Effect of platelet-rich plasma on the rate of orthodontic tooth movement

Ahmed El-Timamy, Fouad El Sharaby, Faten Eid, Amr El Dakroury, Yehya Mostafa, Olfat Shaker, Ahmed El-Timamy, Fouad El Sharaby, Faten Eid, Amr El Dakroury, Yehya Mostafa, Olfat Shaker

Abstract

Objective: To investigate the effect of local injection of platelet-rich plasma (PRP) on the rate of orthodontic tooth movement.

Materials and methods: Sixteen female patients were randomly allocated in a split-mouth study design to receive PRP injections with CaCl2 activating solution on one side (intervention side) while the other side received CaCl2 injection only (control side). Canine retraction was performed on 0.017 × 0.025-inch stainless steel archwire applying 1.5 N retraction force. PRP and CaCl2 injections were done at 0, 3, and 6 weeks. The duration of the study was 4 months. Data were collected from digitized models. Assessment of pain accompanying the procedure was done using a visual analogue scale.

Results: The rate of canine retraction was faster on the intervention side in the first 2 months, with a statistically significant difference in the first month (P = .049). On the other hand, the rate was statistically significantly slower on the intervention side in the third month following cessation of PRP injections (P = .02). Pain increased following injections on both sides.

Conclusions: PRP showed a positive potential to accelerate the rate of tooth movement when injected in the first 2 months. Repeated injections of PRP to maintain a steady rate of accelerated tooth movement warrant further investigation.

Keywords: Acceleration; Canine retraction; Digital models; Pharmacological approaches; Platelet-rich plasma; Tooth movement.

© 2020 by The EH Angle Education and Research Foundation, Inc.

Figures

Figure 1.
Figure 1.
Fixed appliance setup during canine retraction.
Figure 2.
Figure 2.
Submucosal injection of 5 units of platelet-rich plasma at the buccal surface on the intervention side.
Figure 3.
Figure 3.
Intraligamental injection of 5 units of platelet-rich plasma in the distobuccal area of the distal surface of the canine on the intervention side.
Figure 4.
Figure 4.
Submucosal injection of 5 units of platelet-rich plasma on the palatal aspect of the intervention side.
Figure 5.
Figure 5.
Color-coded verification of the superimposition of the digital models.
Figure 6.
Figure 6.
Point localization of the canine. RCT indicates the most incisal point on the right canine tip; RMRP, mesial contact point of the maxillary right canine; LDMRP, distal contact point of the maxillary right canine; RCD1, perpendicular distance from RCT to the median palatine raphe.
Figure 7.
Figure 7.
The canine tip localized on the five consecutively superimposed digital models.
Figure 8.
Figure 8.
Measurements of canine rotation after removing images of the digital models for clarity. RMRP and RMRP f indicate the mesial contact point of the maxillary right canine at T0 and T4, respectively; LDMRP and LDMRP f, distal contact point of the maxillary right canine at T0 and T4, respectively; RMRP 1, RMRP 2, and RMRP 3, angle between the right canine and the median palatine raphe at T0; RMRP final 1, RMRP final 2, and RMRP final 3, the same angle at T4.
Figure 9.
Figure 9.
Line chart showing the rate of canine retraction on the intervention vs control sides.

Source: PubMed

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