Intervention to Match Young Black Men and Transwomen Who Have Sex With Men or Transwomen to HIV Testing Options (All About Me): Protocol for a Randomized Controlled Trial

Beryl Koblin, Sabina Hirshfield, Mary Ann Chiasson, Leo Wilton, DaShawn Usher, Vijay Nandi, Donald R Hoover, Victoria Frye, Beryl Koblin, Sabina Hirshfield, Mary Ann Chiasson, Leo Wilton, DaShawn Usher, Vijay Nandi, Donald R Hoover, Victoria Frye

Abstract

Background: HIV testing is a critical component of HIV prevention and care. Interventions to increase HIV testing rates among young black men who have sex with men (MSM) and black transgender women (transwomen) are needed. Personalized recommendations for an individual's optimal HIV testing approach may increase testing.

Objective: This randomized trial tests the hypothesis that a personalized recommendation of an optimal HIV testing approach will increase HIV testing more than standard HIV testing information.

Methods: A randomized trial among 236 young black men and transwomen who have sex with men or transwomen is being conducted. Participants complete a computerized baseline assessment and are randomized to electronically receive a personalized HIV testing recommendation or standard HIV testing information. Follow-up surveys are conducted online at 3 and 6 months after baseline.

Results: The All About Me randomized trial was launched in June 2016. Enrollment is completed and 3-month retention is 92.4% (218/236) and has exceeded study target goals.

Conclusions: The All About Me intervention is an innovative approach to increase HIV testing by providing a personalized recommendation of a person's optimal HIV testing approach. If successful, optimizing this intervention for mobile devices will widen access to large numbers of individuals.

Trial registration: ClinicalTrial.gov NCT02834572; https://ichgcp.net/clinical-trials-registry/NCT02834572 (Archived by WebCite at http://www.webcitation.org/6vLJWOS1B).

Keywords: HIV testing, black men who have sex with men, transgender women, mobile technology, HIV prevention.

Conflict of interest statement

Conflicts of Interest: None declared.

©Beryl Koblin, Sabina Hirshfield, Mary Ann Chiasson, Leo Wilton, DaShawn Usher, Vijay Nandi, Donald R Hoover, Victoria Frye. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 19.12.2017.

Figures

Figure 1
Figure 1
All About Me platform introductory page (persons shown in photographs are models and are not actual study participants).
Figure 2
Figure 2
Still from video describing All About Me trial.
Figure 3
Figure 3
Stills from GIFs describing HIV testing approaches.
Figure 4
Figure 4
Personalized HIV testing approach.
Figure 5
Figure 5
CONSORT flow diagram.

