Comparison of Whole-Body (18)F FDG PET/MR Imaging and Whole-Body (18)F FDG PET/CT in Terms of Lesion Detection and Radiation Dose in Patients with Breast Cancer

Abstract

Purpose To compare fluorine 18 ((18)F) fluorodeoxyglucose (FDG) combined positron emission tomography (PET) and magnetic resonance (MR) imaging with (18)F FDG combined PET and computed tomography (CT) in terms of organ-specific metastatic lesion detection and radiation dose in patients with breast cancer. Materials and Methods From July 2012 to October 2013, this institutional review board-approved HIPAA-compliant prospective study included 51 patients with breast cancer (50 women; mean age, 56 years; range, 32-76 years; one man; aged 70 years) who completed PET/MR imaging with diffusion-weighted and contrast material-enhanced sequences after unenhanced PET/CT. Written informed consent for study participation was obtained. Two independent readers for each modality recorded site and number of lesions. Imaging and clinical follow-up, with consensus in two cases, served as the reference standard. Results There were 242 distant metastatic lesions in 30 patients, 18 breast cancers in 17 patients, and 19 positive axillary nodes in eight patients. On a per-patient basis, PET/MR imaging with diffusion-weighted and contrast-enhanced sequences depicted distant (30 of 30 [100%] for readers 1 and 2) and axillary (eight of eight [100%] for reader 1, seven of eight [88%] for reader 2) metastatic disease at rates similar to those of unenhanced PET/CT (distant metastatic disease: 28 of 29 [96%] for readers 3 and 4, P = .50; axillary metastatic disease: seven of eight [88%] for readers 3 and 4, P > .99) and outperformed PET/CT in the detection of breast cancer (17 of 17 [100%] for readers 1 and 2 vs 11 of 17 [65%] for reader 3 and 10 of 17 [59%] for reader 4; P < .001). PET/MR imaging showed increased sensitivity for liver (40 of 40 [100%] for reader 1 and 32 of 40 [80%] for reader 2 vs 30 of 40 [75%] for reader 3 and 28 of 40 [70%] for reader 4; P < .001) and bone (105 of 107 [98%] for reader 1 and 102 of 107 [95%] for reader 2 vs 106 of 107 [99%] for reader 3 and 93 of 107 [87%] for reader 4; P = .012) metastases and revealed brain metastases in five of 51 (10%) patients. PET/CT trended toward increased sensitivity for lung metastases (20 of 23 [87%] for reader 1 and 17 of 23 [74%] for reader 2 vs 23 of 23 [100%] for reader 3 and 22 of 23 [96%] for reader 4; P = .065). Dose reduction averaged 50% (P < .001). Conclusion In patients with breast cancer, PET/MR imaging may yield better sensitivity for liver and possibly bone metastases but not for pulmonary metastases, as compared with that attained with PET/CT, at about half the radiation dose. (©) RSNA, 2016 Online supplemental material is available for this article.

Conflict of interest statement

of Conflicts of Interest: A.N.M. disclosed no relevant relationships. R.A.R. disclosed no relevant relationships. A.C.P. disclosed no relevant relationships. F.D.P. disclosed no relevant relationships. K.M.P. disclosed no relevant relationships. K.J. disclosed no relevant relationships. J.S.B. disclosed no relevant relationships. E.E.S. disclosed no relevant relationships. S.G.K. disclosed no relevant relationships. L.A.M. disclosed no relevant relationships.

Figures

Figure 1

Axial (a–c) PET/MR and (d) PET/CT images in a 64-year-old woman with a history of left breast cancer metastatic to lung and bone obtained to monitor response during chemotherapy. A liver metastasis (arrow) is seen on the PET/MR images (a–c) but not on the PET/CT image (d). The metastasis is best seen as an area of high signal intensity on the diffusion-weighted image (a), with corresponding low signal intensity on the apparent diffusion coefficient map (b). There is minimal corresponding FDG uptake on the fused diffusion-weighted and PET image (c). This metastasis was also seen on contrast-enhanced T1-weighted images (not shown). This metastasis is not seen on PET/CT images (d).

Figure 2

Axial images in a 48-year-old woman with a history of left breast cancer metastatic to lung and bone obtained to monitor response during chemotherapy. (a) Contrast-enhanced T1-weighted MR and (b) T1-weighted MR/PET images show several lung metastases (white arrow). (c) B60 kernel CT and (d) PET/CT images show these metastases (white arrow) more clearly. An expansile rib metastasis (black arrow) is seen on all images.