Associations of visceral fat area and physical activity levels with the risk of metabolic syndrome in postmenopausal women

Izabela Zając-Gawlak, Barbara Kłapcińska, Aleksandra Kroemeke, Dariusz Pośpiech, Jana Pelclová, Miroslava Přidalová, Izabela Zając-Gawlak, Barbara Kłapcińska, Aleksandra Kroemeke, Dariusz Pośpiech, Jana Pelclová, Miroslava Přidalová

Abstract

This study was aimed at the evaluation of relationship between visceral fat area (VFA) and physical activity (PA) with the metabolic syndrome (MetS) risk in the physically active postmenopausal women. A total of 85 attendants of the University of the Third Age (U3A) aged 62.8 ± 5.9 years (median time since menopause 11.8 y), participated in this study. VFA was assessed by bioimpedance method using InBody 720 analyzer. PA was assessed using the ActiGraph GT1 M accelerometer. Fasting levels of serum lipids (TG, HDL), serum glucose, waist circumference (WC) and blood pressure were measured to diagnose MetS according to NCEP-ATP III criteria. In 73 out of 85 participants the VFA exceeded the upper normal level of 100 cm2, however, in almost a half of this group (n = 36) with elevated VFA (139.5 ± 26.1 cm2 on average), only 2 out of 5 criteria for MetS diagnosis were met. Participants were physically active, making on average 10,919 ± 3435 steps/day. The risk of MetS occurrence in women with VFA > 100 cm2 was twelve times higher (OR 12.33; CI 95% [1.5; 99.8]) than in the group with VFA < 100 cm2. The participants from the group with the highest PA level (≥12,500 steps/day) were at almost 4 times lower risk for MetS, than their less active counterparts (OR 3.84; CI 95% [1.27;11.64]). Increased level of VFA is a strong risk factor for the MetS in postmenopausal women, however high level of regular PA above the threshold of 12,500 steps/day may substantially reduce it.

Keywords: Metabolic syndrome; Physical activity; Visceral fat; Women.

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Percentages of participants (N = 85) meeting 0, 1, 2, 3, 4 or 5 criteria of the MetS. Note Median age of women stratified according to the number of MetS criteria met: 0–59.0 years; 1–60.2 years; 2–64.5 years; 3–62.0 years; 4–66.5 years and 5–61.8 years. Age-related trend p < 0.001
Fig. 2
Fig. 2
VFA levels and the number of MetS criteria met by the study participants. Note The number and median age of women stratified according to their VFA level: VFA < 100 cm2n = 12; 58.5 years; VFA = 100–150 cm2-n = 43, 62.0 years; VFA ≥ 150 cm2-n = 30, 66.0 years. Age-related trend: p < 0.001
Fig. 3
Fig. 3
Physical activity levels (PA) and the number of MetS criteria met by the study participants. Note The number and median age of women stratified according to their PA level: PA < 10,000 steps/d-n = 38, 63.0 years; PA = 10,000–12,000 steps/days-n = 24, 63.0 years; PA ≥ 12,500 steps/d-n = 32, 59.0 years. Age-related trend: p < 0.05

