Individual risk factors predictive of major trauma in pre-hospital injured older patients: a systematic review

Abdullah Pandor, Gordon Fuller, Munira Essat, Lisa Sabir, Chris Holt, Helen Buckley Woods, Hridesh Chatha, Abdullah Pandor, Gordon Fuller, Munira Essat, Lisa Sabir, Chris Holt, Helen Buckley Woods, Hridesh Chatha

Abstract

Background: Older adults with major trauma are frequently under-triaged, increasing the risk of preventable morbidity and mortality. The aim of this systematic review was to identify which individual risk factors and predictors are likely to increase the risk of major trauma in elderly patients presenting to emergency medical services (EMS) following injury, to inform future elderly triage tool development.

Methods: Several electronic databases (including Medline, EMBASE, CINAHL and the Cochrane Library) were searched from inception to February 2021. Prospective or retrospective diagnostic studies were eligible if they examined a prognostic factor (often termed predictor or risk factor) for, or diagnostic test to identify, major trauma. Selection of studies, data extraction and risk of bias assessments using the Quality in Prognostic Studies (QUIPS) tool were undertaken independently by at least two reviewers. Narrative synthesis was used to summarise the findings.

Results: Nine studies, all performed in US trauma networks, met review inclusion criteria. Vital signs (Glasgow Coma Scale (GCS) score, systolic blood pressure, respiratory rate and shock index with specific elderly cut-off points), EMS provider judgement, comorbidities and certain crash scene variables (other occupants injured, occupant not independently mobile and head-on collision) were identified as significant pre-hospital variables associated with major trauma in the elderly in multi-variable analyses. Heart rate and anticoagulant were not significant predictors. Included studies were at moderate or high risk of bias, with applicability concerns secondary to selected study populations.

Conclusions: Existing pre-hospital major trauma triage tools could be optimised for elderly patients by including elderly-specific physiology thresholds. Future work should focus on more relevant reference standards and further evaluation of novel elderly relevant triage tool variables and thresholds.

Keywords: emergency medical services; triage; wounds and injuries.

Conflict of interest statement

None declared.

© 2022 The Author(s).

Figures

Figure 1. Study flow chart (adapted from…
Figure 1. Study flow chart (adapted from Moher et al., 2009).
Figure 2. QUIPS assessment summary graph: review…
Figure 2. QUIPS assessment summary graph: review authors’ judgements.