References

    1. Centers for Disease Control and Prevention. HIV Surveillance report 2016 05-Jul-2017; 27 .
    1. Koblin BA, Mayer KH, Eshleman SH, Wang L, Mannheimer S, del Rio C, Shoptaw S, Magnus M, Buchbinder S, Wilton L, Liu T, Cummings V, Piwowar-Manning E, Fields SD, Griffith S, Elharrar V, Wheeler D. Correlates of HIV acquisition in a cohort of Black men who have sex with men in the United States: HIV prevention trials network (HPTN) 061. PLoS One. 2013;8(7):e70413. doi: 10.1371/journal.pone.0070413.
    1. Wejnert C, Hess KL, Rose CE, Balaji A, Smith JC, Paz-Bailey G, NHBS Study Group Age-specific race and ethnicity disparities in HIV infection and awareness among men who have sex with men--20 US cities, 2008-2014. J Infect Dis. 2016 Mar 01;213(5):776–783. doi: 10.1093/infdis/jiv500.
    1. Sullivan PS, Rosenberg ES, Sanchez TH, Kelley CF, Luisi N, Cooper HL, Diclemente RJ, Wingood GM, Frew PM, Salazar LF, Del Rio C, Mulligan MJ, Peterson JL. Explaining racial disparities in HIV incidence in black and white men who have sex with men in Atlanta, GA: a prospective observational cohort study. Ann Epidemiol. 2015 Jun;25(6):445–454. doi: 10.1016/j.annepidem.2015.03.006.
    1. Habarta N, Wang G, Mulatu MS, Larish N. HIV testing by transgender status at Centers for Disease Control and Prevention-funded sites in the United States, Puerto Rico, and US Virgin Islands, 2009-2011. Am J Public Health. 2015 Sep;105(9):1917–1925. doi: 10.2105/AJPH.2015.302659.
    1. Rapues J, Wilson EC, Packer T, Colfax GN, Raymond HF. Correlates of HIV infection among transfemales, San Francisco, 2010: results from a respondent-driven sampling study. Am J Public Health. 2013 Aug;103(8):1485–1492. doi: 10.2105/AJPH.2012.301109.
    1. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, Hakim JG, Kumwenda J, Grinsztejn B, Pilotto JH, Godbole SV, Chariyalertsak S, Santos BR, Mayer KH, Hoffman IF, Eshleman SH, Piwowar-Manning E, Cottle L, Zhang XC, Makhema J, Mills LA, Panchia R, Faesen S, Eron J, Gallant J, Havlir D, Swindells S, Elharrar V, Burns D, Taha TE, Nielsen-Saines K, Celentano DD, Essex M, Hudelson SE, Redd AD, Fleming TR. Antiretroviral therapy for the prevention of HIV-1 transmission. N Engl J Med. 2016 Sep 01;375(9):830–839. doi: 10.1056/NEJMoa1600693.
    1. Branson BM, Handsfield HH, Lampe MA, Janssen RS, Taylor AW, Lyss SB, Clark JE, Centers for Disease Control and Prevention Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings. MMWR Recomm Rep. 2006 Sep 22;55(RR-14):1–17; quiz CE1.
    1. Workowski KA, Bolan GA, Centers for Disease Control and Prevention Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015 Jun 05;64(RR-03):1–137.
    1. Cooley LA, Oster AM, Rose CE, Wejnert C, Le BC, Paz-Bailey G. Increases in HIV testing among men who have sex with men--National HIV Behavioral Surveillance System, 20 U.S. Metropolitan Statistical Areas, 2008 and 2011. PLoS One. 2014;9(9):e104162. doi: 10.1371/journal.pone.0104162.
    1. Hergenrather KC, Emmanuel D, Durant S, Rhodes SD. Enhancing HIV prevention among young men who have sex with men: a systematic review of HIV behavioral interventions for young gay and bisexual men. AIDS Educ Prev. 2016 Jun;28(3):252–271. doi: 10.1521/aeap.2016.28.3.252.
    1. Seth P, Walker T, Hollis N, Figueroa A, Belcher L, Centers for Disease Control and Prevention HIV testing and service delivery among Blacks or African Americans--61 health department jurisdictions, United States, 2013. MMWR Morb Mortal Wkly Rep. 2015 Feb 06;64(4):87–90.
    1. Garnett M, Hirsch-Moverman Y, Franks J, Hayes-Larson E, El-Sadr WM, Mannheimer S. Limited awareness of pre-exposure prophylaxis among black men who have sex with men and transgender women in New York city. AIDS Care. 2017 Aug 09;:1–9. doi: 10.1080/09540121.2017.1363364.
    1. Singh S, Mitsch A, Wu B. HIV Care outcomes among men who have sex with men with diagnosed HIV infection - United States, 2015. MMWR Morb Mortal Wkly Rep. 2017 Sep 22;66(37):969–974. doi: 10.15585/mmwr.mm6637a2. doi: 10.15585/mmwr.mm6637a2.
