Pediatric burn resuscitation: past, present, and future

Kathleen S Romanowski, Tina L Palmieri, Kathleen S Romanowski, Tina L Palmieri

Abstract

Burn injury is a leading cause of unintentional death and injury in children, with the majority being minor (less than 10%). However, a significant number of children sustain burns greater than 15% total body surface area (TBSA), leading to the initiation of the systemic inflammatory response syndrome. These patients require IV fluid resuscitation to prevent burn shock and death. Prompt resuscitation is critical in pediatric patients due to their small circulating blood volumes. Delays in resuscitation can result in increased complications and increased mortality. The basic principles of resuscitation are the same in adults and children, with several key differences. The unique physiologic needs of children must be adequately addressed during resuscitation to optimize outcomes. In this review, we will discuss the history of fluid resuscitation, current resuscitation practices, and future directions of resuscitation for the pediatric burn population.

Conflict of interest statement

Ethics approval and consent to participate

Not applicable.

Consent for publication

All authors give consent for publication; no patient data presented.

Competing interests

The authors declare that they have no competing interests.

References

    1. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control . Web-based Injury Statistics Query and Reporting System (WISQARS) fatal injury data. 2016.
    1. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control . Web-based Injury Statistics Query and Reporting System (WISQARS) nonfatal injury data. 2016.
    1. Wolf SE, Debroy M, Herndon DN. The cornerstones and directions of pediatric burn care. Pediatr Surg Int. 1997;12:312–320. doi: 10.1007/BF01076929.
    1. Schulman CI, King DR. Pediatric fluid resuscitation after thermal injury. J Craniofac Sur. 2008;19(4):910–912. doi: 10.1097/SCS.0b013e318175b566.
    1. Barrow RE, Jeschke MG, Herndon DN. Early fluid resuscitation improves outcomes in severely burned children. Resuscitation. 2000;45:91–96. doi: 10.1016/S0300-9572(00)00175-1.
    1. Wolf SE, Rose JK, Desai MH, Mileski JP, Barrow RE, Herndon DN. Mortality determinants in massive pediatric burns. An analysis of 103 children with > or = 8% TBSA burns (> or = 70% full thickness) Ann Surg. 1997;225:554–565. doi: 10.1097/00000658-199705000-00012.
    1. Elgjo GI. Small volume hypertonic fluid treatment of burns. J Burns Surg Wound Care. 2003;2:5.
    1. von Buhl L. Epidemische cholera. Ztschr f rat Med. 1855;6:77.
    1. Underhill FP. The significance of anhydremia in extensive superficial burns. JAMA. 1930;95:852–857. doi: 10.1001/jama.1930.02720120020006.
    1. Black DA. Treatment of burn shock with plasma and serum. BMJ. 1940;2:693–697. doi: 10.1136/bmj.2.4168.693.
    1. Elman R. The therapeutic significance of plasma protein replacement in severe burns. JAMA. 1940;116:213–216. doi: 10.1001/jama.1941.02820030035008.
    1. Lam CR. Plasma therapy of burns. Ann Surg. 1941;113:1089. doi: 10.1097/00000658-194106000-00042.
    1. Cope O, Moore FD. The redistribution of body water and the fluid therapy of the burned patient. Ann Surg. 1947;126:1010–1045. doi: 10.1097/00000658-194712000-00013.
