Metabolic and hormonal response to intermittent high-intensity and continuous moderate intensity exercise in individuals with type 1 diabetes: a randomised crossover study

Lia Bally, Thomas Zueger, Tania Buehler, Ayse S Dokumaci, Christian Speck, Nicola Pasi, Carlos Ciller, Daniela Paganini, Katrin Feller, Hannah Loher, Robin Rosset, Matthias Wilhelm, Luc Tappy, Chris Boesch, Christoph Stettler, Lia Bally, Thomas Zueger, Tania Buehler, Ayse S Dokumaci, Christian Speck, Nicola Pasi, Carlos Ciller, Daniela Paganini, Katrin Feller, Hannah Loher, Robin Rosset, Matthias Wilhelm, Luc Tappy, Chris Boesch, Christoph Stettler

Abstract

Aims/hypothesis: To investigate exercise-related fuel metabolism in intermittent high-intensity (IHE) and continuous moderate intensity (CONT) exercise in individuals with type 1 diabetes mellitus.

Methods: In a prospective randomised open-label cross-over trial twelve male individuals with well-controlled type 1 diabetes underwent a 90 min iso-energetic cycling session at 50% maximal oxygen consumption ([Formula: see text]), with (IHE) or without (CONT) interspersed 10 s sprints every 10 min without insulin adaptation. Euglycaemia was maintained using oral (13)C-labelled glucose. (13)C Magnetic resonance spectroscopy (MRS) served to quantify hepatocellular and intramyocellular glycogen. Measurements of glucose kinetics (stable isotopes), hormones and metabolites complemented the investigation.

Results: Glucose and insulin levels were comparable between interventions. Exogenous glucose requirements during the last 30 min of exercise were significantly lower in IHE (p = 0.02). Hepatic glucose output did not differ significantly between interventions, but glucose disposal was significantly lower in IHE (p < 0.05). There was no significant difference in glycogen consumption. Growth hormone, catecholamine and lactate levels were significantly higher in IHE (p < 0.05).

Conclusions/interpretation: IHE in individuals with type 1 diabetes without insulin adaptation reduced exogenous glucose requirements compared with CONT. The difference was not related to increased hepatic glucose output, nor to enhanced muscle glycogen utilisation, but to decreased glucose uptake. The lower glucose disposal in IHE implies a shift towards consumption of alternative substrates. These findings indicate a high flexibility of exercise-related fuel metabolism in type 1 diabetes, and point towards a novel and potentially beneficial role of IHE in these individuals.

Trial registration: ClinicalTrials.gov NCT02068638 FUNDING: Swiss National Science Foundation (grant number 320030_149321/) and R&A Scherbarth Foundation (Switzerland).

Keywords: Carbohydrate metabolism; Exercise; Hypoglycaemia; Metabolic physiology in vivo.

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