References

    1. Abdou J. K., Auyeung V., Patel J. P. & Arya R. (2016). Adherence to long-term anticoagulation treatment, what is known and what the future might hold. British Journal of Haematology, 174(1), 30–42.
    1. American College of Surgeons. (2006). Resources for optimal care of the injured patient: 2006.
    1. Azami-Aghdash S., Aghaei M. H. & Sadeghi-Bazarghani H. (2018). Epidemiology of road traffic injuries among elderly people: A systematic review and meta-analysis. Bulletin of Emergency and Trauma, 6(4), 279–291.
    1. Banerjee J., Baxter M., Coats T., Edwards A., Griffiths R. & Kumar D. (2017). Major trauma in older people. The Trauma Audit & Research Network. .
    1. Benjamin E. R., Khor D., Cho J., Biswas S., Inaba K. & Demetriades D. (2018). The age of undertriage: Current trauma triage criteria underestimate the role of age and comorbidities in early mortality. Journal of Emergency Medicine, 55(2), 278–287.
    1. Boulton A. J., Peel D., Rahman U. & Cole E. (2021). Evaluation of elderly specific pre-hospital trauma triage criteria: A systematic review. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 29, 127. .
    1. Brown J. B., Gestring M. L., Forsythe R. M., Stassen N. A., Billiar T. R., Peitzman A. B. & Sperry J. L. (2015). Systolic blood pressure criteria in the National Trauma Triage Protocol for geriatric trauma: 110 is the new 90. The Journal of Trauma and Acute Care Surgery, 78(2), 352–359.
    1. Brown E., Tohira H., Bailey P. & Finn J. (2020). Is age associated with emergency medical service transport to a trauma centre in patients with major trauma? A systematic review. Australasian Journal of Paramedicine, 17. .
    1. Caterino J. M., Raubenolt A. & Cudnik M. T. (2011). Modification of Glasgow Coma Scale criteria for injured elders. Academic Emergency Medicine, 18(10), 1014–1021.
    1. Centre for Reviews and Dissemination. (2009). Systematic reviews: CRD’s guidance for undertaking reviews in health care. University of York.
    1. Coats T. & Lecky F. (2017). ‘Major trauma’: Now two separate diseases? Emergency Medicine Journal, 34(8), 494. .
    1. Cox S., Morrison C., Cameron P. & Smith K. (2014). Advancing age and trauma: Triage destination compliance and mortality in Victoria, Australia. Injury, 45(9), 1312–1319.
    1. Davidson G. H., Rivara F. P., Mack C. D., Kaufman R., Jurkovich G. J. & Bulger E. M. (2014). Validation of pre-hospital trauma triage criteria for motor vehicle collisions. The Journal of Trauma and Acute Care Surgery, 76(3), 755–761.
    1. Fuller G., Pandor A., Essat M., Sabir L., Buckley-Woods H., Chatha H., Holt C., Keating S. & Turner J. (2021). Diagnostic accuracy of pre-hospital triage tools for identifying major trauma in elderly injured patients: A systematic review. The Journal of Trauma and Acute Care Surgery, 90(2), 403–412.
    1. Gupta K., Trocio J., Keshishian A., Zhang Q., Dina O., Mardekian J., Nadkarni A. & Shank T. C. (2019). Effectiveness and safety of direct oral anticoagulants compared to warfarin in treatment naïve non-valvular atrial fibrillation patients in the US Department of defense population. BMC Cardiovascular Disorders, 19(1), 142. .
    1. Haagsma J. A., Graetz N., Bolliger I., Naghavi M., Higashi H., Mullany E. C., Abera S. F., Abraham J. P., Adofo K., Alsharif U., Ameh E. A., Ammar W., Antonio C. A. T., Barrero L. H., Bekele T., Bose D., Brazinova A., Catalß-López F., Dandona L., Vos T. (2016). The global burden of injury: Incidence, mortality, disability-adjusted life years and time trends from the Global Burden of Disease study 2013. Injury Prevention, 22(1), 3–18.
    1. Hanlon P., Nicholl B. I., Jani B. D., Lee D., McQueenie R. & Mair F. S. (2018). Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: A prospective analysis of 493,737 UK Biobank participants. Lancet Public Health, 3(7), e323–e332.
    1. Hashmi A., Ibrahim-Zada I., Rhee P., Aziz H., Fain M. J., Friese R. S. & Joseph B. (2014). Predictors of mortality in geriatric trauma patients: A systematic review and meta-analysis. Journal of Trauma and Acute Care Surgery, 76(3), 894–901.