References

    1. Alberti KGMM, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640–1645. doi: 10.1161/CIRCULATIONAHA.109.192644.
    1. Aoyagi Y, Shephard RJ. Habitual physical activity and health in the elderly: the Nakanojo Study. Geriatr Gerontol Int. 2010;10(Suppl 1):S236–S243. doi: 10.1111/j.1447-0594.2010.00589.x.
    1. Bentley-Lewis R, Koruda K, Seely EW. The metabolic syndrome in women. Nat Clin Pract Endocrinol Metab. 2007;3:696–704. doi: 10.1038/ncpendmet0616.
    1. Biospace (2004) InBody 720—The precision body composition analyzer (User’s Manual). Seul, Korea
    1. Carr DB, Utzschneider KM, Hull RL, et al. Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes. 2004;53:2087–2094. doi: 10.2337/diabetes.53.8.2087.
    1. Cho GJ, Lee JH, Park HT, et al. Postmenopausal status according to years since menopause as an independent risk factor for the metabolic syndrome. Menopause. 2008;15:524–529. doi: 10.1097/gme.0b013e3181559860.
    1. Chodzko-Zajko WJ, Proctor DN, Fiatarone Singh MA, et al. American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc. 2009;41:1510–1530. doi: 10.1249/MSS.0b013e3181a0c95c.
    1. Choi BC, Pak AW, Choi JC, Choi EC. Daily step goal of 10,000 steps: a literature review. Clin Invest Med. 2007;30:E146–E151. doi: 10.25011/cim.v30i3.1083.
    1. Després J-P, Poirier P, Bergeron J, et al. From individual risk factors and the metabolic syndrome to global cardiometabolic risk. Eur Heart J Suppl. 2008;10:B24–B33. doi: 10.1093/eurheartj/sum041.
    1. Esliger DW, Copeland JL, Barnes JD, Tremblay MS. Standardizing and optimizing the use of accelerometer data for free-living physical activity monitoring. J Phys Act Health. 2005;2:366–383. doi: 10.1123/jpah.2.3.366.
    1. Fox CS, Massaro JM, Hoffmann U, et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation. 2007;116:39–48. doi: 10.1161/CIRCULATIONAHA.106.675355.
    1. Franklin BA, Kahn JK, Gordon NF, Bonow RO. A cardioprotective “polypill”? Independent and additive benefits of lifestyle modification. Am J Cardiol. 2004;94:162–166. doi: 10.1016/j.amjcard.2004.03.053.
    1. Frömel K, Svozil Z, Chmelík F, et al. The role of physical education lessons and recesses in school lifestyle of adolescents. J Sch Health. 2016;86:143–151. doi: 10.1111/josh.12362.
    1. Garber CE, Blissmer B, Deschenes MR, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43:1334–1359. doi: 10.1249/MSS.0b013e318213fefb.
    1. Genuth S, Alberti KGMM, Bennett P, et al. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care. 2003;26:3160–3167. doi: 10.2337/diacare.26.12.3331.
    1. Grundy SM, Brewer HB, Cleeman JI, et al. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004;109:433–438. doi: 10.1161/01.CIR.0000111245.75752.C6.
    1. Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112:2735–2752. doi: 10.1161/CIRCULATIONAHA.105.169404.
    1. Hayes L, Pearce MS, Firbank MJ, et al. Do obese but metabolically normal women differ in intra-abdominal fat and physical activity levels from those with the expected metabolic abnormalities? A cross-sectional study. BMC Public Health. 2010;10:723. doi: 10.1186/1471-2458-10-723.
    1. Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009;2:231–237. doi: 10.1242/dmm.001180.
    1. Janssen I, Powell LH, Crawford S, et al. Menopause and the metabolic syndrome: the Study of Women’s Health Across the Nation. Arch Intern Med. 2008;168:1568–1575. doi: 10.1001/archinte.168.14.1568.
    1. Kang SH, Cho KH, Park JW, Do JY. Comparison of waist to height ratio and body indices for prediction of metabolic disturbances in the Korean population: the Korean National Health and Nutrition Examination Survey 2008–2011. BMC Endocr Disord. 2015
    1. Kim HI, Kim JT, Yu SH, et al. Gender differences in diagnostic values of visceral fat area and waist circumference for predicting metabolic syndrome in Koreans. J Korean Med Sci. 2011;26:906–913. doi: 10.3346/jkms.2011.26.7.906.
    1. Kroemeke A, Zając-Gawlak I, Pośpiech D, et al. Postmenopausal obesity: 12,500 steps per day as a remedy? Relationships between body composition and daily steps in postmenopausal women. Menopause Rev. 2014;4:227–232. doi: 10.5114/pm.2014.44998.
