Grating visual acuity results in the early treatment for retinopathy of prematurity study

Early Treatment for Retinopathy of Prematurity Cooperative Group, Velma Dobson, Graham E Quinn, C Gail Summers, Robert J Hardy, Betty Tung, William V Good, Ashima Madan, M Bethany Ball, Judith Y Hall, William V Good, William V Good, Judith Gancasz, David Durand, Terri Slagle, Gordon Smith, Michael Shapiro, Nydia Santiago, Rama Bhat, Lawrence Kaufman, Marilyn Miller, David Mittelman, Daniel Neely, Elizabeth A Hynes, David Plager, Charles C Barr, Michelle Bottorff, Greg K Whittington, Peggy H Fishman, Paul J Rychwalski, Robert A Gordon, Deborah S Neff, James G Diamond, William L Gill, Mark W Preslan, Kevin Powdrill, Kelly A Hutcheson, Eric Jones, Scott M Steidl, Joanne Marie Waeltermann, Michael X Repka, Jennifer A Shepard, Pamela Donahue, Susan W Aucott, Mary Louise Z Collins, Maureen M Gilmore, James T Handa, Deborah K VanderVeen, Theresa Mansfield, Brenda MacKinnon, Cynthia H Cole, Anthony Fraioli, David Hunter, O'Ine McCabe, Robert Petersen, Mitchell Brent Strominger, Sarah MacKinnon, Rhiannon Johnson, Mariette Tyedmers, John Baker, Kristi Cumming, Pat Manatrey, Mary P Bedard, Renato Casabar, Antonio Capone, Edward O'Malley, Rajesh Rao, John Roarty, Michael Trese, George Williams, C Gail Summers, Sally Cook, Ann Holleschau, Molly Maxwell, Stephen P Christiansen, David Brasel, Bradley V Davitt, Linda Breuer, Oscar Cruz, William Keenan, Greg Mantych, Gregg Lueder, Sharon Freedman, David Wallace, Lori Hutchins Parkman, Sarah K Jones, Laura Enyedi, Ricki F Goldstein, James D Reynolds, Kristine Ziemann, George P Albert, Steven Awner, Rita Ryan, Pamela Ann Weber, Marc Horowitz, Cherylene Behrendt, Adriann Combs, Natalie Dweck, Richard Koty, Edmund LaGamma, Maury Marmor, John Flynn, Osode Coki, Michael Chiang, Steven Kane, Alfred Krauss, Thomas C Lee, Robert F Lopez, Richard Polin, Dale L Phelps, Cassandra Horihan, Jane Phillips, Gary Markowitz, Walter Merriam, Leon-Paul Noel, Donald Tingley, Matthew Gearinger, Gary L Rogers, Don Bremer, Rae Fellows, Sharon Klamfoth, Brian Arthur, Cybil Bean Cassady, Richard Golden, Mary Lou McGregor, R Michael Siatkowski, Cheryl Harris, Vanessa Yazdanipanah, Reagan H Bradford, Robert E Leonard, Mary Anne McCaffree, David T Wheeler, Nancy Dolphin, Earl A Palmer, Ann Stout, Brian Nichols, David Epley, Graham E Quinn, Jamie G Koh, Marianne Letterio, Soraya Abbasi, Jane C Edmond, Brian J Forbes, Albert M Maguire, Monte D Mills, Eric A Pierce, Terri L Young, Stephanie Davidson, Kenneth Cheng, Janice Kelchner-Cheng, Judith Jones, Robert Bergren, Bernard Doft, Louis Lobes, Karl Olsen, Richard A Saunders, Dilip Purohit, Linda Stevens, Kimberly Lenhart, David K Coats, Michele L Parker, Maria Castanes, Alison Brown, Jane Edmond, Joseph Garcia-Prats, Eric Holz, W Scott Jarriel, Karen Johnson, George Mandy, Evelyn A Paysee, A Melinda Rainey, Paul G Steinkuller, Kimberly G Yen, John P Stokes, Yolanda Trigo, Alice K Gong, W A J van Heuven, Robert Hoffman, Susan Bracken, Deborah Y Harrison, Paul Bernstein, Jerald King, Michael Teske, Maryann Redford, Richard L Mowery, Donald F Everett, William V Good, Michelle Quintos, Robert J Hardy, Betty Tung, Gordon Tsai, Velma Dobson, Deborah D Hargadon, Jeffrey Wood, Graham E Quinn, Erin M Harvey, John Connett, Edward F Donovan, Argye Hillis, Jonathan M Holmes, Joseph M Miller, Carol R Taylor, William V Good, Robert J Hardy, Maryann Redford, William V Good, Robert J Hardy, Velma Dobson, Earl A Palmer, Dale L Phelps, Maryann Redford, W A J van Heuven, Charles Barr, Michael Gaynon, Michael Shapiro, David Wallace, Bradley V Davitt, Rae Fellows, Judith Jones, Kristi Cumming, Deborah S Neff, Jennifer A Shepard, Nancy Dolphin, V Good, Robert J Hardy, Velma Dobson, Earl A Palmer, Dale L Phelps, Michelle Quintos, Betty Tung, Early Treatment for Retinopathy of Prematurity Cooperative Group, Velma Dobson, Graham