Magnetic resonance imaging characteristics of injection site reactions after long-term subcutaneous delivery of drisapersen

Rebecca J Willcocks, Sean C Forbes, Glenn A Walter, Krista Vandenborne, Rebecca J Willcocks, Sean C Forbes, Glenn A Walter, Krista Vandenborne

No abstract available

Keywords: Antisense oligonucleotide; Dixon imaging; Lipoatrophy; Subcutaneous fat.

Figures

Fig 1. MR characteristics of lesions in subcutaneous fat.

1a. Chemical shift-based fat maps of the thigh (3 axial slices separated by ~12mm) showing areas of hypointensity (indicated with a * next to the affected area) in the subcutaneous fat adjacent to the vastus lateralis and rectus femoris muscles, which may be the result of edema, inflammation, or fibrosis 1b. Chemical shift-based water maps from the same locations as 1A, showing marked hyperintensity in the area of the lesion in subcutaneous fat (*) 1c. Over time, the inflammation or edema in the subcutaneous fat persists, while the lipoatrophy (*) progresses. Note that drisapersen administration was halted between the first and second visit, but the lesion continues to worsen over time 1d. Axial chemical shift-based water maps covering ~5.5 cm of the upper arm of a treated patient ~2.5 years after cessation of treatment, and showing the pronounced lipoatrophy (*) over the triceps brachii muscle affecting an area 5–7 cm in diameter 1e. T2 changes in the subcutaneous fat indicative of inflammation or edema can be easily seen using T2 weighted imaging (indicated with a * next to the affected area). This image was taken prior to the cessation of administration of drisapersen