Quantification of myocardial blood flow in absolute terms using (82)Rb PET imaging: the RUBY-10 Study

Sergey V Nesterov, Emmanuel Deshayes, Roberto Sciagrà, Leonardo Settimo, Jerome M Declerck, Xiao-Bo Pan, Keiichiro Yoshinaga, Chietsugu Katoh, Piotr J Slomka, Guido Germano, Chunlei Han, Ville Aalto, Adam M Alessio, Edward P Ficaro, Benjamin C Lee, Stephan G Nekolla, Kilem L Gwet, Robert A deKemp, Ran Klein, John Dickson, James A Case, Timothy Bateman, John O Prior, Juhani M Knuuti, Sergey V Nesterov, Emmanuel Deshayes, Roberto Sciagrà, Leonardo Settimo, Jerome M Declerck, Xiao-Bo Pan, Keiichiro Yoshinaga, Chietsugu Katoh, Piotr J Slomka, Guido Germano, Chunlei Han, Ville Aalto, Adam M Alessio, Edward P Ficaro, Benjamin C Lee, Stephan G Nekolla, Kilem L Gwet, Robert A deKemp, Ran Klein, John Dickson, James A Case, Timothy Bateman, John O Prior, Juhani M Knuuti

Abstract

Objectives: The purpose of this study was to compare myocardial blood flow (MBF) and myocardial flow reserve (MFR) estimates from rubidium-82 positron emission tomography ((82)Rb PET) data using 10 software packages (SPs) based on 8 tracer kinetic models.

Background: It is unknown how MBF and MFR values from existing SPs agree for (82)Rb PET.

Methods: Rest and stress (82)Rb PET scans of 48 patients with suspected or known coronary artery disease were analyzed in 10 centers. Each center used 1 of 10 SPs to analyze global and regional MBF using the different kinetic models implemented. Values were considered to agree if they simultaneously had an intraclass correlation coefficient >0.75 and a difference <20% of the median across all programs.

Results: The most common model evaluated was the Ottawa Heart Institute 1-tissue compartment model (OHI-1-TCM). MBF values from 7 of 8 SPs implementing this model agreed best. Values from 2 other models (alternative 1-TCM and Axially distributed) also agreed well, with occasional differences. The MBF results from other models (e.g., 2-TCM and retention) were less in agreement with values from OHI-1-TCM.

Conclusions: SPs using the most common kinetic model-OHI-1-TCM-provided consistent results in measuring global and regional MBF values, suggesting that they may be used interchangeably to process data acquired with a common imaging protocol.

Keywords: CAD; PET; imaging software; reproducibility; rubidium-82.

Figures

Figure 1. Cross-comparison of results from all… — **Figure 1. Cross-comparison of results from all implemented models in 10 software tools**
The X-axis for REST and STRESS is difference in MBF values (mL/min/g), for MFR in unitless ratios; Y-axis is always 1-ICC. The x-range of the shaded green area represents ± 20% of the median value

Figure 2. Cross-comparison of results from implemented… — **Figure 2. Cross-comparison of results from implemented Lortie models in eight software tools**
The X-axis for REST and STRESS is difference in MBF values (mL/min/g), for MFR in unitless ratios; Y-axis is always 1-ICC. The x-range of the shaded green area represents ± 20% of the median value.

Source: PubMed

Quantification of myocardial blood flow in absolute terms using (82)Rb PET imaging: the RUBY-10 Study

Abstract

Figures

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