Chiba study of Mother and Children's Health (C-MACH): cohort study with omics analyses

Kenichi Sakurai, Hidenobu Miyaso, Akifumi Eguchi, Yoshiharu Matsuno, Midori Yamamoto, Emiko Todaka, Hideoki Fukuoka, Akira Hata, Chisato Mori, Chiba study of Mother and Children's Health Group, Akihiro Sekine, Shinsuke Fujita, Naoki Shimojo, Masamichi Hanazato, Kaori Tachibana, Hiroko Nakaoka, Masae Otake, Norimichi Suzuki, Masahiro Watanabe, Hisao Osada, Satomi Shiga, Akiko Kawanami, Shunya Takase, Chie Koga, Hideoki Fukuoka, Kiminori Nakamura, Kazuyuki Shinohara, Masaki Kakeyama, Hirokazu Doi, Erika Sawano, Toshio Tsuji, Zu Soh, Koji Shimatani, Satoru Yamaguchi, Tsutomu Onodera, Takuhiro Yamada, Kenichi Sakurai, Hidenobu Miyaso, Akifumi Eguchi, Yoshiharu Matsuno, Midori Yamamoto, Emiko Todaka, Hideoki Fukuoka, Akira Hata, Chisato Mori, Chiba study of Mother and Children's Health Group, Akihiro Sekine, Shinsuke Fujita, Naoki Shimojo, Masamichi Hanazato, Kaori Tachibana, Hiroko Nakaoka, Masae Otake, Norimichi Suzuki, Masahiro Watanabe, Hisao Osada, Satomi Shiga, Akiko Kawanami, Shunya Takase, Chie Koga, Hideoki Fukuoka, Kiminori Nakamura, Kazuyuki Shinohara, Masaki Kakeyama, Hirokazu Doi, Erika Sawano, Toshio Tsuji, Zu Soh, Koji Shimatani, Satoru Yamaguchi, Tsutomu Onodera, Takuhiro Yamada

Abstract

Purpose: Recent epidemiological studies have shown that environmental factors during the fetal period to early childhood might affect the risk of non-communicable diseases in adulthood. This is referred to as the developmental origins of health and disease (DOHaD) concept. The Chiba study of Mother and Children's Health (C-MACH) is a birth cohort study based on the DOHaD hypothesis and involves multiomics analysis. This study aims to explore the effects of genetic and environmental factors--particularly the fetal environment and postbirth living environment--on children's health, and to identify potential biomarkers for these effects.

Participants: The C-MACH consists of three hospital-based cohorts. The study participants are pregnant women at <13 weeks gestation. Women who underwent an examination in one of the three hospitals received an explanation of the study. The participants consented to completing questionnaire surveys and the collection and storage of biological and house/environmental samples. Participants were provided unique study numbers. All of the data and biological specimens will be stored in the Chiba University Center for Preventive Medical Sciences and Chiba University Center for Preventive Medical Sciences BioBank, respectively.

Findings to date: Consent to participate was obtained from 433 women. Of these women, 376 women completed questionnaires in the early gestational period. The mean age was 32.5 (4.4) years. The mean body mass index (BMI) was 21.1 (3.0) kg/m(2). Before pregnancy, 72.3% of the women had a BMI of 18.5-24.9 kg/m(2). During early pregnancy, 5.0% of the participants smoked.

Future plans: Primary outcomes are allergy, obesity, endocrine and metabolic disorders, and developmental disorders. Genome-level, metabolome-level, umbilical cord DNA methylation (epigenome), gut microbiota and environmental chemical exposure variables will be evaluated. We will analyse the relationships between the outcomes and analytical variables.

Keywords: Birth cohort; Children; Environmental chemicals; Pregnant women.

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Figures

Figure 1
Figure 1
Follow-up programme. *Continued follow-up after the age of 5 years will be considered later.
Figure 2
Figure 2
Flow diagram of study participants.

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Source: PubMed

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