    1. Evans EI, Purnell OH, Robinett PW, Batchelor A, Martin M. Fluid and electrolyte requirements in severe burns. Ann Surg. 1952;135:804–816. doi: 10.1097/00000658-195206000-00006.
    1. Reiss E, Stirman JA, Artz CP, Davis JH, Amspacher WH. Fluid and electrolyte balance in burns. JAMA. 1953;152:1309–1313. doi: 10.1001/jama.1953.03690140017004.
    1. Baxter CR, Shires GT. Physiological response to crystalloid resuscitation of severe burns. Ann NY Acad Sci. 1968;150:874–893. doi: 10.1111/j.1749-6632.1968.tb14738.x.
    1. Fakhry SM, Alexander J, Smith D, Meyer AA, Peterson HD. Regional and institutional variation in burn care. J Burn Care Rehabil. 1995;16:86–90. doi: 10.1097/00004630-199501000-00017.
    1. Carvajal HF. Fluid resuscitation of pediatric burn victims: a critical appraisal. Pediatr Nephrol. 1994;8:357–366. doi: 10.1007/BF00866366.
    1. Lund CC. Browder NC “The estimation of areas of burns”. Surg Gynecol Obstet. 1944;79:352–358.
    1. Graves TA, Cioffi WG, McManus WF, Mason AD, Jr, Pruitt BA., Jr Fluid resuscitation of infants and children with massive thermal injury. J Trauma. 1988;28:1656–9. doi: 10.1097/00005373-198812000-00007.
    1. Merrell SW, Saffle JR, Sullivan JJ, Navar PD, Kravitz M, Warden GD. Fluid resuscitation in thermally injured children. Am J Surg. 1986;152:664–9. doi: 10.1016/0002-9610(86)90445-9.
    1. Kyle MJ, Wallace AB. Fluid replacement in burnt children. Br J Plast Surg. 1951;3:194–204. doi: 10.1016/S0007-1226(50)80030-9.
    1. Eagle JF. Parental fluid therapy of burns during the first 48 hours. NY J Med. 1956;56:1613–1618.
    1. Batchelor ADR, Kirk J, Sutherland AB. Treatment of shock in the burned child. Lancet. 1961;I:123–127. doi: 10.1016/S0140-6736(61)91307-1.
    1. Welch KJ. Thermal burns. In: Benson CD, Mustard WT, Ravitch MM, editors. Pediatric Surgery. Chicago: Year Book Medical; 1962. pp. 53–70.
    1. Chung DH. Herndon DN. In: Holcomb GW III, Murphy JP, editors. Ashcraft’s Pediatric Surgery. 5. Philadelphia: Saunders; 2009. pp. 154–166.
    1. Carvajal HF. A physiologic approach to fluid therapy in severely burned children. Surg Gynecol Obstet. 1980;150:379–384.
    1. Marinov Z, Kvalténi K, Koller J. Fluid resuscitation in thermally injured pediatric patients. Acta Chir Plast. 1997;39(1):28–32.
    1. Chung KK, Blackbourne LH, Wolf SE, White CE, Renz EM, Cancio LC, Holcomb JB, Barillo DJ. Evolution of burn resuscitation in operation Iraqi freedom. J Burn Care Res. 2006;27(5):606–611. doi: 10.1097/01.BCR.0000235466.57137.f2.
    1. Pruitt BA., Jr Protection from excessive resuscitation: “pushing the pendulum back.”. J Trauma. 2000;49:567–568. doi: 10.1097/00005373-200009000-00030.
    1. Cartotto R, Greenhalgh DG, Cancio LC. Burn state of the science: fluid resuscitation. J Burn Care Res. 2017;38(3):e596–e604.
    1. Ivy ME, Atwe NA, Palmer J, Possenti PP, Pineay M, D’Aiuto M. Intra-abdominal hypertension and abdominal compartment syndrome in burn patients. J Trauma. 1994;49:387–391. doi: 10.1097/00005373-200009000-00001.
    1. Sheridan RL, Tompkins RG, McManus WF, Pruitt BA., Jr Intracompartmental sepsis in burn patients. J Trauma. 1994;36:301–305. doi: 10.1097/00005373-199403000-00003.
    1. Zak AL, Harrington DT, Barillo DJ, Lawlor DF, Shirani KZ, Goodwin CW. Acute respiratory failure that complicates the resuscitation of pediatric patients with scald injury. J Burn Care Rehabil. 1999;20:391–399. doi: 10.1097/00004630-199909000-00011.