E Quinn, C Gail Summers, Robert J Hardy, Betty Tung, William V Good, Ashima Madan, M Bethany Ball, Judith Y Hall, William V Good, William V Good, Judith Gancasz, David Durand, Terri Slagle, Gordon Smith, Michael Shapiro, Nydia Santiago, Rama Bhat, Lawrence Kaufman, Marilyn Miller, David Mittelman, Daniel Neely, Elizabeth A Hynes, David Plager, Charles C Barr, Michelle Bottorff, Greg K Whittington, Peggy H Fishman, Paul J Rychwalski, Robert A Gordon, Deborah S Neff, James G Diamond, William L Gill, Mark W Preslan, Kevin Powdrill, Kelly A Hutcheson, Eric Jones, Scott M Steidl, Joanne Marie Waeltermann, Michael X Repka, Jennifer A Shepard, Pamela Donahue, Susan W Aucott, Mary Louise Z Collins, Maureen M Gilmore, James T Handa, Deborah K VanderVeen, Theresa Mansfield, Brenda MacKinnon, Cynthia H Cole, Anthony Fraioli, David Hunter, O'Ine McCabe, Robert Petersen, Mitchell Brent Strominger, Sarah MacKinnon, Rhiannon Johnson, Mariette Tyedmers, John Baker, Kristi Cumming, Pat Manatrey, Mary P Bedard, Renato Casabar, Antonio Capone, Edward O'Malley, Rajesh Rao, John Roarty, Michael Trese, George Williams, C Gail Summers, Sally Cook, Ann Holleschau, Molly Maxwell, Stephen P Christiansen, David Brasel, Bradley V Davitt, Linda Breuer, Oscar Cruz, William Keenan, Greg Mantych, Gregg Lueder, Sharon Freedman, David Wallace, Lori Hutchins Parkman, Sarah K Jones, Laura Enyedi, Ricki F Goldstein, James D Reynolds, Kristine Ziemann, George P Albert, Steven Awner, Rita Ryan, Pamela Ann Weber, Marc Horowitz, Cherylene Behrendt, Adriann Combs, Natalie Dweck, Richard Koty, Edmund LaGamma, Maury Marmor, John Flynn, Osode Coki, Michael Chiang, Steven Kane, Alfred Krauss, Thomas C Lee, Robert F Lopez, Richard Polin, Dale L Phelps, Cassandra Horihan, Jane Phillips, Gary Markowitz, Walter Merriam, Leon-Paul Noel, Donald Tingley, Matthew Gearinger, Gary L Rogers, Don Bremer, Rae Fellows, Sharon Klamfoth, Brian Arthur, Cybil Bean Cassady, Richard Golden, Mary Lou McGregor, R Michael Siatkowski, Cheryl Harris, Vanessa Yazdanipanah, Reagan H Bradford, Robert E Leonard, Mary Anne McCaffree, David T Wheeler, Nancy Dolphin, Earl A Palmer, Ann Stout, Brian Nichols, David Epley, Graham E Quinn, Jamie G Koh, Marianne Letterio, Soraya Abbasi, Jane C Edmond, Brian J Forbes, Albert M Maguire, Monte D Mills, Eric A Pierce, Terri L Young, Stephanie Davidson, Kenneth Cheng, Janice Kelchner-Cheng, Judith Jones, Robert Bergren, Bernard Doft, Louis Lobes, Karl Olsen, Richard A Saunders, Dilip Purohit, Linda Stevens, Kimberly Lenhart, David K Coats, Michele L Parker, Maria Castanes, Alison Brown, Jane Edmond, Joseph Garcia-Prats, Eric Holz, W Scott Jarriel, Karen Johnson, George Mandy, Evelyn A Paysee, A Melinda Rainey, Paul G Steinkuller, Kimberly G Yen, John P Stokes, Yolanda Trigo, Alice K Gong, W A J van Heuven, Robert Hoffman, Susan Bracken, Deborah Y Harrison, Paul Bernstein, Jerald King, Michael Teske, Maryann Redford, Richard L Mowery, Donald F Everett, William V Good, Michelle Quintos, Robert J Hardy, Betty Tung, Gordon Tsai, Velma Dobson, Deborah D Hargadon, Jeffrey Wood, Graham E Quinn, Erin M Harvey, John Connett, Edward F Donovan, Argye Hillis, Jonathan M Holmes, Joseph M Miller, Carol R Taylor, William V Good, Robert J Hardy, Maryann Redford, William V Good, Robert J Hardy, Velma Dobson, Earl A Palmer, Dale L Phelps, Maryann Redford, W A J van Heuven, Charles Barr, Michael Gaynon, Michael Shapiro, David Wallace, Bradley V Davitt, Rae Fellows, Judith Jones, Kristi Cumming, Deborah S Neff, Jennifer A Shepard, Nancy Dolphin, V Good, Robert J Hardy, Velma Dobson, Earl A Palmer, Dale L Phelps, Michelle Quintos, Betty Tung

Abstract

Objective: To compare grating (resolution) visual acuity at 6 years of age in eyes that received early treatment (ET) for high-risk prethreshold retinopathy of prematurity (ROP) with that in eyes that underwent conventional management (CM).

