Hesperidin: A Therapeutic Agent For Obesity

Haijun Xiong, Jin Wang, Qian Ran, Guanhua Lou, Chengyi Peng, Qingxia Gan, Ju Hu, Jilin Sun, Renchuan Yao, Qinwan Huang, Haijun Xiong, Jin Wang, Qian Ran, Guanhua Lou, Chengyi Peng, Qingxia Gan, Ju Hu, Jilin Sun, Renchuan Yao, Qinwan Huang

Abstract

Obesity is a chronic metabolic disease caused by multiple factors and is considered to be a risk factor for type 2 diabetes, cardiovascular disease, hypertension, stroke and various cancers. Hesperidin, a flavanone glycoside, is a natural phenolic compound with a wide range of biological effects. Mounting evidence has demonstrated that hesperidin possesses inhibitory effect against obesity diseases. Our review discusses mechanisms of hesperidin in the treatment of obesity. Hesperidin regulates lipid metabolism and glucose metabolism by mediating AMPK and PPAR signaling pathways, directly regulates antioxidant index and anti-apoptosis, and indirectly mediates NF-κB signaling pathway to regulate inflammation to play a role in the treatment of obesity. In addition, hesperidin-enriched dietary supplements can significantly improve symptoms such as postprandial hyperglycemia and hyperlipidemia. Further clinical trials are also required for confirming lipid-lowering efficacy of this natural flavonoid and evaluating its safety profile.

Keywords: anti-inflammatory; anti-oxidation; citrus flavonoids; glucose metabolism; lipid metabolism.

Conflict of interest statement

Jilin Sun is the general manager of Sichuan Fuzheng Pharmaceutical Co. Ltd. The authors report no other conflicts of interest in this work.

© 2019 Xiong et al.

Figures

Figure 1
Figure 1
Chemical structures of hesperidin (A) and hesperetin (B).
Figure 2
Figure 2
The effect of hesperidin on lipid metabolism. Note:indicate inhibition/reduction while indicate increase/promotion.
Figure 3
Figure 3
The effect of hesperidin on glucose metabolism. Note:indicate inhibition/reduction while indicate increase/promotion.
Figure 4
Figure 4
The effect of hesperidin on oxidation and inflammation. Note:indicate inhibition/reduction while indicate increase/promotion.

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