    1. Greenhalgh DG. Burn resuscitation: the results of the ISBI/ABA survey. Burns. 2010;36:176–182. doi: 10.1016/j.burns.2009.09.004.
    1. Kulkarni S, Harrington DT, Heffernan D, Stephen A, Connolly M, Adams C., Jr Tolerance of oliguria improves burn resuscitation. J Burn Care Res. 2013;34:S113.
    1. Dries DJ, Waxman K. Adequate resuscitation of burn patients may not be measured by urine output and vital signs. Crit Care Med. 1991;19:327–329. doi: 10.1097/00003246-199103000-00007.
    1. Saffle JR. The phenomenon of “fluid creep” in acute burn resuscitation. J Burn Care Res. 2007;28:382–395. doi: 10.1097/BCR.0B013E318053D3A1.
    1. Cancio LC, Chavez S, Alvarado-Ortega M, Barillo DJ, Walker SC, McManus AT, et al. Predicting increased fluid requirements during the resuscitation of thermally injured patients. J Trauma. 2004;56:404–13.
    1. Sheridan R, Remensnyder J, Prelack K, Petras L, Lydon M. Treatment of the seriously burned infant. J Burn Care Rehabil. 1998;19(2):115–8. doi: 10.1097/00004630-199803000-00005.
    1. Cochran A, Edelman LS, Saffle JR, Morris SE. The relationship of serum lactate and base deficit in burn patients to mortality. J Burn Care Res. 2007;28:231–240. doi: 10.1097/BCR.0B013E318031A1D1.
    1. Cancio LC, Galvez E, Jr, Turner CE, Kypreos NG, Parker A, Holcomb JB. Base deficit and alveolar-arterial gradient during resuscitation contribute independently but modestly to the prediction of mortality after burn injury. J Burn Care Res. 2006;27:289–96. doi: 10.1097/01.BCR.0000216457.25875.F4.
    1. Kamolz LP, Andel H, Schramm W, Meissl G, Herndon DN, Frey M. Lactate: early predictor of morbidity and mortality in patients with severe burns. Burns. 2005;31:986–90. doi: 10.1016/j.burns.2005.06.019.
    1. Andel D, Kamolz LE, Roka J, Schramm W, Zimpfer M, Frey M, et al. Base deficit and lactate: early predictors of morbidity and mortality in patients with burns. Burns. 2007;33:973–8. doi: 10.1016/j.burns.2007.06.016.
    1. Rivers E, Nguyen B, Havstad S. Early goal directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345(19):1368–77. doi: 10.1056/NEJMoa010307.
    1. Holm C, Mayr M, Tgeler J, Hörbrand F, Henckel von Donnersmarck G, Mühlbauer W, et al. A clinical randomized study on the effects of invasive monitoring on burn shock resuscitation. Burns. 2004;30(8):798–807.
    1. Branski LK, Herndon DN, Byrd JF, Kinsky MP, Lee JO, Fagan SP, et al. Transpulmonary thermodilution for hemodynamic measurements in severely burned children. Crit Care. 2011;15(2):R118. doi: 10.1186/cc10147.
    1. Palmieri TL. Pediatric burn resuscitation. Crit Care Clin. 2016;32(4):547–59. doi: 10.1016/j.ccc.2016.06.004.
    1. Bernard F, Gueugniaud PY, Bertin-Maghit M, Bouchard C, Vilasco B, Petit P. Prognostic significance of early cardiac index measurements in severely burned patients. Burns. 1994;20(6):529–31. doi: 10.1016/0305-4179(94)90014-0.
    1. Venet F, Plassais J, Textoris J, Cazalis MA, Pachot A, Bertin-Maghit M, et al. Low-dose hydrocortisone reduces norepinephrine duration in severe burn patients: a randomized clinical trial. Crit Care. 2015;19:21. doi: 10.1186/s13054-015-0740-0.
    1. Gajoc O, Rana R, Mendez JL, Rickman OB, Lymp JF, Hubmayr RD, et al. Acute lung injury after blood transfusion in mechanically ventilated patients. Transfusion. 2004;44:1468–74. doi: 10.1111/j.1537-2995.2004.04053.x.