    1. Hayden J. A., van der Windt D. A., Cartwright J. L., Côté P. & Bombardier C. (2013). Assessing bias in studies of prognostic factors. Annals of Internal Medicine, 158(4), 280–286.
    1. Kehoe A., Smith J. E., Edwards A., Yates D. & Lecky F. (2015). The changing face of major trauma in the UK. Emergency Medicine Journal, 32(12), 911–915.
    1. Kent P., Cancelliere C., Boyle E., Cassidy J. D. & Kongsted A. (2020). A conceptual framework for prognostic research. BMC Medical Research Methodology, 20, 172. .
    1. Kuhne C. A., Ruchholtz S., Kaiser G. M., Nast-Kolb D. & Working Group on Multiple Trauma of the German Society of Trauma. (2005). Mortality in severely injured elderly trauma patients – when does age become a risk factor? World Journal of Surgery, 29(11): 1476–1482.
    1. Lefebvre C., Glanville J., Briscoe S., Littlewood A., Marshall C., Metzendorf M.-I. & Wieland L. S. (2020). Searching for and selecting studies. In Higgins J. P. T., Thomas J., Chandler J., Cumpston M., Li T., Page M. J. & Welch V. A. (Eds.), Cochrane handbook for systematic reviews of interventions (Version 6.1, updated September 2020). Cochrane. .
    1. Lerner E. B., Willenbring B. D., Pirrallo R. G., Brasel K. J., Cady C. E., Colella M. R., Cooper A., Cushman J. T., Gourlay D. M., Jurkovich G. J., Newgard C. D., Salomone J. P., Sasser S. M., Shah M. N., Swor R. A. & Wang S. C. (2014). A consensus-based criterion standard for trauma center need. The Journal of Trauma and Acute Care Surgery, 76(4), 1157–1163.
    1. Linn S. (1995). The injury severity score – importance and uses. Annals of Epidemiology, 5(6), 440–446.
    1. Mackenzie E. J., Rivara F. P., Jurkovich G. J., Nathens A. B., Frey K. P., Egleston B. L., Salkever D. S., Weir S. & Scharfstein D. O. (2007). The national study on costs and outcomes of trauma. Journal of Trauma, 63(6 suppl), S54–67. .
    1. McKenzie J. E., Brennan S. E., Ryan R. E., Thomson H. J., Johnston R. V. (2019). Summarizing study characteristics and preparing for synthesis. In Higgins J. P. T., Thomas J., Chandler J., Cumpston M., Li T., Page M. J. & Welch V. A. (Eds.), Cochrane handbook for systematic reviews of interventions (Version 6.0, updated July 2019). Cochrane. .
    1. Moher D., Liberati A., Tetzlaff J., Altman D. G. & PRISMA Group. (2009). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA statement. PLoS Medicine, 6(7), e1000097. .
    1. Moran C. G., Lecky F., Bouamra O., Lawrence T., Edwards A., Woodford M., Willett K. & Coats T. J. (2018). Changing the system – major trauma patients and their outcomes in the NHS (England) 2008–17. E-Clinical Medicine, 2, 13–21. .
    1. Morissette K., Tricco A. C., Horsley T., Chen M. H. & Moher D. (2011). Blinded versus unblinded assessments of risk of bias in studies included in a systematic review. Cochrane Database of Systematic Reviews. .
    1. National Institute for Health and Care Excellence. (2016). Major trauma: Service delivery. NICE Guideline NG40. .
    1. Newgard C. D., Kampp M., Nelson M., Holmes J. F., Zive D., Rea T., Bulger E. M., Liao M., Sherck J., Hsia R. Y., Wang N. E., Fleischman R. J., Barton E. D., Daya M., Heineman J., Kuppermann N. & WESTRN Investigators. (2012). Deciphering the use and predictive value of ‘emergency medical services provider judgment’ in out-of-hospital trauma triage: A multisite, mixed methods assessment. The Journal of Trauma and Acute Care Surgery, 72(5), 1239–1248.
    1. Newgard C. D., Lin A., Eckstrom E., Caughey A., Malveau S., Griffiths D., Zive D., Bulger E. (2019). Comorbidities, anticoagulants, and geriatric-specific physiology for the field triage of injured older adults. The Journal of Trauma and Acute Care Surgery, 86(5), 829–837.
    1. Newgard C. D., Richardson D., Holmes J. F., Rea T. D., Hsia R. Y., Mann N. C., Staudenmayer K., Barton E. D., Bulger E. M., Haukoos J. S. & Western Emergency Services Translational Research Network (WESTRN) Investigators. (2014). Physiologic field triage criteria for identifying seriously injured older adults. Pre-hospital Emergency Care, 18(4), 461–470.
