Associations between Physiological Biomarkers and Psychosocial Measures of Pregnancy-Specific Anxiety and Depression with Support Intervention

Karen L Weis, Tony T Yuan, Katherine C Walker, Thomas F Gibbons, Wenyaw Chan, Karen L Weis, Tony T Yuan, Katherine C Walker, Thomas F Gibbons, Wenyaw Chan

Abstract

Stress and anxiety significantly impact the hypothalamic-pituitary axis, and in pregnancy, the subsequent maternal-fetal response can lead to poor outcomes. The objective of this study was to assess the association between psychosocial measures of pregnancy-specific anxiety and physiologic inflammatory responses. Specifically, to determine the effectiveness of the Mentors Offering Maternal Support (M-O-M-STM) program to reduce psychosocial anxiety and associated inflammatory response. In conjunction with measures of pregnancy-specific anxiety and depression, serum biomarkers (IL-2, IL-6, IL-10, IL1-B, TNF-α, CRH, CRP, and cortisol) were analyzed for each trimester throughout pregnancy. Results demonstrated that women receiving the M-O-M-STM intervention had longitudinally sustained lower TNF-α/IL-10 ratios than the control group, and it was significantly associated with psychosocial measures of anxiety, specifically for fears of labor and spouse/partner relationships. Additionally, the anxiety of spouse/partner relationships was significantly associated with IL-6/IL-10 ratios. The findings highlight the important counter-regulatory relationship between anti- and pro-inflammatory cytokines and provide insight into the distinct physiologic responses to pregnancy-specific anxiety with early prenatal intervention.

Keywords: cytokines; depression; intervention; military; pregnancy; prenatal anxiety.

Conflict of interest statement

The authors have no conflicts of interest to report.

Figures

Figure 1
Figure 1
(a) Longitudinal comparison of TNF-alpha/IL-10 ratio for M-O-M-STM intervention and control groups. (b) Longitudinal comparison of IL-6/IL-10 ratio for M-O-M-STM intervention and control groups. (c) Longitudinal relationship between TNF-α/IL-10 ratio to reparation for Labor anxiety for M-O-M-STM intervention and control groups. (d) Longitudinal relationship between TNF-α/IL-10 ratio to Relationship with Spouse/Partner anxiety for M-O-M-STM intervention and control groups. (e) Longitudinal relationship between IL-6/IL-10 ratio to Relationship with Spouse/Partner anxiety for M-O-M-STM intervention and control groups. (f) Longitudinal relationship between IL1β to depressive symptoms for M-O-M-STM intervention and control groups.
Figure 1
Figure 1
(a) Longitudinal comparison of TNF-alpha/IL-10 ratio for M-O-M-STM intervention and control groups. (b) Longitudinal comparison of IL-6/IL-10 ratio for M-O-M-STM intervention and control groups. (c) Longitudinal relationship between TNF-α/IL-10 ratio to reparation for Labor anxiety for M-O-M-STM intervention and control groups. (d) Longitudinal relationship between TNF-α/IL-10 ratio to Relationship with Spouse/Partner anxiety for M-O-M-STM intervention and control groups. (e) Longitudinal relationship between IL-6/IL-10 ratio to Relationship with Spouse/Partner anxiety for M-O-M-STM intervention and control groups. (f) Longitudinal relationship between IL1β to depressive symptoms for M-O-M-STM intervention and control groups.

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Source: PubMed

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