    1. Pruitt BA, Jr, Mason AD, Jr, Moncrief JA. Hemodynamic changes in the early postburn patient: the influence of fluid administration and of a vasodilator (hydralazine) J Trauma. 1971;11:36–46. doi: 10.1097/00005373-197101000-00003.
    1. Carvajal HF, Parks DH. Optimal composition of burn resuscitation fluids. Crit Care Med. 1988;16:695–700. doi: 10.1097/00003246-198807000-00010.
    1. Demling RH. The burn edema process: current concepts. J Burn Care Rehabil. 2005;26:207–227. doi: 10.1097/01.BCR.0000150302.71007.80.
    1. Demling RH, Kramer GC, Gunther R, Nerlich M. Effect of nonprotein colloid on postburn edema formation in soft tissues and lung. Surgery. 1984;95:593–602.
    1. Guha SC, Kinsky MP, Button B, Herndon DN, Traber LD, Traber DL, et al. Burn resuscitation: crystalloid versus colloid versus hypertonic saline hyperoncotic colloid in sheep. Crit Care Med. 1996;24:1849–57. doi: 10.1097/00003246-199611000-00015.
    1. Vlachou E, Gosling P, Moiemen NS. Hydrixyethylstarch supplementation in burn resuscitation—a prospective randomized control trial. Burns. 2010;36:984–991. doi: 10.1016/j.burns.2010.04.001.
    1. Bechir M, Puhan MA, Neff SB. Early fluid resuscitation with hyperoncotic hydroxyethyl startch 200/0.5 (10%) in severe burn injury. Crit Care. 2010;14:R123-10.1186/cc9086. doi: 10.1186/cc9086.
    1. Cope JT, Banks D, Mauney MC, Lucktong T, Shockey KS, Kron IL, et al. Intraoperative hetastarch infusion impairs hemostasis after cardiac operations. Ann Thorac Surg. 1997;63:78–82.
    1. Lissauer ME, Kramer ME, Johnson SB, Scalea TM, Johnson SB. Association of 6% hetastarch with adverse outcomes in critically ill trauma patients. Am J Surg. 2011;202(1):53–8. doi: 10.1016/j.amjsurg.2010.05.002.
    1. Groeneveld JAB. Albumin and artificial colloids in fluid management: where does the clinical evidence of their utility stand? Crit Care. 2000;4(suppl2):S16. doi: 10.1186/cc965.
    1. Faraklas I, Lam U, Cochran A, Stoddard G, Saffle J. Colloid normalizes resuscitation ratio in pediatric burns. J Burn Care Res. 2010;32(1):91–7. doi: 10.1097/BCR.0b013e318204b379.
    1. Müller Dittrich MH, de Brunow Carvalho W, Lavado EL. Evaluation of the “early” use of albumin in children with extensive burns: a randomized controlled trial. Ped Crit Care Med. 2016;17(6):e280–286. doi: 10.1097/PCC.0000000000000728.
    1. Moyer CA, Margraf HW, Monafo WW., Jr Burn shock and extravascular sodium deficiency—treatment with Ringer’s solution with lactate. Arch Surg. 1965;90:799–811. doi: 10.1001/archsurg.1965.01320120001001.
    1. Monafo WW. The treatment of burn shock by the intravenous and oral administration of hypertonic lactated saline solution. J Trauma. 1970;10:575–586. doi: 10.1097/00005373-197007000-00006.
    1. Moylan JA, Jr, Reckler JM, Mason AD., Jr Resuscitation with hypertonic lactate saline in thermal injury. Am J Surg. 1973;125:580–584. doi: 10.1016/0002-9610(73)90141-4.
    1. Oda J, Ueyama M, Yanashita K, Inoue T, Noborio M, Ode Y, et al. Hypertonic lactated saline resuscitation reduces the risk of abdominal compartment syndrome in severely burned patients. J Trauma. 2006;60:64–71. doi: 10.1097/01.ta.0000199431.66938.99.
    1. Shimazaki S, Yoshioka T, Tanaka N, Sugimoto T, Onji Y. Body fluid changes during hypertonic lactated saline solution therapy for burn shock. J Trauma. 1977;17:38–43.
