Estimation of the dietary requirement for vitamin D in free-living adults >=64 y of age
Kevin D Cashman, Julie Mw Wallace, Geraldine Horigan, Tom R Hill, Maria S Barnes, Alice J Lucey, Maxine P Bonham, Nicola Taylor, Emeir M Duffy, Kelly Seamans, Siobhan Muldowney, Anthony P Fitzgerald, Albert Flynn, J J Strain, Mairead Kiely, Kevin D Cashman, Julie Mw Wallace, Geraldine Horigan, Tom R Hill, Maria S Barnes, Alice J Lucey, Maxine P Bonham, Nicola Taylor, Emeir M Duffy, Kelly Seamans, Siobhan Muldowney, Anthony P Fitzgerald, Albert Flynn, J J Strain, Mairead Kiely
Abstract
Background: Older adults may be more prone to developing vitamin D deficiency than younger adults. Dietary requirements for vitamin D in older adults are based on limited evidence.
Objective: The objective was to establish the dietary intake of vitamin D required to maintain serum 25-hydroxyvitamin D [25(OH)D] concentrations above various cutoffs between 25 and 80 nmol/L during wintertime, which accounted for the effect of summer sunshine exposure and diet.
Design: A randomized, placebo-controlled, double-blind, 22-wk intervention was conducted in men and women aged >/=64 y (n = 225) at supplemental levels of 0, 5, 10, and 15 microg vitamin D(3)/d from October 2007 to March 2008.
Results: Clear dose-related increments (P < 0.0001) in serum 25(OH)D were observed with increasing supplemental vitamin D(3) intakes. The slope of the relation between total vitamin D intake and serum 25(OH)D was 1.97 nmol . L(-1) . microg intake(-1). The vitamin D intake that maintained serum 25(OH)D concentrations >25 nmol/L in 97.5% of the sample was 8.6 microg/d. Intakes were 7.9 and 11.4 microg/d in those who reported a minimum of 15 min daily summer sunshine exposure or less, respectively. The intakes required to maintain serum 25(OH)D concentrations of >37.5, >50, and >80 nmol/L in 97.5% of the sample were 17.2, 24.7, and 38.7 microg/d, respectively.
Conclusion: To ensure that the vitamin D requirement is met by the vast majority (>97.5%) of adults aged >/=64 y during winter, between 7.9 and 42.8 microg vitamin D/d is required, depending on summer sun exposure and the threshold of adequacy of 25(OH)D. This trial was registered at http://www.controlled-trials.com/ISRCTN20236112 as ISRCTN registration no. ISRCTN20236112.
Source: PubMed