    1. Habarta N, Boudewyns V, Badal H, Johnston J, Uhrig J, Green D, Ruddle P, Rosenthal J, Stryker JE. CDC'S Testing Makes Us Stronger (TMUS) campaign: was campaign exposure associated with HIV testing behavior among black gay and bisexual men? AIDS Educ Prev. 2017 Jun;29(3):228–240. doi: 10.1521/aeap.2017.29.3.228.
    1. Lorenc T, Marrero-Guillamón I, Aggleton P, Cooper C, Llewellyn A, Lehmann A, Lindsay C. Promoting the uptake of HIV testing among men who have sex with men: systematic review of effectiveness and cost-effectiveness. Sex Transm Infect. 2011 Jun;87(4):272–278. doi: 10.1136/sti.2010.048280.
    1. Zou H, Fairley CK, Guy R, Chen MY. The efficacy of clinic-based interventions aimed at increasing screening for bacterial sexually transmitted infections among men who have sex with men: a systematic review. Sex Transm Dis. 2012 May;39(5):382–387. doi: 10.1097/OLQ.0b013e318248e3ff.
    1. Heijman RL, Stolte IG, Thiesbrummel HF, van Leent E, Coutinho RA, Fennema JS, Prins M. Opting out increases HIV testing in a large sexually transmitted infections outpatient clinic. Sex Transm Infect. 2009 Aug;85(4):249–255. doi: 10.1136/sti.2008.033258.
    1. Dukers-Muijrers NH, Niekamp AM, Vergoossen MM, Hoebe CJ. Effectiveness of an opting-out strategy for HIV testing: evaluation of 4 years of standard HIV testing in a STI clinic. Sex Transm Infect. 2009 Jun;85(3):226–230. doi: 10.1136/sti.2008.033191.
    1. Outlaw AY, Naar-King S, Parsons JT, Green-Jones M, Janisse H, Secord E. Using motivational interviewing in HIV field outreach with young African American men who have sex with men: a randomized clinical trial. Am J Public Health. 2010 Apr 01;100 Suppl 1:S146–S151. doi: 10.2105/AJPH.2009.166991.
    1. Wilton L, Herbst JH, Coury-Doniger P, Painter TM, English G, Alvarez ME, Scahill M, Roberson MA, Lucas B, Johnson WD, Carey JW. Efficacy of an HIV/STI prevention intervention for black men who have sex with men: findings from the Many Men, Many Voices (3MV) project. AIDS Behav. 2009 Jun;13(3):532–544. doi: 10.1007/s10461-009-9529-y.
    1. Ybarra ML, Prescott TL, Philips GL, Bull SS, Parsons JT, Mustanski B. Iteratively developing an mHealth HIV prevention program for sexual minority adolescent men. AIDS Behav. 2015 Aug 4; doi: 10.1007/s10461-015-1146-3.
    1. Mustanski B, Greene GJ, Ryan D, Whitton SW. Feasibility, acceptability, and initial efficacy of an online sexual health promotion program for LGBT youth: the Queer Sex Ed intervention. J Sex Res. 2015;52(2):220–230. doi: 10.1080/00224499.2013.867924.
    1. Mustanski B, Madkins K, Greene GJ, Parsons JT, Johnson BA, Sullivan P, Bass M, Abel R. Internet-based HIV prevention with at-home sexually transmitted infection testing for young men having sex with men: study protocol of a randomized controlled trial of Keep It Up! 2.0. JMIR Res Protoc. 2017 Jan 07;6(1):e1. doi: 10.2196/resprot.5740.
    1. Hightow-Weidman LB, Muessig KE, Pike EC, LeGrand S, Baltierra N, Rucker AJ, Wilson P. : building community through a mobile-optimized, online health promotion intervention. Health Educ Behav. 2015 Aug;42(4):493–499. doi: 10.1177/1090198114562043.
    1. Hightow-Weidman LB, Pike E, Fowler B, Matthews DM, Kibe J, McCoy R, Adimora AA. : feasibility and acceptability of delivering an internet intervention to young Black men who have sex with men. AIDS Care. 2012;24(7):910–920. doi: 10.1080/09540121.2011.647677.
    1. Dowshen N, Lee S, Matty LB, Castillo M, Mollen C. IknowUshould2: feasibility of a youth-driven social media campaign to promote STI and HIV testing among adolescents in Philadelphia. AIDS Behav. 2015 Jun;19 Suppl 2:106–111. doi: 10.1007/s10461-014-0991-9.
    1. Bauermeister JA, Pingel ES, Jadwin-Cakmak L, Harper GW, Horvath K, Weiss G, Dittus P. Acceptability and preliminary efficacy of a tailored online HIV/STI testing intervention for young men who have sex with men: the Get Connected! program. AIDS Behav. 2015 Feb 1; doi: 10.1007/s10461-015-1009-y.
    1. Myers J. HIV Self-testing in New York City. Conference on Retroviruses and Opportunistic Infections; Feb 23-26, 2015; Seattle. 2015.