Methods: In a randomized clinical trial, infants with bilateral, high-risk prethreshold ROP (n = 317) had one eye undergo ET and the other eye undergo CM, with treatment only if ROP progressed to threshold severity. For asymmetric cases (n = 84), the high-risk prethreshold eye was randomized to ET or CM.

Main outcome measure: Grating visual acuity measured at 6 years of age by masked testers using Teller acuity cards.

Results: Monocular grating acuity results were obtained from 317 of 370 surviving children (85.6%). Analysis of grating acuity results for all study participants with high-risk prethreshold ROP showed no statistically significant overall benefit of ET (18.1% vs 22.8% unfavorable outcomes; P = .08). When the 6-year grating acuity results were analyzed according to a clinical algorithm (high-risk types 1 and 2 prethreshold ROP), a benefit was seen in type 1 eyes (16.4% vs 25.2%; P = .004) undergoing ET, but not in type 2 eyes (21.3% vs 15.9%; P = .29).

Conclusion: Early treatment of eyes with type 1 ROP improves grating acuity outcomes, but ET for eyes with type 2 ROP does not. APPLICATION TO CLINICAL MEDICINE: Type 1 eyes should be treated early; however, based on acuity results at 6 years of age, type 2 eyes should be cautiously monitored for progression to type 1 ROP. Trial Registration clinicaltrials.gov Identifier: NCT00027222.

Conflict of interest statement

The authors have no affiliation with or financial interest in the subject matter or materials discussed in the paper (e.g., employment, consultancies, stock ownership, honoraria), with the exception of Velma Dobson, PhD, who has received royalties from the sale of Teller acuity cards.

Figures

Figure 1
Figure 1
Algorithm (flow chart) for randomized infants. *Incomplete data was due to failure to cooperate for monocular testing or failure to have had amblyopia therapy prescribed
Figure 2
Figure 2
Distribution of grating acuity outcomes for randomized eyes by treatment assignment. Normal = ≥ 13 cycles/degree; Below Normal =

Figure 3

Distribution of grating acuity outcomes…

Figure 3

Distribution of grating acuity outcomes for randomized eyes with Type 1(Figure 3A) and…

Figure 3
Distribution of grating acuity outcomes for randomized eyes with Type 1(Figure 3A) and Type 2 (Figure 3B) ROP by treatment assignments (early treatment (ET) or conventional management (CM)). Normal = ≥ 13 cycles/degree; Below Normal =

Figure 3

Distribution of grating acuity outcomes…

Figure 3

Distribution of grating acuity outcomes for randomized eyes with Type 1(Figure 3A) and…

Figure 3
Distribution of grating acuity outcomes for randomized eyes with Type 1(Figure 3A) and Type 2 (Figure 3B) ROP by treatment assignments (early treatment (ET) or conventional management (CM)). Normal = ≥ 13 cycles/degree; Below Normal =
Similar articles
Cited by
Publication types
MeSH terms
Associated data
Related information
[x]
Cite
Copy Download .nbib
Format: AMA APA MLA NLM

NCBI Literature Resources

MeSH PMC Bookshelf Disclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

Follow NCBI
Figure 3
Figure 3
Distribution of grating acuity outcomes for randomized eyes with Type 1(Figure 3A) and Type 2 (Figure 3B) ROP by treatment assignments (early treatment (ET) or conventional management (CM)). Normal = ≥ 13 cycles/degree; Below Normal =

Figure 3

Distribution of grating acuity outcomes…

Figure 3

Distribution of grating acuity outcomes for randomized eyes with Type 1(Figure 3A) and…

Figure 3
Distribution of grating acuity outcomes for randomized eyes with Type 1(Figure 3A) and Type 2 (Figure 3B) ROP by treatment assignments (early treatment (ET) or conventional management (CM)). Normal = ≥ 13 cycles/degree; Below Normal =
Similar articles
Cited by
Publication types
MeSH terms
Associated data
Related information
[x]
Cite
Copy Download .nbib
Format: AMA APA MLA NLM
Figure 3
Figure 3
Distribution of grating acuity outcomes for randomized eyes with Type 1(Figure 3A) and Type 2 (Figure 3B) ROP by treatment assignments (early treatment (ET) or conventional management (CM)). Normal = ≥ 13 cycles/degree; Below Normal =

Source: PubMed

赞助者和合作者

医疗条件

药物干预

3
订阅