Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention: JACC Health Promotion Series

Peter E H Schwarz, Patrick Timpel, Lorenz Harst, Colin J Greaves, Mohammed K Ali, Jeffrey Lambert, Mary Beth Weber, Mohamad M Almedawar, Henning Morawietz, Peter E H Schwarz, Patrick Timpel, Lorenz Harst, Colin J Greaves, Mohammed K Ali, Jeffrey Lambert, Mary Beth Weber, Mohamad M Almedawar, Henning Morawietz

Abstract

The primary objective of this study was to analyze the most up-to-date evidence regarding whether and how blood sugar regulation influences cardiovascular health promotion and disease prevention by carrying out an umbrella review. Three separate, systematic literature searches identified 2,343 papers in total. Overall, 44 studies were included for data extraction and analysis. The included systematic reviews and meta-analyses published between January 1, 2016, and December 31, 2017, were of good to very good quality (median Overview Quality Assessment Questionnaire score = 17). Identified evidence suggests that cardiovascular disease (CVD) prevention services should consider regulation of blood glucose as a key target for intervention. Furthermore, the recommendations for effective intervention and service development/training described here for prevention of CVD should be adopted into evidence-based practice guidelines. Multidisciplinary teams should be formed to deliver multicomponent interventions in community-based settings. There may be substantial opportunities for integrating CVD and diabetes prevention services.

Keywords: blood glucose; diabetes mellitus; diet; exercise; health behavior; umbrella review; weight loss.

Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Figures

FIGURE 1:. PRISMA Flow Chart of study…
FIGURE 1:. PRISMA Flow Chart of study selection process
PRISMA Flow Chart shows the study selection process covering the single steps of identification via two-step-screening (title and abstract as well as full text base) for eligibility and inclusion into qualitative synthesis of this review.
FIGURE 2:. Blood Sugar Regulation: Logic Order…
FIGURE 2:. Blood Sugar Regulation: Logic Order and Interdependencies
Cardiovascular disease (CVD) risk is influenced by blood glucose regulation, and both CVD risk and blood glucose regulation are influenced by interventions targeting pathophysiological mechanisms (1a, 1b). Other risk factors also affect CVD risk. Blood glucose regulation and other risk factors are, in turn, influenced by changes in behavioral risk factors. Population-level (3a, 3b) and individual-level (2a, 2b) interventions and intervention components influence the behavioral risk factors, influencing blood glucose regulation and, ultimately, CVD risk. Boxes represent the objectives of the individual review sections; arrows show the interdependencies of the objectives for their contribution to the explanation of CVD risk.

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Source: PubMed

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