Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials

Yucheng Wu, Qingqing Zhang, Yin Ren, Zhongbao Ruan, Yucheng Wu, Qingqing Zhang, Yin Ren, Zhongbao Ruan

Abstract

Objective: To assess the efficacy of probiotic Lactobacillus on serum lipids using a meta-analysis of randomized, controlled trials.

Methods: Fifteen studies containing 15 trials, with 976 subjects were included. The pooled WMD was calculated by random effects model.

Results: Probiotic Lactobacillus consumption significantly reduced TC by 0.26mmol/l (95% CI, -0.40 to -0.12) and LDL-C by 0.23mmol/l (95% CI, -0.36 to -0.10). Subgroup analysis of trials found significantly reduction of TC using L. plantarum and reduction of LDL-C using L. plantarum or L. reuteri. No significant effects were found on TG and HDL-C levels after supplementation with probiotic Lactobacillus. While, subgroup analysis found significantly beneficial effects on TG and HDL-C by consuming synbiotic food, containing L. sporogenes and inulin.

Conclusion: Consuming probiotic Lactobacillus, especially L. reuteri and L. plantarm, could reduce TC and LDL-C significantly. The study also suggested significantly beneficial effects on TG and HDL-C by consuming synbiotic food, containing L. sporogenes and inulin.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1. The study flow diagram.
Fig 1. The study flow diagram.
Fig 2. The effect of consumption of…
Fig 2. The effect of consumption of probiotic Lactobacillus on TG.
Fig 3. The effect of consumption of…
Fig 3. The effect of consumption of probiotic Lactobacillus on TC.
Fig 4. The effect of consumption of…
Fig 4. The effect of consumption of probiotic Lactobacillus on LDL.
Fig 5. The effect of consumption of…
Fig 5. The effect of consumption of probiotic Lactobacillus on HDL.
Fig 6. Begg’s funnel plot for publication…
Fig 6. Begg’s funnel plot for publication bias in trials on the effect of probiotics Lactobacillus on TG.
Fig 7. Begg’s funnel plot for publication…
Fig 7. Begg’s funnel plot for publication bias in trials on the effect of probiotics Lactobacillus on TC.
Fig 8. Begg’s funnel plot for publication…
Fig 8. Begg’s funnel plot for publication bias in trials on the effect of probiotics Lactobacillus on LDL.
Fig 9. Begg’s funnel plot for publication…
Fig 9. Begg’s funnel plot for publication bias in trials on the effect of probiotics Lactobacillus on HDL.

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