Impact of long-term contraceptive promotion on incident pregnancy: a randomized controlled trial among HIV-positive couples in Lusaka, Zambia
Kristin M Wall, Bellington Vwalika, Lisa Haddad, Naw H Khu, Cheswa Vwalika, William Kilembe, Elwyn Chomba, Rob Stephenson, David Kleinbaum, Azhar Nizam, Ilene Brill, Amanda Tichacek, Susan Allen, Kristin M Wall, Bellington Vwalika, Lisa Haddad, Naw H Khu, Cheswa Vwalika, William Kilembe, Elwyn Chomba, Rob Stephenson, David Kleinbaum, Azhar Nizam, Ilene Brill, Amanda Tichacek, Susan Allen
Abstract
Objectives: To evaluate the impact of family planning promotion on incident pregnancy in a combined effort to address Prongs 1 and 2 of prevention of mother-to-child transmission of HIV.
Design: We conducted a factorial randomized controlled trial of 2 video-based interventions.
Methods: "Methods" and "Motivational" messages promoted long-term contraceptive use among 1060 couples with HIV in Lusaka, Zambia.
Results: Among couples not using contraception before randomization (n = 782), the video interventions had no impact on incident pregnancy. Among baseline contraceptive users, viewing the "Methods video" which focused on the intrauterine device and contraceptive implant was associated with a significantly lower pregnancy incidence [hazard ratio (HR) = 0.38; 95% confidence interval (CI): 0.19 to 0.75] relative to those viewing control and/or motivational videos. The effect was strongest in concordant positive couples (HR = 0.22; 95% CI: 0.08 to 0.58) and couples with HIV-positive women (HR = 0.23; 95% CI: 0.09 to 0.55).
Conclusions: The "Methods video" intervention was previously shown to increase uptake of long-acting contraception and to prompt a shift from daily oral contraceptives to quarterly injectables and long-acting methods such as the intrauterine device and implant. Follow-up confirms sustained intervention impact on pregnancy incidence among baseline contraceptive users, in particular couples with HIV-positive women. Further work is needed to identify effective interventions to promote long-acting contraception among couples who have not yet adopted modern methods.
Trial registration: ClinicalTrials.gov NCT00067522.
Conflict of interest statement
Conflicts of interest: The authors have no conflicts of interest, including relevant financial interests, activities, relationships, and affiliations.
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Source: PubMed