    1. Krumm EM, Dessieux OL, Andrews P, Thompson DL. The relationship between daily steps and body composition in postmenopausal women. J Womens Health. 2006;15:202–210. doi: 10.1089/jwh.2006.15.202.
    1. Manini TM, Pahor M. Physical activity and maintaining physical function in older adults. Br J Sports Med. 2009;43:28–31. doi: 10.1136/bjsm.2008.053736.
    1. Matsuzawa Y, Funahashi T, Nakamura T. The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism. J Atheroscler Thromb. 2011;18:629–639. doi: 10.5551/jat.7922.
    1. Mosca L. Guidelines for prevention of cardiovascular disease in women: a summary of recommendations. Prev Cardiol. 2007;10(Suppl 4):19–25. doi: 10.1111/j.1520-037X.2007.07255.x.
    1. Mosca L, Banka CL, Benjamin EJ, et al. Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update. Circulation. 2007;115:1481–1501. doi: 10.1161/CIRCULATIONAHA.107.181546.
    1. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002) Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults [Adult Treatment Panel III] final report. Circulation 106:3143–3421
    1. Ogawa H, Fujitani K, Tsujinaka T, et al. InBody 720 as a new method of evaluating visceral obesity. Hepatogastroenterology. 2011;58:42–44.
    1. Park E, Kim J. Gender- and age-specific prevalence of metabolic syndrome among Korean adults: analysis of the fifth Korean National Health and Nutrition Examination Survey. J Cardiovasc Nurs. 2015;30:256–266. doi: 10.1097/JCN.0000000000000142.
    1. Park Y-W, Zhu S, Palaniappan L, et al. The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med. 2003;163:427–436. doi: 10.1001/archinte.163.4.427.
    1. Park KS, Lee D-H, Lee J, et al. Comparison between two methods of bioelectrical impedance analyses for accuracy in measuring abdominal visceral fat area. J Diabetes Complic. 2016;30:343–349. doi: 10.1016/j.jdiacomp.2015.10.014.
    1. Peppa M, Koliaki C, Dimitriadis G. Body composition as an important determinant of metabolic syndrome in postmenopausal women. Endocrinol Metab Syndr. 2013
    1. Piché M-E, Lapointe A, Weisnagel SJ, et al. Regional body fat distribution and metabolic profile in postmenopausal women. Metabolism. 2008;57:1101–1107. doi: 10.1016/j.metabol.2008.03.015.
    1. Pickhardt PJ, Jee Y, O’Connor SD, del Rio AM. Visceral adiposity and hepatic steatosis at abdominal CT: association with the metabolic synd rome. AJR Am J Roentgenol. 2012;198:1100–1107. doi: 10.2214/AJR.11.7361.
    1. Reaven GM. The insulin resistance syndrome: definition and dietary approaches to treatment. Annu Rev Nutr. 2005;25:391–406. doi: 10.1146/annurev.nutr.24.012003.132155.
    1. Rigo JC, Vieira JL, Dalacorte RR, Reichert CL. Prevalence of metabolic syndrome in an elderly community: comparison between three diagnostic methods. Arq Bras Cardiol. 2009;93:85–91. doi: 10.1590/S0066-782X2009000800004.
    1. Thompson PD, Buchner D, Pina IL, et al. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity) Circulation. 2003;107:3109–3116. doi: 10.1161/01.CIR.0000075572.40158.77.
    1. Tudor-Locke C, Bassett DR. How many steps/day are enough? Preliminary pedometer indices for public health. Sports Med Auckl NZ. 2004;34:1–8. doi: 10.2165/00007256-200434010-00001.
    1. Tudor-Locke C, Hatano Y, Pangrazi RP, Kang M. Revisiting “how many steps are enough?”. Med Sci Sports Exerc. 2008;40:S537–S543. doi: 10.1249/MSS.0b013e31817c7133.
    1. Tudor-Locke C, Craig CL, Aoyagi Y, et al. How many steps/day are enough? For older adults and special populations. Int J Behav Nutr Phys Act. 2011;8:80. doi: 10.1186/1479-5868-8-80.
    1. Tudor-Locke C, Craig CL, Brown WJ, et al. How many steps/day are enough? For adults. Int J Behav Nutr Phys Act. 2011;8:79. doi: 10.1186/1479-5868-8-79.
    1. Zając-Gawlak I, Pośpiech D, Kroemeke A, et al. Physical activity, body composition and general health status of physically active students of the University of the Third Age (U3A) Arch Gerontol Geriatr. 2016;64:66–74. doi: 10.1016/j.archger.2016.01.008.
    1. Ziaei S, Mohseni H. Correlation between Hormonal Statuses and Metabolic Syndrome in Postmenopausal Women. J Family Reprod Health. 2013;7:63–66.

Source: PubMed

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