Beets, Nuno L Figueiredo, Angelita Habr-Gama, Rodrigo O Perez, Andrew G Renehan, Cornelis J H van de Velde, IWWD Consortium, Madeleine Ahlberg, Ane Appelt, Oktar Asoglu, Maria-Theresa Bär, Rita Barroca, Regina G H Beets-Tan, Eric H J Belgers, Robbert J I Bosker, Stéphanie O Breukink, Krysztof Bujko, Carlos Carvalho, Christopher Cunningham, Ben Creavin, André D'Hoore, Jean-Pierre Gérard, Simon Gollins, Christiaan Hoff, Fabian A Holman, Britt J P Hupkens, Soledad Iseas, Anders Jakobsen, Amir Keshvari, Sietze A Koopal, Miranda Kusters, Melanie Langheinrich, Jeroen W A Leijtens, Monique Maas, Lee Malcomson, Zamam Z Mamedli, Anna Martling, Klaus E Matzel, Jarno Melenhorst, María L Morici, Sthela M Murad-Regadas, Sarah T O'Dwyer, Koen C M J Peeters, Isadora Rosa, Gustavo Rossi, Harm J T Rutten, Fernando Sanchez Loria, Marit E van der Sande, Guilherme P São Julião, Mark Saunders, Arthur Sun Myint, Hedwig van der Sluis, Renaud Schiappa, Nigel Scott, Jan H M B Stoot, A Koen Talsma, Isabelle Terrasson, Handan Tokmak, Carlos A Vaccaro, Alexander L Vahrmeijer, Daria K Wasowicz, Henderik L Westreenen, Des C Winter, Albert M Wolthuis, David D E Zimmerman, Maxime J M van der Valk, Denise E Hilling, Esther Bastiaannet, Elma Meershoek-Klein Kranenbarg, Geerard L Beets, Nuno L Figueiredo, Angelita Habr-Gama, Rodrigo O Perez, Andrew G Renehan, Cornelis J H van de Velde, IWWD Consortium, Madeleine Ahlberg, Ane Appelt, Oktar Asoglu, Maria-Theresa Bär, Rita Barroca, Regina G H Beets-Tan, Eric H J Belgers, Robbert J I Bosker, Stéphanie O Breukink, Krysztof Bujko, Carlos Carvalho, Christopher Cunningham, Ben Creavin, André D'Hoore, Jean-Pierre Gérard, Simon Gollins, Christiaan Hoff, Fabian A Holman, Britt J P Hupkens, Soledad Iseas, Anders Jakobsen, Amir Keshvari, Sietze A Koopal, Miranda Kusters, Melanie Langheinrich, Jeroen W A Leijtens, Monique Maas, Lee Malcomson, Zamam Z Mamedli, Anna Martling, Klaus E Matzel, Jarno Melenhorst, María L Morici, Sthela M Murad-Regadas, Sarah T O'Dwyer, Koen C M J Peeters, Isadora Rosa, Gustavo Rossi, Harm J T Rutten, Fernando Sanchez Loria, Marit E van der Sande, Guilherme P São Julião, Mark Saunders, Arthur Sun Myint, Hedwig van der Sluis, Renaud Schiappa, Nigel Scott, Jan H M B Stoot, A Koen Talsma, Isabelle Terrasson, Handan Tokmak, Carlos A Vaccaro, Alexander L Vahrmeijer, Daria K Wasowicz, Henderik L Westreenen, Des C Winter, Albert M Wolthuis, David D E Zimmerman
Abstract
Background: The strategy of watch and wait (W&W) in patients with rectal cancer who achieve a complete clinical response (cCR) after neoadjuvant therapy is new and offers an opportunity for patients to avoid major resection surgery. However, evidence is based on small-to-moderate sized series from specialist centres. The International Watch & Wait Database (IWWD) aims to describe the outcome of the W&W strategy in a large-scale registry of pooled individual patient data. We report the results of a descriptive analysis after inclusion of more than 1000 patients in the registry.
Methods: Participating centres entered data in the registry through an online, highly secured, and encrypted research data server. Data included baseline characteristics, neoadjuvant therapy, imaging protocols, incidence of local regrowth and distant metastasis, and survival status. All patients with rectal cancer in whom the standard of care (total mesorectal excision surgery) was omitted after neoadjuvant therapy were eligible to be included in the IWWD. For the present analysis, we only selected patients with no signs of residual tumour at reassessment (a cCR). We analysed the proportion of patients with local regrowth, proportion of patients with distant metastases, 5-year overall survival, and 5-year disease-specific survival.
Findings: Between April 14, 2015, and June 30, 2017, we identified 1009 patients who received neoadjuvant treatment and were managed by W&W in the database from 47 participating institutes (15 countries). We included 880 (87%) patients with a cCR. Median follow-up time was 3·3 years (95% CI 3·1-3·6). The 2-year cumulative incidence of local regrowth was 25·2% (95% CI 22·2-28·5%), 88% of all local regrowth was diagnosed in the first 2 years, and 97% of local regrowth was located in the bowel wall. Distant metastasis were diagnosed in 71 (8%) of 880 patients. 5-year overall survival was 85% (95% CI 80·9-87·7%), and 5-year disease-specific survival was 94% (91-96%).
Interpretation: This dataset has the largest series of patients with rectal cancer treated with a W&W approach, consisting of approximately 50% data from previous cohort series and 50% unpublished data. Local regrowth occurs mostly in the first 2 years and in the bowel wall, emphasising the importance of endoscopic surveillance to ensure the option of deferred curative surgery. Local unsalvageable disease after W&W was rare.
Funding: European Registration of Cancer Care financed by European Society of Surgical Oncology, Champalimaud Foundation Lisbon, Bas Mulder Award granted by the Alpe d'Huzes Foundation and Dutch Cancer Society, and European Research Council Advanced Grant.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Source: PubMed