Genome-wide association study identifies two susceptibility loci for osteosarcoma
Sharon A Savage, Lisa Mirabello, Zhaoming Wang, Julie M Gastier-Foster, Richard Gorlick, Chand Khanna, Adrienne M Flanagan, Roberto Tirabosco, Irene L Andrulis, Jay S Wunder, Nalan Gokgoz, Ana Patiño-Garcia, Luis Sierrasesúmaga, Fernando Lecanda, Nilgün Kurucu, Inci Ergurhan Ilhan, Neriman Sari, Massimo Serra, Claudia Hattinger, Piero Picci, Logan G Spector, Donald A Barkauskas, Neyssa Marina, Silvia Regina Caminada de Toledo, Antonio S Petrilli, Maria Fernanda Amary, Dina Halai, David M Thomas, Chester Douglass, Paul S Meltzer, Kevin Jacobs, Charles C Chung, Sonja I Berndt, Mark P Purdue, Neil E Caporaso, Margaret Tucker, Nathaniel Rothman, Maria Teresa Landi, Debra T Silverman, Peter Kraft, David J Hunter, Nuria Malats, Manolis Kogevinas, Sholom Wacholder, Rebecca Troisi, Lee Helman, Joseph F Fraumeni Jr, Meredith Yeager, Robert N Hoover, Stephen J Chanock, Sharon A Savage, Lisa Mirabello, Zhaoming Wang, Julie M Gastier-Foster, Richard Gorlick, Chand Khanna, Adrienne M Flanagan, Roberto Tirabosco, Irene L Andrulis, Jay S Wunder, Nalan Gokgoz, Ana Patiño-Garcia, Luis Sierrasesúmaga, Fernando Lecanda, Nilgün Kurucu, Inci Ergurhan Ilhan, Neriman Sari, Massimo Serra, Claudia Hattinger, Piero Picci, Logan G Spector, Donald A Barkauskas, Neyssa Marina, Silvia Regina Caminada de Toledo, Antonio S Petrilli, Maria Fernanda Amary, Dina Halai, David M Thomas, Chester Douglass, Paul S Meltzer, Kevin Jacobs, Charles C Chung, Sonja I Berndt, Mark P Purdue, Neil E Caporaso, Margaret Tucker, Nathaniel Rothman, Maria Teresa Landi, Debra T Silverman, Peter Kraft, David J Hunter, Nuria Malats, Manolis Kogevinas, Sholom Wacholder, Rebecca Troisi, Lee Helman, Joseph F Fraumeni Jr, Meredith Yeager, Robert N Hoover, Stephen J Chanock
Abstract
Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. To better understand the genetic etiology of osteosarcoma, we performed a multistage genome-wide association study consisting of 941 individuals with osteosarcoma (cases) and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: a locus in the GRM4 gene at 6p21.3 (encoding glutamate receptor metabotropic 4; rs1906953; P = 8.1 × 10⁻⁹) and a locus in the gene desert at 2p25.2 (rs7591996 and rs10208273; P = 1.0 × 10⁻⁸ and 2.9 × 10⁻⁷, respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma.
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Source: PubMed