COVID-19 and Multiorgan Response

Sevim Zaim, Jun Heng Chong, Vissagan Sankaranarayanan, Amer Harky, Sevim Zaim, Jun Heng Chong, Vissagan Sankaranarayanan, Amer Harky

Abstract

Since the outbreak and rapid spread of COVID-19 starting late December 2019, it has been apparent that disease prognosis has largely been influenced by multiorgan involvement. Comorbidities such as cardiovascular diseases have been the most common risk factors for severity and mortality. The hyperinflammatory response of the body, coupled with the plausible direct effects of severe acute respiratory syndrome on body-wide organs via angiotensin-converting enzyme 2, has been associated with complications of the disease. Acute respiratory distress syndrome, heart failure, renal failure, liver damage, shock, and multiorgan failure have precipitated death. Acknowledging the comorbidities and potential organ injuries throughout the course of COVID-19 is therefore crucial in the clinical management of patients. This paper aims to add onto the ever-emerging landscape of medical knowledge on COVID-19, encapsulating its multiorgan impact.

Copyright © 2020 Elsevier Inc. All rights reserved.

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Weekly cumulative data on global confirmed cases and deaths of COVID-19.

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Source: PubMed

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