Second Wave Antibodies in Autoimmune Renal Diseases: The Case of Lupus Nephritis

Andrea Angeletti, Maurizio Bruschi, Gabriella Moroni, Renato Alberto Sinico, Franco Franceschini, Micaela Fredi, Augusto Vaglio, Lorenzo Cavagna, Andrea Petretto, Federico Pratesi, Paola Migliorini, Francesco Locatelli, Giulia Pazzola, Giampaola Pesce, Marcello Bagnasco, Angelo Manfredi, Giuseppe A Ramirez, Pasquale Esposito, Giuseppe Murdaca, Simone Negrini, Leda Cipriani, Barbara Trezzi, Giacomo Emmi, Ilaria Cavazzana, Valentina Binda, Matteo d'Alessandro, Paride Fenaroli, Isabella Pisani, Giacomo Garibotto, Carlomaurizio Montecucco, Domenico Santoro, Francesco Scolari, Stefano Volpi, Marta Mosca, Angela Tincani, Giovanni Candiano, Marco Prunotto, Enrico Verrina, Angelo Ravelli, Gian Marco Ghiggeri, Andrea Angeletti, Maurizio Bruschi, Gabriella Moroni, Renato Alberto Sinico, Franco Franceschini, Micaela Fredi, Augusto Vaglio, Lorenzo Cavagna, Andrea Petretto, Federico Pratesi, Paola Migliorini, Francesco Locatelli, Giulia Pazzola, Giampaola Pesce, Marcello Bagnasco, Angelo Manfredi, Giuseppe A Ramirez, Pasquale Esposito, Giuseppe Murdaca, Simone Negrini, Leda Cipriani, Barbara Trezzi, Giacomo Emmi, Ilaria Cavazzana, Valentina Binda, Matteo d'Alessandro, Paride Fenaroli, Isabella Pisani, Giacomo Garibotto, Carlomaurizio Montecucco, Domenico Santoro, Francesco Scolari, Stefano Volpi, Marta Mosca, Angela Tincani, Giovanni Candiano, Marco Prunotto, Enrico Verrina, Angelo Ravelli, Gian Marco Ghiggeri

Abstract

Clinical Trial registry name and registration number: Zeus study, NCT02403115.

Copyright © 2021 by the American Society of Nephrology.

Figures

Figure 1.
Figure 1.
Circulating levels of anti-SOD2 IgG2. (A) Cross-sectional study. Circulating levels of anti-SOD2 IgG2 were determined in two cohorts of patients with SLE with (459) and without (573) LN recruited at different times from the beginning of symptoms. One hundred eighty-two normal controls were studied as well. Clinical characteristics of all patients are reported in Supplemental Table 1. (B and C) Prospective study. Ninety-one LN patients recruited at the time of the diagnosis were prospectively followed for 36 months. Anti-SOD2 IgG2 (B) and anti-dsDNA IgG2 (C) levels were determined every 6 months in the first year and then every 12 months. In both cases, levels were calculated as relative intensity value (RU/ml) given the absence of WHO international standards. The line in (C) indicates normal limits for anti-dsDNA IgG2. **P<0.001 versus healthy, SLE and LN any other time point; *P<0.001 versus healthy, SLE any other time point; °P<0,001 versus T0. dsDNA, double-strain DNA.

Source: PubMed

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