Ribosomal RNA evidence of ocular Chlamydia trachomatis infection following 3 annual mass azithromycin distributions in communities with highly prevalent trachoma
Jeremy D Keenan, Berhan Ayele, Teshome Gebre, Jeanne Moncada, Nicole E Stoller, Zhaoxia Zhou, Travis C Porco, Charles E McCulloch, Bruce D Gaynor, Paul M Emerson, Julius Schachter, Thomas M Lietman, Jeremy D Keenan, Berhan Ayele, Teshome Gebre, Jeanne Moncada, Nicole E Stoller, Zhaoxia Zhou, Travis C Porco, Charles E McCulloch, Bruce D Gaynor, Paul M Emerson, Julius Schachter, Thomas M Lietman
Abstract
Twelve trachoma-hyperendemic communities were treated with 3 annual mass azithromycin distributions. Children aged 0-9 years were monitored 1 year following the third treatment. An RNA-based test detected ocular chlamydial infection in more children than did a DNA-based test (6.9% vs 4.2%), and in a larger number of communities (8 vs 7).
Trial registration: ClinicalTrials.gov NCT00322972.
Source: PubMed