    1. Huang PP, Sticky FS, Dimick AR, Treat RC, Bessey PQ, Rue LW. Hypertonic sodium resuscitation is associated with renal failure and death. Ann Surg. 1995;221:543–54. doi: 10.1097/00000658-199505000-00012.
    1. Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M. Association between a chloride-liberal vs. chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA. 2012;308:1566–72. doi: 10.1001/jama.2012.13356.
    1. Horton JW. Free radicals and lipid peroxidation mediated injury in burn trauma: the role of antioxidant therapy. Toxicology. 2003;189:75–88. doi: 10.1016/S0300-483X(03)00154-9.
    1. Matsuda T, Tanaka H, Williams S, Hanumadass M, Abcarian H, Reyes H. Reduced fluid volume requirement for resuscitation of third degree burns with high-dose vitamin C. J Burn Care Rehabil. 1991;12:525–32. doi: 10.1097/00004630-199111000-00007.
    1. Matsuda T, Tanaka H, Shimazaki S, Matsuda H, Abcarian H, Reyes H, et al. High-dose vitamin C therapy for extensive deep dermal burns. Burns. 1992;18:127–31. doi: 10.1016/0305-4179(92)90009-J.
    1. Sakurai M, Tanaka H, Matsuda T, Goya T, Shimazaki S, Matsuda H. Reduced resuscitation fluid volume for second-degree burns with delayed initiation of vitamin C therapy (beginning 6 hours after injury) J Surg Res. 1997;73:24–7. doi: 10.1006/jsre.1997.5203.
    1. Dubick MA, Williams C, Elgjo GI, Kramer GC. High-dose vitamin C infusion reduces fluid requirements in the resuscitation of burn-injured sheep. Shock. 2005;24:139–144. doi: 10.1097/01.shk.0000170355.26060.e6.
    1. Mann R, Foster K, Kemalyan N, Gibran NS, Engrav LH, Heimbach DM. Intravenous vitamin C in clinical burn resuscitation. J Burn Care Rehabil. 1997;29:S87.
    1. Tanaka H, Matsuda T, Miyagantani Y, Yukioka T, Matsuda H, Shimazaki S. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized prospective study. Arch Surg. 2000;135:326–31. doi: 10.1001/archsurg.135.3.326.
    1. Schulman CI, Cofnas P, Manning R, Quintana O, Varas R, Pizano LR, et al. Use of high dose vitamin C in burn resuscitation. J Burn Care Res. 2011;43:S128.
    1. Lentz CW, Huelskamp S, Reid D. Adjuvant high dose ascorbic acid reduces both the volume of burn resuscitation fluids and the time to complete resuscitation in burn shock. J Burn Care Res. 2014;46:S107.
    1. Barbosa E, Faintuch J, Machado Moreira EA, da Silva VR G, Lopes Pereima MJ, Martins Fagundes RL, Filho DW. Supplementation of vitamin E, vitamin C, and zinc attenuates oxidative stress in burned children: a randomized, double-blind, placebo-controlled pilot study. J Burn Care Res. 2009;30(5):859–66. doi: 10.1097/BCR.0b013e3181b487a8.
    1. Hoskins SL, Elgjo GI, Lu J, Ying H, Grady JJ, Herndon DN, et al. Closed-loop resuscitation of burn shock. J Burn Care Res. 2006;27:377–85.
    1. Salinas J, Drew G, Gallagher J, Cancio LC, Wolf SE, Wade CE, et al. Closed-loop and decision assist resuscitation of burn patients. J Trauma. 2008;64(suppl 4):S321–32. doi: 10.1097/TA.0b013e31816bf4f7.
    1. Salinas J, Chung KK, Mann EA, Cancio LC, Kramer GC, Serio-Melvin ML, et al. Computerized decision support system improves fluid resuscitation following severe burns: an original study. Crit Care Med. 2011;39:2031–8. doi: 10.1097/CCM.0b013e31821cb790.

Source: PubMed

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