Kawasaki disease with G6PD deficiency--report of one case and literature review
Chia-Hao Chen, Li-Yan Lin, Kuender D Yang, Kai-Sheng Hsieh, Ho-Chang Kuo, Chia-Hao Chen, Li-Yan Lin, Kuender D Yang, Kai-Sheng Hsieh, Ho-Chang Kuo
Abstract
Kawasaki disease (KD) is a systemic vasculitis primarily affecting children who are younger than 5 years. The most serious complications are coronary artery aneurysms and sequelae of vasculitis with the subsequent development of coronary artery aneurysm. According to the literature, intravenous immunoglobulin (IVIG) plus high-dose aspirin (acetylsalicylic acid) were standard treatment for KD, whereas low-dose aspirin (3-5 mg/kg/day) was used for thrombocytosis in KD via antiplatelet effect. However, aspirin has been reported to have hemolytic potential in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We report a child with G6PD-deficiency who has KD, and review the literature.
Keywords: Aspirin; G6PD deficiency; Kawasaki disease.
Copyright © 2012. Published by Elsevier B.V.
Source: PubMed