Effects of physical activity and sedentary behaviour on cardiometabolic risk factors and cognitive function in children: protocol for a cohort study

Yajie Lv, Li Cai, Zhaohuan Gui, Xia Zeng, Minyi Tan, Nianqing Wan, Lijuan Lai, Shaomin Lu, Weiqing Tan, Yajun Chen, Yajie Lv, Li Cai, Zhaohuan Gui, Xia Zeng, Minyi Tan, Nianqing Wan, Lijuan Lai, Shaomin Lu, Weiqing Tan, Yajun Chen

Abstract

Introduction: Although studies showed that physical activity (PA) and sedentary behaviour (SB) were associated with cardiometabolic risk factors and cognitive function, both independent and combined associations among them are inconsistent. Cardiometabolic risk factors are also associated with cognitive function, but research of children is limited. Additionally, the brain level mechanisms have not been fully established. The proposed study aims to explore the associations and mechanisms of PA and SB on cognitive function and cardiometabolic risk factors in children.

Methods and analysis: This is a school-based prospective cohort study. A total of 8324 participants of this study are primary school students aged 7-12 years old who are followed up every 2 years from January 2017 to December 2026. We used a stratified cluster random sampling to select five primary schools in Guangzhou, China. There are three phases at baseline. At phase I, we collect PA, SB and cognitive function by questionnaires and also conduct anthropometric and biochemical measurements in all participants. At phase II, PA, SB and cognitive function are measured respectively by accelerometers and cognitive tasks among participants randomly selected from four subgroups with different SB and PA levels. At phase III, event-related potentials are recorded using electroencephalogram during a cognitive task among participants randomly selected from phase II. We plan to follow-up all participants until they graduate from high school. The process applied at baseline and follow-up are approximately identical.

Ethics and dissemination: Procedures described in this manuscript have been approved by the Ethical Review Committee for Biomedical Research, School of Public Health, Sun Yat-sen University (L2016-010). All parents or guardians of participants signed the informed consent form voluntarily before participating in the study. The findings of the study will be published in peer-reviewed journals.

Trial registration number: NCT03582709.

Keywords: cardio-metabolic risk factors; children; cognitive function; physical activity; sedentary behaviour.

Conflict of interest statement

Competing interests: None declared.

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Figures

Figure 1
Figure 1
Design of the study. High SB: SB ≥ P75, low SB: SB

Figure 2

Sampling of phase II. High…

Figure 2

Sampling of phase II. High SB: SB ≥P75, low SB: SB

Figure 2
Sampling of phase II. High SB: SB ≥P75, low SB: SB
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References
    1. Pujadas Botey A, Bayrampour H, Carson V, et al. . Adherence to Canadian physical activity and sedentary behaviour guidelines among children 2 to 13 years of age. Prev Med Rep 2016;3:14–20. 10.1016/j.pmedr.2015.11.012 - DOI - PMC - PubMed
    1. World Health Organization Levels of insufficient physical activity, 2018. Available: http://www.who.int/news-room/fact-sheets/detail/physical-activity [Accessed 22 Feb 2019].
    1. Hallal PC, Andersen LB, Bull FC, et al. . Global physical activity levels: surveillance progress, pitfalls, and prospects. The Lancet 2012;380:247–57. 10.1016/S0140-6736(12)60646-1 - DOI - PubMed
    1. Andersen LB, Riddoch C, Kriemler S, et al. . Physical activity and cardiovascular risk factors in children. Br J Sports Med 2011;45:871–6. 10.1136/bjsports-2011-090333 - DOI - PubMed
    1. Ekelund U, Luan Jian'an, Sherar LB, et al. . Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents. JAMA 2012;307:704–12. 10.1001/jama.2012.156 - DOI - PMC - PubMed
Show all 38 references
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Figure 2
Figure 2
Sampling of phase II. High SB: SB ≥P75, low SB: SB

