Clinical and Epidemiologic Characteristics and Therapeutic Management of Patients with Vibrio Infections, Bay of Biscay, France, 2001-2019

Florence Hoefler, Xavier Pouget-Abadie, Mariam Roncato-Saberan, Romain Lemarié, Eve-Marie Takoudju, François Raffi, Stéphane Corvec, Morgane Le Bras, Charles Cazanave, Philippe Lehours, Thomas Guimard, Caroline Allix-Béguec, Florence Hoefler, Xavier Pouget-Abadie, Mariam Roncato-Saberan, Romain Lemarié, Eve-Marie Takoudju, François Raffi, Stéphane Corvec, Morgane Le Bras, Charles Cazanave, Philippe Lehours, Thomas Guimard, Caroline Allix-Béguec

Abstract

Noncholera vibriosis is a rare, opportunistic bacterial infection caused by Vibrio spp. other than V. cholerae O1/O139 and diagnosed mainly during the hot summer months in patients after seaside activities. Detailed knowledge of circulating pathogenic strains and heterogeneities in infection outcomes and disease dynamics may help in patient management. We conducted a multicenter case-series study documenting Vibrio infections in 67 patients from 8 hospitals in the Bay of Biscay, France, over a 19-year period. Infections were mainly caused by V. alginolyticus (34%), V. parahaemolyticus (30%), non-O1/O139 V. cholerae (15%), and V. vulnificus (10%). Drug-susceptibility testing revealed intermediate and resistant strains to penicillins and first-generation cephalosporins. The acute infections (e.g., those involving digestive disorder, cellulitis, osteitis, pneumonia, and endocarditis) led to a life-threatening event (septic shock), amputation, or death in 36% of patients. Physicians may need to add vibriosis to their list of infections to assess in patients with associated risk factors.

Keywords: Bay of Biscay; France; Vibrio infections; amputation; antibacterial agents; antimicrobial resistance; bacteria; bacterial infections; death; diagnosis; therapeutics.

Figures

Figure
Figure
Diseases caused by Vibrio infection in 67 patients, by species, Bay of Biscay, France, 2001–2019. A) V. alginolyticus. B) V. parahaemolyticus. C) V. cholerae non-O1/O139. D) V. vulnificus. Numbers in chart sections indicate number of patients. Intraabdominal infection corresponds to pancreatitis, liver abscess, phlegmoneous ileitis, cholecystis, and peritonitis.

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Source: PubMed

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