    1. Newgard C. D., Uribe-Leitz T. & Haider A. H. (2018). Undertriage remains a vexing problem for even the most highly developed trauma systems: The need for innovations in field triage. JAMA Surgery, 153(4), 328. .
    1. Nishijima D. K., Gaona S. D., Waechter T., Maloney R., Bair T., Blitz A., Elms A. R., Farrales R. D., Howard C., Montoya J., Bell J. M., Faul M., Vinson D. R., Garzon H., Holmes J. F., Ballard D. W. & Sacramento County Prehospital Research Consortium. (2017). Out-of-hospital triage of older adults with head injury: A retrospective study of the effect of adding ‘anticoagulation or antiplatelet medication use’ as a criterion. Annals of Emergency Medicine, 70(2), 127–138.e6.
    1. Palmer C. (2007). Major trauma and the injury severity score – where should we set the bar? Annual Proceedings/Association for the Advancement of Automotive Medicine, 51, 13–29.
    1. Riley R. D., Moons K. G. M., Snell K. I. E., Ensor J., Hooft L., Altman D. G., Hayden J., Collins G. S. & Debray T. P. A. (2019). A guide to systematic review and meta-analysis of prognostic factor studies. BMJ, 364, k4597. .
    1. Rockwood K., Song X., MacKnight C., Bergman H., Hogan D. B., McDowell I. & Mitnitski A. (2005). A global clinical measure of fitness and frailty in elderly people. Canadian Medical Association Journal, 173(5), 489–495.
    1. Sasser S. M., Hunt R. C., Faul M., Sugerman D., Pearson W. S., Dulski T., Wald M. M., Jurkovich G. J., Newgard C. D., Lerner E. B. & Centers for Disease Control and Prevention (CDC). (2012). Guidelines for field triage of injured patients: Recommendations of the National Expert Panel on Field Triage, 2011. Morbidity & Mortality Weekly Report. Recommendations & Reports, 61(RR-1), 1–20.
    1. Sasser S. M., Hunt R. C., Sullivent E. E., Wald M. M., Mitchko J., Jurkovich G. J., Henry M. C., Salomone J. P., Wang S. C., Galli R. L., Cooper A., Brown L. H., Sattin R. W. & National Expert Panel on Field Triage, Centers for Disease Control and Prevention (CDC). (2009). Guidelines for field triage of injured patients. Recommendations of the National Expert Panel on Field Triage. Morbidity & Mortality Weekly Report. Recommendations & Reports, 58(RR-1), 1–35.
    1. Scheetz L. J., Zhang J. & Kolassa J. E. (2007). Using crash scene variables to predict the need for trauma center care in older persons. Research in Nursing & Health, 30(4), 399–412.
    1. Shenkin S. D., Harrison J. K., Wilkinson T., Dodds R. M. & Ioannidis J. P. A. (2017). Systematic reviews: Guidance relevant for studies of older people. Age and Ageing, 46(5), 722–728.
    1. Thompson L., Hill M., Lecky F. & Shaw G. (2021). Defining major trauma: A Delphi study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 29(1), 63. .
    1. United Nations. (2019). World population ageing 2019: Highlights. Department of Economic and Social Affairs. .
    1. van Rein E. A. J., Houwert R. M., Gunning A. C., Lichtveld R. A., Leenen L. P. H. & van Heijl M. (2017). Accuracy of pre-hospital triage protocols in selecting severely injured patients: A systematic review. The Journal of Trauma and Acute Care Surgery, 83(2), 328–339.
    1. van Rein E. A. J., van der Sluijs R., Raaijmaakers A. M. R., Leenen L. P. H. & van Heijl M. (2018). Compliance to pre-hospital trauma triage protocols worldwide: A systematic review. Injury, 49(8), 1373–1380.
    1. van Rein E. A. J., van der Sluijs R., Voskens F. J., Lansink K. W. W., Houwert R. M., Lichtveld R. A., de Jongh M. A., Dijkgraaf M. G. W., Champion H. R., Beeres F. J. P., Leenen L. P. H. & van Heijl M. (2019). Development and validation of a prediction model for pre-hospital triage of trauma patients. JAMA Surgery, 154(5), 421–429.
    1. Vassallo J., Fuller G. & Smith J. E. (2020). Relationship between the injury severity score and the need for life-saving interventions in trauma patients in the UK. Emergency Medicine Journal, 37(8), 502–507.
    1. World Health Organization. (2005). Pre-hospital trauma care systems. .
    1. World Health Organization. (2018). Ageing and health. .

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