References

    1. Pujadas Botey A, Bayrampour H, Carson V, et al. . Adherence to Canadian physical activity and sedentary behaviour guidelines among children 2 to 13 years of age. Prev Med Rep 2016;3:14–20. 10.1016/j.pmedr.2015.11.012
    1. World Health Organization Levels of insufficient physical activity, 2018. Available: [Accessed 22 Feb 2019].
    1. Hallal PC, Andersen LB, Bull FC, et al. . Global physical activity levels: surveillance progress, pitfalls, and prospects. The Lancet 2012;380:247–57. 10.1016/S0140-6736(12)60646-1
    1. Andersen LB, Riddoch C, Kriemler S, et al. . Physical activity and cardiovascular risk factors in children. Br J Sports Med 2011;45:871–6. 10.1136/bjsports-2011-090333
    1. Ekelund U, Luan Jian'an, Sherar LB, et al. . Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents. JAMA 2012;307:704–12. 10.1001/jama.2012.156
    1. Saunders TJ, Chaput J-P, Tremblay MS. Sedentary behaviour as an emerging risk factor for cardiometabolic diseases in children and youth. Can J Diabetes 2014;38:53–61. 10.1016/j.jcjd.2013.08.266
    1. de Greeff JW, Bosker RJ, Oosterlaan J, et al. . Effects of physical activity on executive functions, attention and academic performance in preadolescent children: a meta-analysis. J Sci Med Sport 2018;21:501–7. 10.1016/j.jsams.2017.09.595
    1. Donnelly JE, Hillman CH, Castelli D, et al. . Physical activity, fitness, cognitive function, and academic achievement in children: a systematic review. Med Sci Sports Exerc 2016;48:1197–222. 10.1249/MSS.0000000000000901
    1. Diamond AB. The cognitive benefits of exercise in youth. Curr Sports Med Rep 2015;14:320–6. 10.1249/JSR.0000000000000169
    1. Falck RS, Davis JC, Liu-Ambrose T. What is the association between sedentary behaviour and cognitive function? A systematic review. Br J Sports Med 2017;51:800–11. 10.1136/bjsports-2015-095551
    1. Mehta R, Shortz A, Benden M. Standing up for learning: a pilot investigation on the neurocognitive benefits of Stand-Biased school Desks. Int J Environ Res Public Health 2016;13:59 10.3390/ijerph13010059
    1. Carson V, Kuzik N, Hunter S, et al. . Systematic review of sedentary behavior and cognitive development in early childhood. Prev Med 2015;78:115–22. 10.1016/j.ypmed.2015.07.016
    1. Hillman CH, Erickson KI, Kramer AF. Be smart, exercise your heart: exercise effects on brain and cognition. Nat Rev Neurosci 2008;9:58–65. 10.1038/nrn2298
    1. Liang J, Matheson BE, Kaye WH, et al. . Neurocognitive correlates of obesity and obesity-related behaviors in children and adolescents. Int J Obes 2014;38:494–506. 10.1038/ijo.2013.142
    1. Corley J, Starr JM, Deary IJ. Serum cholesterol and cognitive functions: the Lothian birth cohort 1936. Int Psychogeriatr 2015;27:439–53. 10.1017/S1041610214001197
    1. Rofey DL, Arslanian SA, El Nokali NE, et al. . Brain volume and white matter in youth with type 2 diabetes compared to obese and normal weight, non-diabetic Peers: a pilot study. Int J Dev Neurosci 2015;46:88–91. 10.1016/j.ijdevneu.2015.07.003
    1. Lande MB, Kupferman JC. Cognitive function in hypertensive children. Curr Hypertens Rep 2015;17:508 10.1007/s11906-014-0508-y
    1. Cannon JA, Moffitt P, Perez-Moreno AC, et al. . Cognitive impairment and heart failure: systematic review and meta-analysis. J Card Fail 2017;23:464–75. 10.1016/j.cardfail.2017.04.007
    1. Kerola T, Kettunen R, Nieminen T. The complex interplay of cardiovascular system and cognition: how to predict dementia in the elderly? Int J Cardiol 2011;150:123–9. 10.1016/j.ijcard.2010.10.018
    1. Kou J, Du Y, Xia L. Reliability and validity of "children strengths and difficulties questionnaire" in Shanghai norm. Shanghai Spirit Medicine 2005;01:25–8.