    1. Huang E, Marlin RW, Young SD, Medline A, Klausner JD. Using Grindr, a smartphone social-networking application, to increase HIV self-testing among black and Latino men who have sex with men in Los Angeles, 2014. AIDS Educ Prev. 2016 Aug;28(4):341–350. doi: 10.1521/aeap.2016.28.4.341.
    1. Merchant RC, Clark MA, Liu T, Romanoff J, Rosenberger JG, Bauermeister J, Mayer KH. Comparison of home-based oral fluid rapid HIV self-testing versus mail-in blood sample collection or medical/community HIV testing by young adult black, Hispanic, and white MSM: results from a randomized trial. AIDS Behav. 2017 May 24; doi: 10.1007/s10461-017-1802-x.
    1. OraQuick. [2016-12-12]. OraQuick in-home HIV test .
    1. Centers for Disease Control and Prevention. 2012. Effective interventions couples HIV testing and counseling .
    1. Karim SS, Karim QA. Antiretroviral prophylaxis: a defining moment in HIV control. Lancet. 2011 Dec 17;378(9809):e23–e25. doi: 10.1016/S0140-6736(11)61136-7.
    1. Sullivan PS, Salazar L, Buchbinder S, Sanchez TH. Estimating the proportion of HIV transmissions from main sex partners among men who have sex with men in five US cities. AIDS. 2009 Jun 1;23(9):1153–1162. doi: 10.1097/QAD.0b013e32832baa34.
    1. Goodreau SM, Carnegie NB, Vittinghoff E, Lama JR, Sanchez J, Grinsztejn B, Koblin BA, Mayer KH, Buchbinder SP. What drives the US and Peruvian HIV epidemics in men who have sex with men (MSM)? PLoS One. 2012;7(11):e50522. doi: 10.1371/journal.pone.0050522.
    1. Patel VV, Masyukova M, Sutton D, Horvath KJ. Social media use and HIV-related risk behaviors in young black and Latino gay and bi men and transgender individuals in New York City: implications for online interventions. J Urban Health. 2016 Apr;93(2):388–399. doi: 10.1007/s11524-016-0025-1.
    1. Koblin BA, Nandi V, Hirshfield S, Chiasson MA, Hoover DR, Wilton L, Usher D, Frye V. Informing the development of a mobile phone HIV testing intervention: intentions to use specific HIV testing approaches among young black transgender women and men who have sex with men. JMIR Public Health Surveill. 2017 Jul 07;3(3):e45. doi: 10.2196/publichealth.7397.
    1. Kroenke K, Spitzer RL, Williams JB. The Patient Health Questionnaire-2: validity of a two-item depression screener. Med Care. 2003 Nov;41(11):1284–1292. doi: 10.1097/01.MLR.0000093487.78664.3C.
    1. Visser MJ, Kershaw T, Makin JD, Forsyth BW. Development of parallel scales to measure HIV-related stigma. AIDS Behav. 2008 Sep;12(5):759–771. doi: 10.1007/s10461-008-9363-7.
    1. Sealed Envelope. [2017-11-29]. .
    1. Garbers S, Meserve A, Kottke M, Hatcher R, Chiasson MA. Tailored health messaging improves contraceptive continuation and adherence: results from a randomized controlled trial. Contraception. 2012 Nov;86(5):536–542. doi: 10.1016/j.contraception.2012.02.005.
    1. Garbers S, Meserve A, Kottke M, Hatcher R, Ventura A, Chiasson MA. Randomized controlled trial of a computer-based module to improve contraceptive method choice. Contraception. 2012 Oct;86(4):383–390. doi: 10.1016/j.contraception.2012.01.013.
    1. Bandura A. Human agency in social cognitive theory. Am Psychol. 1989 Sep;44(9):1175–1184.
    1. Bandura A. Social Learning Theory. Englewood Cliffs, NJ: Prentice-Hall; 1977.
    1. Azjen I. The theory of planned behavior. In: Van Lange PA, Kruglanski AW, Higgens ET, editors. Handbook of Theories of Social Psychology. London: SAGE Publications; 2011. pp. 438–459.
    1. Goffman E. Stigma: Notes of the Management of Spoiled Identity. Englewood Cliffs, NJ: Prentice Hall; 1963.
    1. Abrams D, Hogg M. Social Identity Theory: Constructive and Critical Advances. New York: Prentice-Hall; 1990.
    1. Frye V, Wilton L, Hirshfield S, Chiasson MA, Usher D, Lucy D, McCrossin J, Greene E, Koblin B, All About Me Study Team “Just because it's out there, people aren't going to use it”: HIV self-testing among young, black MSM, and transgender women. AIDS Patient Care STDS. 2015 Nov;29(11):617–624. doi: 10.1089/apc.2015.0100.
    1. . [2017-11-29]. HIV Testing sites & care services locator .
    1. Java Applets for Power and Sample Size. 2017. Jun 06, [2017-11-30]. .

Source: PubMed

赞助者和合作者

医疗条件

药物干预

3
订阅