Herpes zoster associated hospital admissions in Italy: review of the hospital discharge forms

Giovanni Gabutti, Carlotta Serenelli, Alessandra Cavallaro, Pietro Ragni, Giovanni Gabutti, Carlotta Serenelli, Alessandra Cavallaro, Pietro Ragni

Abstract

In Italy a specific surveillance system for zoster does not exist, and thus updated and complete epidemiological data are lacking. The objective of this study was to retrospectively review the national hospital discharge forms database for the period 1999-2005 using the code ICD9-CM053. In the period 1999-2005, 35,328 hospital admissions have been registered with annual means of 4,503 hospitalizations and 543 day-hospital admissions. The great part of hospitalizations (61.9%) involved subjects older than 65 years; the mean duration of stay was 8 days. These data, even if restricted to hospitalizations registered at national level, confirm the epidemiological impact of shingles and of its complications.

Keywords: epidemiology; herpes zoster; hospital admissions.

Figures

Figure 1.
Figure 1.
Herpes zoster: hospitalizations and day-hospital admissions stratified by age classes, Italy 1999–2005.
Figure 2.
Figure 2.
Herpes zoster: hospitalizations stratified by ICD9CM code, Italy 1999–2005.

References

    1. Hambleton S, Gershon AA. Preventing Varicella-Zoster disease. Clin. Microbiol. Rev. 2005;18:70–80.
    1. Gabutti G, Rota MC, Guido M, De Donno A, Bella A, Ciofi degli Atti ML, Crovari P, Seroepidemiology Group The epidemiology of Varicella Zoster infection in Italy BMC Public Health 20088372Doi:10.1186/1471-2458-8-372.
    1. Grose C. Varicella vaccination of children in the United States: assessment after the first decade 1995–2005. J. Clin. Virol. 2005;33:89–95.
    1. Heininger U, Seward JF. Varicella. Lancet. 2006;368:1365–1376.
    1. Burke MS. Herpes Zoster vaccine: clinical trial evidence and implications for medical practice. J. Am. Osteopath. Assoc. 2007;107:S14–S18.
    1. Thomas SL, Hall AJ. What does epidemiology tell us about risk factors for herpes zoster? Lancet Infect. Dis. 2004;4:26–33.
    1. Kempf W, Meylan P, Gerber S, Aebi C, Agosti R, Buchner S, Coradi B, Garweg J, Hirsch H, Kind C, Lauper U, Lautenschlager S, Reusser P, Ruef C, Wunderli W, Nadal D. Swiss recommendations for the management of varicella zoster virus infections. Swiss Med. Wkly. 2007;137:239–251.
    1. Bowsher D. The lifetime occurrence of Herpes Zoster and prevalence of post-herpetic neuralgia: a retrospective survey in an elderly population. Eur. J. Pain. 1999;3:335–342.
    1. Bowsher D. Factors influencing the features of postherpetic neuralgia and outcome when treated with tricyclics. Eur. J. Pain. 2003;7:1–7.
    1. Jung BF, Johnson RW, Griffin DR, Dworkin RH. Risk factors for postherpetic neuralgia in patients with herpes zoster. Neurology. 2004;62:1545–1551.
    1. Whitley RJ, Gnann JW., Jr Herpes zoster in patients with human immunodeficiency virus infection – an ever-expanding spectrum of disease. Clin. Infect. Dis. 1995;21:989–990.
    1. Marocco A, Assael B, Gabutti G, Guarino A, Lopalco PL, Marchetti F, Ruggeri FM, Titone L, Tozzi AE, Vitali Rosati G, Zotti C, Franco E. Hospitalisation associated with Rotavirus gastroenteritis in Italy, 2001–2003, evaluated by means of ICD9-CM diagnostic codes. Ig. Sanità Pubbl. 2006;62:215–224.
    1. Ministro della Sanità Decreto Ministeriale 28 Dicembre 1991. Istituzione della scheda di dimissione ospedaliera. Gazzetta Ufficiale. 1992;17:13.
    1. Gabutti G, Marsella M, Lazzara C, Fiumana E, Cavallaro A, Borgna-Pignatti C. Epidemiology and burden of Rotavirus-associated hospitalizations in Ferrara, Italy. J. Prev. Med. Hyg. 2007;48:5–9.
    1. Ministero della Sanità Decreto Ministeriale 15 dicembre 1990. Sistema di sorveglianza sulle malattie infettive. Gazzetta Ufficiale. 1991;6:8–18.
    1. Di Luzio Paparatti U, Arpinelli F, Visonà G. Herpes Zoster and its complications in Italy: an observational survey. J. Infect. 1999;38:116–120.
    1. Eberti Gialloreti L, Divizia M, Pica F, Volpi A. Analysis of the cost-effectiveness of varicella vaccine programmes based on an observational survey in the Latium region in Italy. Herpes. 2005;12:33–37.
    1. Di Legami V, Gianino MM, Ciofi degli Atti M, Massari M, Migliardi A, Tomba GS, Zotti C, Zoster Study Group Epidemiology and costs of herpes zoster: background data to estimate the impact of vaccination. Vaccine. 2007;25:7598–7604.
    1. Volpi A. Varicella immunization and Herpes Zoster. Herpes. 2005;12:59.
    1. Gross G, Schofer H, Wassilew S, Friese K, Timm A, Guthoff R, Pau HW, Malin JP, Wutzler P, Doerr HW. Herpes zoster guideline of the German Dermatology Society (DDG) J. Clin. Virol. 2003;26:277–289.
    1. Dworkin R H, Schmader KE. Treatment and prevention of postherpetic neuralgia. Clin. Pract. 2003;36:877–882.
    1. Young L. Post-herpetic neuralgia: a review of advances in treatment and prevention. J. Drugs Dermatol. 2006;5:938–941.
    1. Levin ML, Smith JG, Kaufhold RM, Barber D, Hayward AR, Chan CY, Chan IS, Li DJ, Wang W, Keller PM, Shaw A, Silber JL, Schlienger K, Chalikonda I, Vessey SJ, Caulfield MJ. Decline in varicella-zoster virus (VZV)-specific cell-mediated immunity with increasing age and boosting with a high-dose VZV vaccine. JID. 2003;188:1336–1344.
    1. Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LD, Arbeit RD, Simberkoff MS, Gershon AA, Davis LE, Weinberg A, Boardman KD, Williams HM, Zhang JH, Peduzzi PN, Beisel CE, Morrison VA, Guatelli JC, Brooks PA, Kauffman CA, Pachucki CT, Neuzil KM, Betts RF, Wright PF, Griffin MR, Brunell P, Soto NE, Marques AR, Keay SK, Goodman RP, Cotton DJ, Gnann JW, jr, Loutit J, Holodniy M, Keitel WA, Crawford GE, Yeh SS, Lobo Z, Toney JF, Greenberg RN, Keller PM, Harbecke R, Hayward AR, Irwin MR, Kyriakides TC, Chan CY, Chan IS, Wang WW, Annunziato PW, Silber JL. Shingles Prevention Study Group. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. NEJM. 2005;352:2271–2284.
    1. Oxman MN. Vaccination to prevent Herpes Zoster and postherpetic neuralgia. Hum. Vacc. 2007;3:64–68.
    1. CDC Prevention of Herpes Zoster. Recommendations of the Advisory Committee on immunization practices (ACIP) MMWR. 2008;57:1–32.

Source: PubMed

3
订阅