    1. Li Y-P, Hu X-Q, Jing Zhao, et al. . Application of the who growth reference (2007) to assess the nutritional status of children in China. Biomed Environ Sci 2009;22:130–5. 10.1016/S0895-3988(09)60035-0
    1. Freedson P, Pober D, Janz KF, et al. . Calibration of accelerometer output for children. Med Sci Sports Exerc 2005;37:S523–30. 10.1249/
    1. Léger LA, Mercier D, Gadoury C, et al. . The multistage 20 metre shuttle run test for aerobic fitness. J Sports Sci 1988;6:93–101. 10.1080/02640418808729800
    1. Zhang H. The revision of WISC-IV Chinese version. Psychological Science 2009;32:1177–9.
    1. Chaddock L, Pontifex MB, Hillman CH, et al. . A review of the relation of aerobic fitness and physical activity to brain structure and function in children. J Int Neuropsychol Soc 2011;17:975–85. 10.1017/S1355617711000567
    1. Rosburg T, Deuring G, Boillat C, et al. . Inhibition and attentional control in pedophilic child sexual offenders - An event-related potential study. Clin Neurophysiol 2018;129:1990–8. 10.1016/j.clinph.2018.06.029
    1. Wang N, He J, Wang Z, et al. . The prevalence of sufficient physical activity among primary and high school students in mainland China: a systematic review and meta-analysis. Public Health 2018;163:67–75. 10.1016/j.puhe.2018.06.019
    1. Song C, Guo H, Gong W, et al. . [Status of sedentary activities in the leisure time in Chinese pupils in 2010-2012]. Wei Sheng Yan Jiu 2017;46:705–21.
    1. Dearth-Wesley T, Howard AG, Wang H, et al. . Trends in domain-specific physical activity and sedentary behaviors among Chinese school children, 2004-2011. Int J Behav Nutr Phys Act 2017;14 10.1186/s12966-017-0598-4
    1. Wang L, Wang L. Using theory of planned behavior to predict the physical activity of children: probing gender differences. Biomed Res Int 2015;2015:1–9. 10.1155/2015/536904
    1. Sedentary Behaviour Research Network Letter to the editor: standardized use of the terms "sedentary" and "sedentary behaviours". Appl Physiol Nutr Metab 2012;37:540–2. 10.1139/h2012-024
    1. Elmesmari R, Reilly JJ, Martin A, et al. . Accelerometer measured levels of moderate-to-vigorous intensity physical activity and sedentary time in children and adolescents with chronic disease: a systematic review and meta-analysis. PLoS One 2017;12:e179429 10.1371/journal.pone.0179429
    1. Poitras VJ, Gray CE, Borghese MM, et al. . Systematic review of the relationships between objectively measured physical activity and health indicators in school-aged children and youth. Appl Physiol Nutr Metab 2016;41:S197–239. 10.1139/apnm-2015-0663
    1. Álvarez-Bueno C, Pesce C, Cavero-Redondo I, et al. . The Effect of Physical Activity Interventions on Children's Cognition and Metacognition: A Systematic Review and Meta-Analysis. J Am Acad Child Adolesc Psychiatry 2017;56:729–38. 10.1016/j.jaac.2017.06.012
    1. Aggio D, Smith L, Fisher A, et al. . Context-Specific associations of physical activity and sedentary behavior with cognition in children. Am J Epidemiol 2016;183:1075–82. 10.1093/aje/kww031
    1. Waldstein SR, Wendell CR. Neurocognitive function and cardiovascular disease. J Alzheimers Dis 2010;20:833–42. 10.3233/JAD-2010-091591
    1. Wideman L, Calkins SD, Janssen JA, et al. . Rationale, design and methods for the right track health study: pathways from childhood self-regulation to cardiovascular risk in adolescence. BMC Public Health 2016;16:459 10.1186/s12889-016-3133-7
    1. Lubans D, Richards J, Hillman C, et al. . Physical activity for cognitive and mental health in youth: a systematic review of mechanisms. Pediatrics 2016;138:e20161642 10.1542/peds.2016-1642

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